39180-81-9 Usage
General Description
[(2,4-dichlorophenyl)methyl](propyl)amine, also known as dichlorophenylpropylamine, is a chemical compound with the molecular formula C11H14Cl2N. It is a member of the amphetamine class of stimulant drugs and is an analog of the more commonly known amphetamine. [(2,4-dichlorophenyl)methyl](propyl)amine acts as a norepinephrine-dopamine releasing agent (NDRA) and has been found to exhibit central nervous system stimulant effects. It may be used for research purposes, but its potential for abuse and addiction makes it a controlled substance in many countries. Additionally, dichlorophenylpropylamine has been studied for its potential therapeutic applications in the treatment of various medical conditions, including attention deficit hyperactivity disorder (ADHD) and obesity.
Check Digit Verification of cas no
The CAS Registry Mumber 39180-81-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,9,1,8 and 0 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 39180-81:
(7*3)+(6*9)+(5*1)+(4*8)+(3*0)+(2*8)+(1*1)=129
129 % 10 = 9
So 39180-81-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H13Cl2N/c1-2-5-13-7-8-3-4-9(11)6-10(8)12/h3-4,6,13H,2,5,7H2,1H3
39180-81-9Relevant articles and documents
Tertiary Amine Pyrazolones and Their Salts as Inhibitors of Mutant Superoxide Dismutase 1-Dependent Protein Aggregation for the Treatment of Amyotrophic Lateral Sclerosis
Zhang, Yinan,Zhao, Kevin Tianmeng,Fox, Susan G.,Kim, Jinho,Kirsch, Donald R.,Ferrante, Robert J.,Morimoto, Richard I.,Silverman, Richard B.
, p. 5942 - 5949 (2015/08/24)
Pyrazolone derivatives have previously been found to be inhibitors of Cu/Zn superoxide dismutase 1 (SOD1)-dependent protein aggregation, which extended survival of an amyotrophic lateral sclerosis (ALS) mouse model. On the basis of ADME analysis, we describe herein a new series of tertiary amine-containing pyrazolones and their structure-activity relationships. Further conversion to the conjugate salts greatly improved their solubility. Phosphate compound 17 exhibited numerous benefits both to cellular activity and to CNS-related drug-like properties in vitro and in vivo, including microsomal stability, tolerated toxicity, and blood-brain barrier permeation. These results indicate that tertiary amine pyrazolones comprise a valuable class of ALS drug candidates.
