395-36-8 Usage
Description
N-(3-chloro-2-fluorophenyl)acetamide is a chemical compound with the molecular formula C8H7ClFNO. It is an amide derivative of 3-chloro-2-fluorophenylacetic acid and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. N-(3-chloro-2-fluorophenyl)acetamide may also have potential applications in the field of organic chemistry as a building block for more complex molecules. N-(3-chloro-2-fluorophenyl)acetamide is a solid, white to off-white powder with a molecular weight of 189.6 g/mol. It is important to handle and store this chemical with proper safety precautions due to its potential reactivity and health hazards.
Uses
Used in Pharmaceutical Industry:
N-(3-chloro-2-fluorophenyl)acetamide is used as an intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into the structure of various medicinal compounds, potentially enhancing their therapeutic properties and effectiveness.
Used in Agrochemical Industry:
N-(3-chloro-2-fluorophenyl)acetamide is used as an intermediate in the synthesis of agrochemicals to develop new pesticides or herbicides, contributing to more effective crop protection and management strategies.
Used in Organic Chemistry:
N-(3-chloro-2-fluorophenyl)acetamide is used as a building block in organic chemistry for the creation of more complex molecules, facilitating the development of novel chemical entities with diverse applications in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 395-36-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,9 and 5 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 395-36:
(5*3)+(4*9)+(3*5)+(2*3)+(1*6)=78
78 % 10 = 8
So 395-36-8 is a valid CAS Registry Number.
395-36-8Relevant articles and documents
The fight against the influenza A virus H1N1: Synthesis, molecular modeling, and biological evaluation of benzofurazan derivatives as viral RNA polymerase inhibitors
Pagano, Mafalda,Castagnolo, Daniele,Bernardini, Martina,Fallacara, Anna Lucia,Laurenzana, Ilaria,Deodato, Davide,Kessler, Ulrich,Pilger, Beatrice,Stergiou, Lilli,Strunze, Stephan,Tintori, Cristina,Botta, Maurizio
, p. 129 - 150 (2014/01/17)
The influenza RNA polymerase complex, which consists of the three subunits PA, PB1, and PB2, is a promising target for the development of new antiviral drugs. A large library of benzofurazan compounds was synthesized and assayed against influenza virus A/WSN/33 (H1N1). Most of the new derivatives were found to act by inhibiting the viral RNA polymerase complex through disruption of the complex formed between subunits PA and PB1. Docking studies were also performed to elucidate the binding mode of benzofurazans within the PB1 binding site in PA and to identify amino acids involved in their mechanism of action. The predicted binding pose is fully consistent with the biological data and lays the foundation for the rational development of more effective PA-PB1 inhibitors. In the fight against influenza virus A/WSN/33 (H1N1), the PA-PB1 protein-protein interaction is emerging as a new drug target. To identify small molecules able to inhibit the viral RNA polymerase complex, the benzofurazan scaffold was explored by synthesizing a large library of derivatives. Some compounds showed high anti-H1N1 activity and emerged as effective inhibitors of the PA-PB1 interaction, with IC50 values in the micromolar range. Copyright