393-56-6

Basic information

• Product Name: N,N-DIMETHYL-2-FLUOROANILINE
• Synonyms: 1-(DIMETHYLAMINO)-2-FLUOROBENZENE;N,N-DIMETHYL-2-FLUOROANILINE;2-fluoro-N,N-DiMethylaniline;N-(2-Fluorophenyl)dimethylamine
• CAS NO: 393-56-6
• Molecular Formula: C₈H₁₀FN
• Molecular Weight: 139.17
• Mol File: 393-56-6.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 66-67 °C(Press: 13 Torr)
• Appearance: /
• Density: 1.057±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.93±0.18(Predicted)
• CAS DataBase Reference: N,N-DIMETHYL-2-FLUOROANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-DIMETHYL-2-FLUOROANILINE(393-56-6)
• EPA Substance Registry System: N,N-DIMETHYL-2-FLUOROANILINE(393-56-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 393-56-6(Hazardous Substances Data)

Usage

General Description

N,N-Dimethyl-2-fluoroaniline is a chemical compound with the molecular formula C8H10FN. It is a substituted aniline, which is a type of aromatic amine. N,N-DIMETHYL-2-FLUOROANILINE is used in various industrial applications, including as an intermediate in the synthesis of pharmaceuticals, dyes, and other organic compounds. It is also used as a reagent in organic synthesis to introduce the fluorine atom into the structure of organic molecules. N,N-Dimethyl-2-fluoroaniline is considered to be a hazardous chemical and proper precautions should be taken when handling it, as it may be harmful if swallowed, inhaled, or absorbed through the skin.

Upstream product

• 67-56-1 methanol 
• 348-54-9 2-Fluoroaniline 
• 50-00-0 formaldehyd 
• 1978-38-7 2-fluoro-N-methylaniline 
• 124-38-9 carbon dioxide 
• 698-00-0 2-bromo-N,N-dimethylaniline 
• 77-78-1 dimethyl sulfate 
• 363-85-9 2-fluoro-tri-N-methyl-anilinium; iodide 
• 121-69-7 N,N-dimethyl-aniline 

Downstream Products

• 321-25-5 2-fluoro-N,N-dimethyl-4-phenylazo-aniline 
• 824-48-6 N-(2-fluorophenyl)formamide 
• 1408088-31-2 2-fluoro-N,N-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 
• 321-25-5 trans-3-Fluor-4-dimethylamino-azobenzol 
• 3824-31-5 2-fluoro-N₁,N₁-dimethylbenzene-1,4-diamine 
• 445-17-0 2-fluoro-4-hydroxymethyl-tri-N-methyl-anilinium; iodide 
• 139778-28-2 o-(Dimethylamino)phenyl hydrogen sulfate 
• 1426-46-6 trans-4'-Nitro-3-fluor-4-dimethylamino-azobenzol 
• 673-13-2 trans-2',5'-Dichlor-3-fluor-4-dimethylamino-azobenzol 
• 363-85-9 2-fluoro-tri-N-methyl-anilinium; iodide 
• 446-37-7 4-dimethylamino-3-fluoro-benzyl alcohol 

Relevant articles and documents

Additive-freeN-methylation of amines with methanol over supported iridium catalyst

An efficient and versatile zinc oxide-supported iridium (Ir/ZnO) catalyst was developed to catalyze the additive-freeN-methylation of amines with methanol. Mechanistic studies suggested that the high catalytic reactivity is rooted in the small sizes (1.4 nm) of Ir nanoparticles and the high ratio (93%) of oxidized iridium species (IrOx, Ir3+and Ir4+) on the catalyst. Moreover, the delicate cooperation between the IrOxand ZnO support also promoted its high reactivity. The selectivity of this catalyticN-methylation was controllable between dimethylation and monomethylation by carefully tuning the catalyst loading and reaction solvent. Specifically, neat methanol with high catalyst loading (2 mol% Ir) favored the formation ofN,N-dimethylated amine, while the mesitylene/methanol mixture with low catalyst loading (0.5 mol% Ir) was prone to producing mono-N-methylated amines. An environmentally benign continuous flow system with a recycled mode was also developed for the efficient production ofN-methylated amines. With optimal flow rates and amine concentrations, a variety ofN-methylamines were produced with good to excellent yields in this Ir/ZnO-based flow system, providing a starting point for the clean and efficient production ofN-methylamines with this cost-effective chemical process.

Method for preparing important chemicals by using lignin as methyl sources

The invention relates to preparation of important chemical products by using methoxyl groups in lignin. According to a method, methyl provided by the lignin reacts with carbon monoxide and water underthe catalysis effects of catalysts to obtain acetic acid; reaction is performed with aminated compounds to obtain N-methylation products. The methoxyl groups in the lignin are used for preparing important chemical products for the first time; an important and continuous production path is provided for the preparation of various important chemical products.

METHOD FOR THE METHYLATION OF NITROGEN-CONTAINING ORGANIC COMPOUNDS

A method for the methylation of amines, amides and imines comprises the step of reacting these compounds with CO2 and H2 in the presence of a Ruthenium-phosphine complex.