395-35-7

Basic information

• Product Name: 4-(TRIFLUOROMETHYL)MANDELIC ACID
• Synonyms: 4-(TRIFLUOROMETHYL)MANDELIC ACID;4-(trifluoromethyl)phenylglycolic acid;2-(4-(Trifluoromethyl)phenyl)-2-hydroxyacetic acid;4-(Trifluoromethyl)mandelicacid,98%;4-(trifluoromethyl)benzoglycolis acid;4-(Trifluoromethyl)mandelic acid 98%;4-(Trifluoromethyl)-α-hydroxybenzeneacetic acid;Hydroxy[4-(trifluoromethyl)phenyl]acetic acid
• CAS NO: 395-35-7
• Molecular Formula: C₉H₇F₃O₃
• Molecular Weight: 220.15
• EINECS: 206-900-1
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;C9;Carbonyl Compounds;Carboxylic Acids;Fluorine series
• Mol File: 395-35-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 130-134 °C
• Boiling Point: 324.2 °C at 760 mmHg
• Flash Point: 149.8 °C
• Appearance: white to almost white powder
• Density: 1.3670 (estimate)
• Vapor Pressure: 0.000102mmHg at 25°C
• Refractive Index: 1.502
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.06±0.10(Predicted)
• BRN: 2979949
• CAS DataBase Reference: 4-(TRIFLUOROMETHYL)MANDELIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(TRIFLUOROMETHYL)MANDELIC ACID(395-35-7)
• EPA Substance Registry System: 4-(TRIFLUOROMETHYL)MANDELIC ACID(395-35-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 395-35-7(Hazardous Substances Data)

Usage

Chemical Properties

white to almost white powder

General Description

Bismuth-catalyzed oxidation of 4-(trifluoromethyl)mandelic acid has been reported.

InChI:InChI=1/C9H7F3O3/c10-9(11,12)6-3-1-5(2-4-6)7(13)8(14)15/h1-4,7,13H,(H,14,15)

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 124-38-9 carbon dioxide 

Downstream Products

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 455-24-3 4-trifluoromethylbenzoic acid 
• 940952-12-5 S-acetyl-α-(p-trifluoromethylphenyl)-α-mercaptoacetic acid 
• 196302-06-4 (S)-4-(trifluoromethyl)mandelic acid 
• 51380-14-4 (R)-4-(trifluoromethyl)mandelic acid 
• 251366-96-8 2-hydroxy-2-(4-(trifluoromethyl)phenyl)acetamide 
• 79478-02-7 4-(trifluoromethyl)phenylglyoxylic acid 
• 1891-90-3 p-trifluoromethylbenzamide 
• 1301601-53-5 C₁₄H₁₃F₃O₄ 
• 1301601-42-2 methyl 2-(4-oxo-4-(pyrrolidin-1-yl)butoxy)-2-(4-(trifluoromethyl)phenyl)acetate 

Relevant articles and documents

Photocatalytic Carbinol Cation/Anion Umpolung: Direct Addition of Aromatic Aldehydes and Ketones to Carbon Dioxide

We have developed a new photocatalytic umpolung reaction of carbonyl compounds to generate anionic carbinol synthons. Aromatic aldehydes or ketones reacted with carbon dioxide in the presence of an iridium photocatalyst and 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzimidazole (DMBI) as a reductant under visible-light irradiation to furnish the corresponding α-hydroxycarboxylic acids through nucleophilic addition of the resulting carbinol anions to electrophilic carbon dioxide.

7-(D-α-Hydroxy-2-arylacetamido)-3-(2-carboxyalkyl-2,3-dihydro-s-triazolo-[4,3-b]pyridazin-3-on-6-ylthiomethyl)-3-cephem-4-carboxylic acids and derivatives

7-(D-α-Hydroxy-2-arylacetamido)-3-(2-carboxyalkyl-2,3-dihydro-s-triazolo[4,3-b]pyridazin-3-on-6-ylthiomethyl)-3-cephem-4-carboxylic acids and derivatives containing blocking groups on the α-hydroxy group and their nontoxic, pharmaceutically acceptable salts are valuable as antibacterial agents and are particularly valuable as therapeutic agents in poultry and in animals, including man, in the treatment of infectious diseases caused by many Gram-positive and Gram-negative bacteria. A preferred compound is 7-(D-mandelamido)-3-(2-carboxyalkyl-2,3-dihydro-s-triazolo[4,3-b]pyridazin-3-on-6-ylthiomethyl)-3-cephem-4-carboxylic acid.