39642-87-0

Basic information

• Product Name: 1,3-bis(pyridin-4-yl)urea
• Synonyms: 1,3-bis(pyridin-4-yl)urea
• CAS NO: 39642-87-0
• Molecular Weight: 214.227
• Mol File: 39642-87-0.mol
• Article Data: 12

Chemical Properties

• Melting Point: 208 °C
• Boiling Point: 299.3±15.0 °C(Predicted)
• Density: 1.370±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1,3-bis(pyridin-4-yl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-bis(pyridin-4-yl)urea(39642-87-0)
• EPA Substance Registry System: 1,3-bis(pyridin-4-yl)urea(39642-87-0)

Safety Data

• Hazardous Substances Data: 39642-87-0(Hazardous Substances Data)

Usage

General Description

1,3-bis(pyridin-4-yl)urea is a chemical compound with the formula C12H10N4O. It is a urea derivative and consists of two pyridine rings connected to a central urea group. 1,3-bis(pyridin-4-yl)urea is commonly used as a building block for organic synthesis and can be found in pharmaceuticals, agrochemicals, and materials science. It has been studied for its potential antifungal and antibacterial properties, and also shows promise in the development of materials such as liquid crystals and fluorescent dyes. 1,3-bis(pyridin-4-yl)urea has also been investigated for its potential application in the field of cancer research and drug development. Overall, this compound has a wide range of potential uses in various scientific and industrial applications.

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Relevant articles and documents

Solvent-Induced Reversible Spin-Crossover in a 3D Hofmann-Type Coordination Polymer and Unusual Enhancement of the Lattice Cooperativity at the Desolvated State

The new 3D Hofmann-type coordination polymer [Fe(dpyu){Pt(CN)4}]·9H2O [dpyu = 1,3-di(pyridin-4-yl)urea] exhibits reversible interchange between two- and one-step spin-crossover behavior, associated with desorption/resorption of lattice water molecules. Solvent water removal also induces an increase of the spin-transition temperature, indicating strong lattice cooperativity, observed for the first time in a 3D Hofmann-type coordination polymer.

Investigation of the anticancer activity of coordination-driven self-assembledtwo-dimensional ruthenium metalla-rectangle

Coordination-driven self-assembly is an effective synthetic tool for the construction of spatially and electronically tunable supramolecular coordination complexes (SCCs), which are useful in various applications. Herein, we report the synthesis of a two-dimensional discrete metalla-rectangle [(η6-p-cymene)4Ru4(C6H2O4)2(2)2](CF3SO3)4 (3) by the reaction of a dinuclear half-sandwich ruthenium (II) complex [Ru2(η6-p-cymene)2(C6H2O4)Cl2] (1) and bis-pyridyl amide linker (2) in the presence of AgO3SCF3. This cationic ruthenium metalla-rectangle (3) has been isolated as its triflate salt and characterized by analytical techniques including elemental analysis, Fourier-transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance spectroscopy (1H-NMR), carbon nuclear magnetic resonance spectroscopy (13C-NMR), 1H-1H correlation spectroscopy (COSY), 1H-1H nuclear Overhauser effect spectroscopy (NOESY), diffusion ordered spectroscopy (DOSY), and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). Significantly, the 2D cationic ruthenium metalla-rectangle showed better anticancer activity towards three different cell lines (A549, Caki-1 and Lovo) as compared with the parent ruthenium complex (1) and the commercially used drug, cisplatin.

The targeted design of dual-functional metal-organic frameworks (DF-MOFs) as highly efficient adsorbents for Hg2+ ions: Synthesis for purpose

Designing adsorbents with accessible chelating sites and achieving high contaminant purification efficiency are still important to overcome environmental remediation challenges. As one of the significant global concerns, the presence of heavy metal ions i

Anchoring Drugs to a Zinc(II) Coordination Polymer Network: Exploiting Structural Rationale toward the Design of Metallogels for Drug-Delivery Applications

A new series of coordination polymers (CPs) were synthesized and crystallographically characterized by single-crystal X-ray diffraction with the aim of developing drug-delivery systems via metallogel formation. Structural rationale was employed to design such coordination-polymer-based metallogels. As many as nine CPs were obtained by reacting two bis(pyridyl)urea ligands, namely, 1,3-dipyridin-3-ylurea (3U) and 1,3-dipyridin-4-ylurea (4U), and the sodium salt of various nonsteroidal antiinflammatory drugs, namely, ibuprofen (IBU), naproxen (NAP), fenoprofen (FEN), diclofenac (DIC), meclofenamic acid (MEC), mefenamic acid (MEF), and Zn(NO3)2. All of the CPs displayed 1D polymeric chains that were self-assembled through various hydrogen-bonding interactions involving the urea N-H and carboxylate O atoms and, in a few cases, lattice-occluded water molecules. The reacting components of the CPs produced five metallogels in dimethyl sulfoxide/water. The gels were characterized by rheology and transmission electron microscopy. Three selected metallogelators, namely, 3UMEFg, 3UNAPg, and 3UMECg, showed in vitro anticancer, cell imaging, and multidrug delivery for antibacterial applications, respectively. The shear-thinning properties of 3UMECg (rheoreversibility and injectability) make it a potential candidate for plausible topical application.