396098-84-3Relevant articles and documents
One-pot B(C6F5)3 catalyzed cascade synthesis of 2-substituted-2,3-dihydroquinazolin-4(1H)-ones
Shinde, Achut R.,Mane, Yogesh D.,Muley, Dnyanoba B.
supporting information, p. 33 - 40 (2019/11/19)
A new and efficient B(C6F5)3 catalyzed domino strategy has been developed for the synthesis of 2-substituted quinazolinones. The reaction utilizes 2-aminobenzamide and aldehydes for a one-pot protocol. A wide range of substrate scope, functional group tolerance, and operational simplicity with excellent yield are synthetically useful features.
Phosphotungstic acid mediated, microwave assisted solvent-free green synthesis of highly functionalized 2?-spiro and 2, 3-dihydro quinazolinone and 2-methylamino benzamide derivatives from aryl and heteroaryl 2-amino amides
Novanna, Motakatla,Kannadasan, Sathananthan,Shanmugam, Ponnusamy
supporting information, p. 201 - 206 (2018/12/13)
Phosphotungstic acid has been found as green catalyst for the synthesis of spiro and cyclized quinazolinones and 2-amino substituted carboxamide under microwave irradiation and solvent-free condition has been developed. The scope of the reaction has been demonstrated for a variety of aldehydes and ketones with O-amino amides such as 2-amino-benzamide, 2-amino-5-iodo benzamide, 3-aminothiophene-2-carboxamide, 3-aminobenzofuran-2-carboxamide and 2-aminopyridine-3-carboxamides. The reaction afforded spiro-, cyclized quinazolinones and 2-amino substituted carboxamide derivatives within few minutes of irradiation in excellent yield. Plausible mechanism for the formation of products is provided. Synthetic utility of 1′H-spiro[fluorene-9,2′-quinazolin]-4′(3′H)-one 3a has been demonstrated by synthesis of 1,4-di(1′H-spiro[fluorene-9,2′-quinazolin]-4′(3′H)-one) buta-1,3-diyne 12, 1′-((1-benzyl-1H-1,2,3-triazol-4-yl) methyl)-1′H-spiro[fluorene-9,2′-quinazolin]-4′(3′H)-one 13 and 1′-phenyl-1′H-spiro[fluorene-9,2′-quinazolin]-4′(3′H)-one 14 under standard protocols.
A concise aqueous phase supramolecular synthesis of 2-phenyl-2,3- dihydroquinazolin-4(1H)-one derivatives
Ramesh,Karnakar,Satish,Anil Kumar,Nageswar
supporting information, p. 6936 - 6939 (2013/01/15)
2-Phenyl-2,3-dihydroquinazolin-4(1H)-one derivatives were synthesized for the first time in water under neutral conditions by the reaction of aldehyde, and anthranilamide mediated by β-cyclodextrin in high yields. β-Cyclodextrin can be recovered and reused with a small loss of catalytic activity.
