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39186-58-8

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39186-58-8 Usage

Chemical Properties

white to light yellow crystalline powder

Uses

4-BROMO-2,2-DIPHENYLBUTYRONITRILE is a reagent used in the prepration of neurological antagonists.

Flammability and Explosibility

Notclassified

Check Digit Verification of cas no

The CAS Registry Mumber 39186-58-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,9,1,8 and 6 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 39186-58:
(7*3)+(6*9)+(5*1)+(4*8)+(3*6)+(2*5)+(1*8)=148
148 % 10 = 8
So 39186-58-8 is a valid CAS Registry Number.
InChI:InChI=1/C16H14BrN/c17-12-11-16(13-18,14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-10H,11-12H2

39186-58-8 Well-known Company Product Price

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  • Alfa Aesar

  • (A17786)  4-Bromo-2,2-diphenylbutyronitrile, 95%   

  • 39186-58-8

  • 25g

  • 420.0CNY

  • Detail
  • Alfa Aesar

  • (A17786)  4-Bromo-2,2-diphenylbutyronitrile, 95%   

  • 39186-58-8

  • 100g

  • 1421.0CNY

  • Detail
  • Alfa Aesar

  • (A17786)  4-Bromo-2,2-diphenylbutyronitrile, 95%   

  • 39186-58-8

  • 500g

  • 6344.0CNY

  • Detail

39186-58-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-BROMO-2,2-DIPHENYLBUTYRONITRILE

1.2 Other means of identification

Product number -
Other names 4-bromo-2,2-diphenylbutanenitrile

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:39186-58-8 SDS

39186-58-8Relevant articles and documents

Synthesis and structure-activity relationships of A novel class of dithiocarbamic acid esters as anticancer agent

Hou, Xueling,Ge, Zemei,Wang, Tingmin,Guo, Wei,Wu, Jun,Cui, Jingrong,Lai, Chingsan,Li, Runtao

scheme or table, p. 320 - 332 (2011/11/05)

Based on a novel lead compound 4-methylpiperazine-1-carbodithioic acid 3-cyano-3,3-diphenylpropyl ester 1, the systematic structural modification was carried out. All the synthesized compounds were evaluated for their in-vitro anticancer activities on four to six different cell lines at three different concentrations. Most of the tested compounds could selectively inhibit the growth of HL-60 and Bel-7402 cell lines at a medium concentration. Four compounds (3f, 3g, 3n, and 5) were selected for the IC50 test, and the results revealed that three compounds (3g, 3n, and 5) showed almost the same or a slightly weaker activity than compound 1 against HL-60, and three compounds (3f, 3g, and 3n) showed >2-fold higher potency than compound 1 against Bel-7402. The in-vivo efficacy of 3n · HCl was evaluated with transplanted hepatocyte carcinoma 22 as an in-vivo test model. It was found that 3n · HCl could inhibit significantly the growth of tumor, and that this effect was dose-dependent. Meanwhile, the compound 3n · HCl showed low toxicity compared with compound 1 · HCl as evidenced by the little body-weight loss. These results confirmed that compound 3n · HCl is more potent than the lead compound 1 · HCl. Preliminary structure-activity relationships indicated that: a) Both nitrile group and the cyclic amine containing at least two nitrogens were indispensable moieties to keep the activity; b) substitution of the piperazine ring is unfavorable for the improvement of activity; c) the suitable linker joining the piperazinyl dithiocarboxyl and diphenylacetonitril group should be ethylene; d) a non-coplanar arrangement of the two benzene rings appears to be essential for activity. Based on a novel lead compound 4-methyl-piperazine-1-carbodithioic acid 3-cyano-3,3-diphenyl-propyl ester 1, the systematic structural modification was carried out. Compounds 3g and 3n were found to show more potent biological activities than lead compound 1. Some useful SARs were revealed Copyright

Muscarinic receptor antagonists

-

, (2008/06/13)

Compounds of the formula I STR1 wherein X, Y and v are as defined below, novel intermediates used in their synthesis, and the pharmaceutically acceptable salts of such compounds and intermediates. The compounds of formula I and the novel intermediates used in their synthesis are muscarinic receptor antagonists that are selected for smooth muscle muscarinic sites and are useful in the prevention and treatment of diseases associated with altered motility or tone of smooth muscle, such as irritable bowel syndrome, diverticular disease, urinary incontinence, aesophageal achalasia, and chronic obstructive airways disease.

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