392692-71-6Relevant articles and documents
Stereocontrolled total synthesis of (+)-altohyrtin A/spongistatin 1
Paterson, Ian,Chen, David Y.-K.,Coster, Mark J.,Acea, Jose L.,Bach, Jordi,Gibson, Karl R.,Keown, Linda E.,Oballa, Renata M.,Trieselmann, Thomas,Wallace, Debra J.
, p. 4055 - 4060 (2001)
As an exceptionally potent antimitotic macrolide, altohyrtin A/spongistatin 1 shows great promise in cancer chemotherapy but its extreme scarcity in the natural sponges has halted its further preclinical development. A highly stereocontrolled total synthe