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395-44-8 Usage

Uses

Different sources of media describe the Uses of 395-44-8 differently. You can refer to the following data:
1. 2-(Trifluoromethyl)Benzyl Bromide (cas# 395-44-8) is a useful research chemical.
2. 2-(Trifluoromethyl)benzyl bromide may be used in chemical synthesis.

Chemical Properties

Colorless to light yellow liqui

Check Digit Verification of cas no

The CAS Registry Mumber 395-44-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,9 and 5 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 395-44:
(5*3)+(4*9)+(3*5)+(2*4)+(1*4)=78
78 % 10 = 8
So 395-44-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H7F3/c1-2-7-5-3-4-6-8(7)9(10,11)12/h2-6H,1H2

395-44-8 Well-known Company Product Price

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  • Alfa Aesar

  • (B20634)  2-(Trifluoromethyl)benzyl bromide, 97+%   

  • 395-44-8

  • 1g

  • 194.0CNY

  • Detail
  • Alfa Aesar

  • (B20634)  2-(Trifluoromethyl)benzyl bromide, 97+%   

  • 395-44-8

  • 5g

  • 668.0CNY

  • Detail
  • Alfa Aesar

  • (B20634)  2-(Trifluoromethyl)benzyl bromide, 97+%   

  • 395-44-8

  • 25g

  • 2912.0CNY

  • Detail

395-44-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(bromomethyl)-2-(trifluoromethyl)benzene

1.2 Other means of identification

Product number -
Other names 2-(Trifluoromethyl)benzyl Bromide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:395-44-8 SDS

395-44-8Synthetic route

diethyl 2,6-dimethyl-4-(2-(trifluoromethyl)benzyl)-1,4-dihydropyridine-3,5-dicarboxylate

diethyl 2,6-dimethyl-4-(2-(trifluoromethyl)benzyl)-1,4-dihydropyridine-3,5-dicarboxylate

o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

Conditions
ConditionsYield
With dipotassium peroxodisulfate; tris(2,2′-bipyridyl)dichlororuthenium(II) hexahydrate; sodium bromide In water; acetonitrile at 20℃; for 24h; Sealed tube; Inert atmosphere; Irradiation; regioselective reaction;62%
(2-(trifluoromethyl)phenyl)methanol
346-06-5

(2-(trifluoromethyl)phenyl)methanol

o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

Conditions
ConditionsYield
(bromination);
With pyridine; phosphorus tribromide at -10 - -5℃;
With sulfuric acid; hydrogen bromide
With carbon tetrabromide; triphenylphosphine In dichloromethane for 2h; Substitution; reflux;
With phosphorus tribromide In dichloromethane; water; toluene
[2-(trifluoromethyl)phenyl]magnesium bromide
395-47-1

[2-(trifluoromethyl)phenyl]magnesium bromide

o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: (bromination)
View Scheme
2-trifluoromethylbenzoic acid
433-97-6

2-trifluoromethylbenzoic acid

o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: LiAlH4 / diethyl ether
2: PBr3, Py / -10 - -5 °C
View Scheme
2-trifluoromethylphenylmagnesium chloride
3796-19-8

2-trifluoromethylphenylmagnesium chloride

o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: aq. HBr, H2SO4
View Scheme
2-Trifluoromethylbenzaldehyde
447-61-0

2-Trifluoromethylbenzaldehyde

o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetra(n-butyl)ammonium hydrogensulfate / ethylene glycol / 4 h / 80 °C / Sealed tube; Inert atmosphere
2: sodium bromide; dipotassium peroxodisulfate; tris(2,2′-bipyridyl)dichlororuthenium(II) hexahydrate / acetonitrile; water / 24 h / 20 °C / Sealed tube; Inert atmosphere; Irradiation
View Scheme
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

triphenylphosphine
603-35-0

triphenylphosphine

2-trifluoromethylbenzyltriphenylphosphonium bromide

2-trifluoromethylbenzyltriphenylphosphonium bromide

Conditions
ConditionsYield
In toluene for 12h; Reflux;100%
In toluene Reflux;77%
In toluene at 80℃; for 16h;
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

A

6-((2-(trifluoromethyl)benzyl)thio)-9H-purine

6-((2-(trifluoromethyl)benzyl)thio)-9H-purine

B

9-[2-(trifluoromethyl) benzyl]-6-[(2-(trifluoromethyl)benzyl)thio]-9H-purine

9-[2-(trifluoromethyl) benzyl]-6-[(2-(trifluoromethyl)benzyl)thio]-9H-purine

Conditions
ConditionsYield
Stage #1: 6-Mercaptopurine With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 1h;
Stage #2: o-trifluoromethylbenzyl bromide In N,N-dimethyl-formamide at 20℃; Further stages;
A 91%
B 99%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

Quinoline-2-thiol
2637-37-8

Quinoline-2-thiol

2-((2-(trifluoromethyl)benzyl)thio)quinoline

2-((2-(trifluoromethyl)benzyl)thio)quinoline

Conditions
ConditionsYield
Stage #1: Quinoline-2-thiol With 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 20℃; for 0.5h;
Stage #2: o-trifluoromethylbenzyl bromide In toluene at 20℃; for 17h;
99%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

m-nitrobenzene boronic acid
13331-27-6

m-nitrobenzene boronic acid

1-(3-nitrobenzyl)-2-(trifluoromethyl)benzene
886211-35-4

1-(3-nitrobenzyl)-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,2-dimethoxyethane; water at 50℃; for 16h;98%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

5-bromosalicyclaldehyde
1761-61-1

5-bromosalicyclaldehyde

5-bromo-2-[2-(trifluoromethyl)benzyloxy]benzaldehyde
1198307-34-4

5-bromo-2-[2-(trifluoromethyl)benzyloxy]benzaldehyde

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃;98%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

phenylboronic acid
98-80-6

phenylboronic acid

1-benzyl-2-(trifluoromethyl)benzene
7552-71-8

1-benzyl-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
With trans-(imidazole-κN)diiodo(3-isopropylbenzothiazolin-2-ylidene)palladium(II); potassium carbonate In water; N,N-dimethyl-formamide at 60℃; for 2h; Suzuki-Miyaura coupling;98%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

methyl 2-cyanoacetate
105-34-0

methyl 2-cyanoacetate

methyl 2-cyano-3-[2-(trifluoromethyl)phenyl]-2-{[2-(trifluoromethyl)phenyl]methyl}propionate

methyl 2-cyano-3-[2-(trifluoromethyl)phenyl]-2-{[2-(trifluoromethyl)phenyl]methyl}propionate

Conditions
ConditionsYield
Stage #1: methyl 2-cyanoacetate With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 0℃; for 0.0333333h;
Stage #2: o-trifluoromethylbenzyl bromide In dichloromethane at 0 - 20℃;
98%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃;
ethyl 6-(4-fluorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-4-pyridazinecarboxylate
1040543-17-6

ethyl 6-(4-fluorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-4-pyridazinecarboxylate

o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

ethyl 6-(4-fluorophenyl)-5-hydroxy-3-oxo-2-{[2-(trifluoromethyl)phenyl]methyl}-2,3-dihydro-4-pyridazinecarboxylate
1040544-19-1

ethyl 6-(4-fluorophenyl)-5-hydroxy-3-oxo-2-{[2-(trifluoromethyl)phenyl]methyl}-2,3-dihydro-4-pyridazinecarboxylate

Conditions
ConditionsYield
Stage #1: ethyl 6-(4-fluorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-4-pyridazinecarboxylate With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 0.75h;
Stage #2: o-trifluoromethylbenzyl bromide In N,N-dimethyl-formamide at 0 - 20℃; for 3h;
Stage #3: With hydrogenchloride In water; N,N-dimethyl-formamide at 20℃;
97%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

4-methoxy-2-nitroaniline
96-96-8

4-methoxy-2-nitroaniline

4-methoxy-2-nitro-N-(2-(trifluoromethyl)benzyl)aniline

4-methoxy-2-nitro-N-(2-(trifluoromethyl)benzyl)aniline

Conditions
ConditionsYield
Stage #1: 4-methoxy-2-nitroaniline With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 0.5h; Inert atmosphere;
Stage #2: o-trifluoromethylbenzyl bromide In N,N-dimethyl-formamide at 90℃; Inert atmosphere;
97%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

N-(tert-butoxycarbonyl)-3-hydroxypyrrolidine
103057-44-9

N-(tert-butoxycarbonyl)-3-hydroxypyrrolidine

(±)-tert-butyl 3-((2-(trifluoromethyl)benzyl)oxy)pyrrolidine-1-carboxylate

(±)-tert-butyl 3-((2-(trifluoromethyl)benzyl)oxy)pyrrolidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: N-(tert-butoxycarbonyl)-3-hydroxypyrrolidine With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h; Inert atmosphere;
Stage #2: o-trifluoromethylbenzyl bromide In N,N-dimethyl-formamide at 0 - 25℃; for 16h; Inert atmosphere;
97%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

N-(diphenylmethylene)glycine tert-butyl ester
81477-94-3

N-(diphenylmethylene)glycine tert-butyl ester

(S)-tert-butyl 3-(2-trifluoromethylphenyl)-2-(diphenylmethyleneamino)propanoate

(S)-tert-butyl 3-(2-trifluoromethylphenyl)-2-(diphenylmethyleneamino)propanoate

Conditions
ConditionsYield
With C58H42F12N(1+)*Br(1-); potassium hydroxide In water; toluene at -20℃; for 3h; Reagent/catalyst; enantioselective reaction;96%
With C30H32N3O(1+)*Br(1-); potassium hydroxide In water; toluene at -40℃; for 10h; Reagent/catalyst; enantioselective reaction;95%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

trimethylphosphane
594-09-2

trimethylphosphane

trimethyl(2-(trifluoromethyl)benzyl)phosphonium bromide

trimethyl(2-(trifluoromethyl)benzyl)phosphonium bromide

Conditions
ConditionsYield
In toluene; acetonitrile at 20℃; for 1h; Inert atmosphere;96%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

C45H45F3N2O6

C45H45F3N2O6

Conditions
ConditionsYield
With triethylhexadecylammonium chloride In water at 200℃; for 0.1h; Reagent/catalyst; Solvent; Temperature;95.81%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

1-(azidomethyl)-2-(trifluoromethyl)benzene
823189-03-3

1-(azidomethyl)-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
With sodium azide In water; tert-butyl alcohol95.8%
With sodium azide In water; acetone90%
With sodium azide In water; acetone at 22℃;87%
3,4-dihydro-2(1H)-quinolone
553-03-7

3,4-dihydro-2(1H)-quinolone

o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

1-[2-(trifluoromethyl)benzyl]-3,4-dihydroquinolin-2(1H)-one
1247021-75-5

1-[2-(trifluoromethyl)benzyl]-3,4-dihydroquinolin-2(1H)-one

Conditions
ConditionsYield
Stage #1: 3,4-dihydro-2(1H)-quinolone With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃;
Stage #2: o-trifluoromethylbenzyl bromide In N,N-dimethyl-formamide at 20℃;
95%
(3α,5α)-3-hydroxy-3-(piperazin-1-ylmethyl)androstan-17-one
1326702-42-4

(3α,5α)-3-hydroxy-3-(piperazin-1-ylmethyl)androstan-17-one

o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

(3α,5α)-3-hydroxy-3-((4-[2-(trifluoromethyl)benzyl]-piperazin-1-yl)methyl)androstan-17-one
1326702-55-9

(3α,5α)-3-hydroxy-3-((4-[2-(trifluoromethyl)benzyl]-piperazin-1-yl)methyl)androstan-17-one

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃;95%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl isoselenuronium bromide
50793-60-7

2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl isoselenuronium bromide

2-(trifluoromethyl)benzyl 2,3,4,6-tetra-O-acetyl-1-seleno-β-D-glucopyranoside
1383478-50-9

2-(trifluoromethyl)benzyl 2,3,4,6-tetra-O-acetyl-1-seleno-β-D-glucopyranoside

Conditions
ConditionsYield
With triethylamine at 20℃;95%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

C18H21NO
115-46-8

C18H21NO

(1-(2-(trifluoromethyl)benzyl)piperidin-4-yl)diphenylmethanol

(1-(2-(trifluoromethyl)benzyl)piperidin-4-yl)diphenylmethanol

Conditions
ConditionsYield
With triethylamine In acetonitrile at 70℃; for 4h;95%
Na[CpMo(CO)3]
12107-35-6

Na[CpMo(CO)3]

o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

[CpMo(CO)3Bz-o-CF3]

[CpMo(CO)3Bz-o-CF3]

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 24h;95%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

mercaptoacetic acid
68-11-1

mercaptoacetic acid

2-[2-(trifluoromethyl)benzylthio]acetic acid

2-[2-(trifluoromethyl)benzylthio]acetic acid

Conditions
ConditionsYield
With sodium hydroxide In methanol at 20℃; for 1h;94.5%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

4-methylphenylboronic acid
5720-05-8

4-methylphenylboronic acid

1-(4-methylbenzyl)-2-(trifluoromethyl)benzene
1130704-36-7

1-(4-methylbenzyl)-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
With trans-(benzimidazole-κN)diiodo(3-isopropylbenzothiazolin-2-ylidene)palladium(II); potassium carbonate In water; N,N-dimethyl-formamide at 60℃; for 17h; Suzuki-Miyaura coupling;94%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

N-t-butoxycarbonyl-tyramine
64318-28-1

N-t-butoxycarbonyl-tyramine

tert-butyl (4-((2-(trifluoromethyl)benzyl)oxy)phenethyl)carbamate

tert-butyl (4-((2-(trifluoromethyl)benzyl)oxy)phenethyl)carbamate

Conditions
ConditionsYield
With potassium carbonate In acetone for 4h; Williamson Ether Synthesis; Reflux;94%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

N-(diphenylmethylene)glycine tert-butyl ester
81477-94-3

N-(diphenylmethylene)glycine tert-butyl ester

(R)-tert-butyl 3-(2-trifluoromethylphenyl)-2-(diphenylmethyleneamino)propanoate

(R)-tert-butyl 3-(2-trifluoromethylphenyl)-2-(diphenylmethyleneamino)propanoate

Conditions
ConditionsYield
With C28H28F6N3(1+)*Br(1-); potassium hydroxide In diethyl ether; water at -40℃; for 5h; enantioselective reaction;93%
4-tert-Butylstyrene
1746-23-2

4-tert-Butylstyrene

o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

butan-1-ol
71-36-3

butan-1-ol

1-(3-butoxy-3-(4-tert-butylphenyl)propyl)-2-(trifluoromethyl)benzene

1-(3-butoxy-3-(4-tert-butylphenyl)propyl)-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
With sodium carbonate; copper(l) chloride at 100℃; for 24h; Inert atmosphere; Schlenk technique;93%
2-(4-chlorophenoxy)-1,3-propanedioic acid diethyl ester
24101-91-5

2-(4-chlorophenoxy)-1,3-propanedioic acid diethyl ester

o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

diethyl 2-(4-chlorophenoxy)-2-[2-(trifluormethyl)benzyl]malonate
1093231-91-4

diethyl 2-(4-chlorophenoxy)-2-[2-(trifluormethyl)benzyl]malonate

Conditions
ConditionsYield
Stage #1: 2-(4-chlorophenoxy)-1,3-propanedioic acid diethyl ester With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 0.333333h;
Stage #2: o-trifluoromethylbenzyl bromide In N,N-dimethyl-formamide at 20 - 60℃;
92%
1,1-dimethylethyl (3S)-3-[(3-chloro-4-cyanophenyl)amino]-1-pyrrolidnecarboxylate
940865-64-5

1,1-dimethylethyl (3S)-3-[(3-chloro-4-cyanophenyl)amino]-1-pyrrolidnecarboxylate

o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

1,1-dimethylethyl (3S)-3-((3-chloro-4-cyanophenyl){[2-(trifluoromethyl)phenyl]methyl}amino)-1-pyrrolidinecarboxylate
940865-65-6

1,1-dimethylethyl (3S)-3-((3-chloro-4-cyanophenyl){[2-(trifluoromethyl)phenyl]methyl}amino)-1-pyrrolidinecarboxylate

Conditions
ConditionsYield
Stage #1: 1,1-dimethylethyl (3S)-3-[(3-chloro-4-cyanophenyl)amino]-1-pyrrolidnecarboxylate With sodium hydride In N,N-dimethyl-formamide for 1h; Cooling with ice;
Stage #2: o-trifluoromethylbenzyl bromide In N,N-dimethyl-formamide at 0 - 25℃; for 1h;
92%
Stage #1: 1,1-dimethylethyl (3S)-3-[(3-chloro-4-cyanophenyl)amino]-1-pyrrolidnecarboxylate With sodium hydride In hexane; N,N-dimethyl-formamide at 0℃; for 1h;
Stage #2: o-trifluoromethylbenzyl bromide In N,N-dimethyl-formamide at 0 - 20℃; for 0.5h;
Stage #3: With water; ammonium chloride In N,N-dimethyl-formamide
92%
Stage #1: 1,1-dimethylethyl (3S)-3-[(3-chloro-4-cyanophenyl)amino]-1-pyrrolidnecarboxylate With sodium hydride In N,N-dimethyl-formamide; mineral oil
Stage #2: o-trifluoromethylbenzyl bromide In N,N-dimethyl-formamide; mineral oil
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

(S)-1-(2,6-diisopropylphenyl)-4-isopropyl-4,5-dihydro-1H-imidazole

(S)-1-(2,6-diisopropylphenyl)-4-isopropyl-4,5-dihydro-1H-imidazole

(S)-1-(2,6-diisopropylphenyl)-4-isopropyl-3-(2-(trifluoromethyl)benzyl)-4,5-dihydro-1Himidazol-3-ium bromide

(S)-1-(2,6-diisopropylphenyl)-4-isopropyl-3-(2-(trifluoromethyl)benzyl)-4,5-dihydro-1Himidazol-3-ium bromide

Conditions
ConditionsYield
In toluene at 100℃; for 1h;92%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

(3aS,9bR)-8-hydroxy-6,9-dimethyl-3-methylene-3a,4,5,9b-tetrahydronaphtho[1,2-b]furan-2(3H)-one

(3aS,9bR)-8-hydroxy-6,9-dimethyl-3-methylene-3a,4,5,9b-tetrahydronaphtho[1,2-b]furan-2(3H)-one

(3aS,9bR)-6,9-dimethyl-3-methylene-8-((2-(trifluoromethyl)-benzyl)oxy)-3a,4,5,9b-tetrahydronaphtho[1,2-b]furan-2(3H)-one

(3aS,9bR)-6,9-dimethyl-3-methylene-8-((2-(trifluoromethyl)-benzyl)oxy)-3a,4,5,9b-tetrahydronaphtho[1,2-b]furan-2(3H)-one

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃;92%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

ethyl 1-(2-fluoropyridin-4-yl)-4-hydroxy-1H-pyrazole-3-carboxylate

ethyl 1-(2-fluoropyridin-4-yl)-4-hydroxy-1H-pyrazole-3-carboxylate

C19H15F4N3O3

C19H15F4N3O3

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 0℃; for 1h;92%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

C14H14N2O3

C14H14N2O3

3-(4-(2-(trifluoromethyl)benzyl)piperazine-1-carbonyl)-2H-chromen-2-one

3-(4-(2-(trifluoromethyl)benzyl)piperazine-1-carbonyl)-2H-chromen-2-one

Conditions
ConditionsYield
With triethylamine In acetonitrile for 8h; Reflux;91%

395-44-8Relevant articles and documents

Synthesis of Alkyl Halides from Aldehydes via Deformylative Halogenation

Liang, Shengzong,Kumon, Tatsuya,Angnes, Ricardo A.,Sanchez, Melissa,Xu, Bo,Hammond, Gerald B.

, p. 3848 - 3854 (2019/05/24)

An unprecedented deformylative halogenation of aldehydes to alkyl halides is presented. Under oxidative conditions, 1,4-dihydropyridine (DHP), derived from an aldehyde, generated a C(sp3)- radical that coupled with a halogen radical that was generated from inexpensive and atom-economical halogen sources (NaBr, NaI, or HCl), to yield an alkyl halide. Because of the mild conditions, a wide range of functional groups were tolerated, and excellent site selectivity was achieved.

Sulfonamides and uses

-

, (2008/06/13)

Sulfonamides of formula I, in which the symbols R1 -R6, X, Y and n have the significance given in the description and which are in part novel compounds, and salts thereof, which can be used as active ingredients for the manufacture of medicaments for the treatment of circulatory disorders, especially hypertension, ischemia, vasospasms and angina pectoris, are described.

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