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393-36-2

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393-36-2 Usage

Chemical Properties

White to off-white crystalline

Uses

4-Bromo-3-(trifluoromethyl)aniline has been used in the preparation of:2,5-dibromo-(trifluoromethyl)benzene and 2-bromo-5-iodo-(trifluoromethyl)benzeneAUY954, an aminocarboxylate analog of FTY720, a low nanomolar, monoselective agonist of the sphingosine-1-phosphate receptor

Check Digit Verification of cas no

The CAS Registry Mumber 393-36-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,9 and 3 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 393-36:
(5*3)+(4*9)+(3*3)+(2*3)+(1*6)=72
72 % 10 = 2
So 393-36-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H5BrF3N/c8-6-2-1-4(12)3-5(6)7(9,10)11/h1-3H,12H2

393-36-2 Well-known Company Product Price

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  • Alfa Aesar

  • (A18380)  4-Bromo-3-(trifluoromethyl)aniline, 98%   

  • 393-36-2

  • 1g

  • 208.0CNY

  • Detail
  • Alfa Aesar

  • (A18380)  4-Bromo-3-(trifluoromethyl)aniline, 98%   

  • 393-36-2

  • 5g

  • 337.0CNY

  • Detail
  • Alfa Aesar

  • (A18380)  4-Bromo-3-(trifluoromethyl)aniline, 98%   

  • 393-36-2

  • 25g

  • 1103.0CNY

  • Detail

393-36-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Bromo-3-(trifluoromethyl)aniline

1.2 Other means of identification

Product number -
Other names 5-Amino-2-bromobenzotrifluoride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:393-36-2 SDS

393-36-2Relevant articles and documents

Cu-mediated selective bromination of aniline derivatives and preliminary mechanism study

Zhao, Hong-Yi,Yang, Xue-Yan,Lei, Hao,Xin, Minhang,Zhang, San-Qi

supporting information, p. 1406 - 1415 (2019/05/01)

A simple and efficient bromination of aniline, aniline derivatives, and analogs have been developed. Forty three examples were given and the highest yield reached was 98%. Different substrates including substituted aniline, pyridin-amine, N-substituted aniline, N,N-disubstituted aniline, N-phenyl-amide, N-phenyl-sulfonamide, and nitrogen-containing heterocycles were all reactive and selectively generated desired bromo-products. The method can be applied to synthesize drug intermediate and quinoxaline derivatives.

2-bromo-5- fluorine three fluorine methylbenzene preparation method

-

Paragraph 0106-0107, (2017/04/03)

The invention discloses a method for preparing 2-bromine-5-trifluorotoluene chloride. The method comprises the following step: under an anhydrous condition and in an organic solvent, performing cracking reaction on an anhydrous compound 1 or a compound 1', thereby preparing 2-bromine-5-trifluorotoluene chloride. According to the method, the reaction of an upper amino protecting group of m-trifluoromethyl phenylamine, the bromination reaction and the reaction of removing the amino protecting group can be all performed in one same reaction kettle without transferring or storing materials. The raw materials used in the method disclosed by the invention are cheap and easy to obtain, the reaction step is short, the reaction condition is gentle, the utilization rate of bromine is high, and the positioning selectivity of bromine feeding is high, so that a final product is low in isomeride impurity, high in reaction conversion rate, high in yield, high in product purity, low in production cost is low and applicable to industrialization production. The compound 1 and compound 1' are as shown in the specification.

Design and development of oxobenzimidazoles as novel androgen receptor antagonists

Elancheran,Saravanan,Choudhury, Bhaswati,Divakar,Kabilan,Ramanathan,Das, Babulal,Devi,Kotoky, Jibon

, p. 539 - 552 (2016/03/08)

Antiandrogens are a novel class of anticancer agents that inhibit cancer cell proliferation and induce apoptosis in various cell lines. To find the lead compound from the oxobenzimidazole derivatives, receptor-ligand docking studies were initially performed using Schr?dinger software. The best fit molecules were synthesized and characterized through IR, 1H-NMR, 13C-NMR and HRMS analyses. The structure of compound (9b) was further confirmed by single-crystal XRD analysis. The cell viability of the compounds was determined by MTT assay to find IC50 values against prostate cancer and breast cancer cell lines (PC-3, LNCaP, MCF-7 and MDA-MB-231). The ADME/T property studies were performed to rationalize the inhibitory properties of these compounds. It can be concluded from the study that 9b is the most active compound from the series against PC-3 and LNCaP cell lines.

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