391906-07-3Relevant articles and documents
SALT OF A PYRIDYL ETHANOLAMINE DERIVATIVE AND ITS USE AS A BETA-3-ADRENERGIC RECEPTOR AGONIST
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Page/Page column 19-20, (2008/06/13)
The present invention provides the tosylate salt of (R)-2-(2-(4-oxazol-4-yl-phenoxy)-ethylamino)-1-pyridin-3-yl-ethanol, the monohydrate of such salt, processes useful in the preparation of such salt and such monohydrate, pharmaceutical compositions compr
2,4-Thiazolidinediones as potent and selective human β3 agonists
Hu, Baihua,Ellingboe, John,Gunawan, Iwan,Han, Stella,Largis, Elwood,Li, Zenan,Malamas, Michael,Mulvey, Ruth,Oliphant, Alexander,Sum, Fuk-Wah,Tillett, Jeff,Wong, Victoria
, p. 757 - 760 (2007/10/03)
Methylsulfonamide substituted 2,4-thiazolidinedione 22c is a potent (EC50 = 0.01 μM, IA = 1.19) and selective (more than 110-fold over β1 and β2 agonist activity) β3 agonist. This compound has also been proven to be active and selective in an in vivo mode.