39728-80-8

Basic information

• Product Name: 4-(4-hydroxy-3-methoxyphenyl)butan-2-ol
• Synonyms: 4-(4-hydroxy-3-methoxyphenyl)butan-2-ol;3-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)butane;4-(3-Methoxy-4-hydroxyphenyl)-2-butanol;4-(4-Hydroxy-3-methoxyphenyl)-2-butanol;4-Hydroxy-3-methoxy-α-methylbenzenepropan-1-ol;Zingerol;4-(3-hydroxybutyl)-2-methoxyphenol;2-Hydroxy-5-(3-hydroxybut-1-yl)anisole
• CAS NO: 39728-80-8
• Molecular Formula: C₁₁H₁₆O₃
• Molecular Weight: 196.24294
• EINECS: 254-607-2
• Mol File: 39728-80-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 344.4°Cat760mmHg
• Flash Point: 162.1°C
• Appearance: /
• Density: 1.117g/cm³
• Vapor Pressure: 2.51E-05mmHg at 25°C
• Refractive Index: 1.54
• CAS DataBase Reference: 4-(4-hydroxy-3-methoxyphenyl)butan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-hydroxy-3-methoxyphenyl)butan-2-ol(39728-80-8)
• EPA Substance Registry System: 4-(4-hydroxy-3-methoxyphenyl)butan-2-ol(39728-80-8)

Safety Data

• Hazardous Substances Data: 39728-80-8(Hazardous Substances Data)

Usage

General Description

4-(4-hydroxy-3-methoxyphenyl)butan-2-ol, also known as HHPB, is a chemical compound with the molecular formula C13H18O3. It is an organic compound that belongs to the class of phenolic alcohols. HHPB is commonly found in various natural sources, such as plants and fruits, and is known for its antioxidant properties. This chemical is used in the production of pharmaceuticals, cosmetics, and food products due to its ability to scavenge free radicals and prevent oxidative damage. It is also being studied for its potential health benefits, such as anti-inflammatory and anti-cancer properties. HHPB is considered to be a safe and beneficial compound with a wide range of applications in various industries.

InChI:InChI=1/C11H16O3/c1-8(12)3-4-9-5-6-10(13)11(7-9)14-2/h5-8,12-13H,3-4H2,1-2H3

Upstream product

• 1080-12-2 Dehydrozingerone 
• 56700-87-9 4-(3-methoxy-4-trimethylsilyloxyphenyl)butan-2-one 
• 64-17-5 ethanol 
• 1080-12-2 (E)-4-(4-hydroxy-3-methoxyphenyl)but-3-ene-2-one 
• 917-64-6 methyl magnesium iodide 
• 80638-48-8 3-(3'-methoxy-4'-hydroxyphenyl)propionaldehyde 
• 121-33-5 vanillin 
• 122-48-5 4-(4-hydroxy-3-methoxyphenyl)-2-butanone 
• 66-25-1 hexanal 
• 141-78-6 ethyl acetate 

Downstream Products

• 1443152-50-8 (S)-4-(4'-acetyloxy-3'-methoxyphenyl)-2-butanol 
• 1443152-51-9 (R)-4-(4'-hydroxy-3'-methoxyphenyl)-2-butyl acetate 
• 1450832-91-3 (S)-4-(4'-hydroxy-3'-methoxyphenyl)-2-butyl acetate 
• 960357-43-1 4-(2-benzyl-4-hydroxy-5-methoxyphenyl)butan-2-one 
• 960357-42-0 4-[2-(4-nitrobenzyl)-4-hydroxy-5-methoxyphenyl]butan-2-one 

Relevant articles and documents

Zingerone in the flower of passiflora maliformis attracts an australian fruit fly, bactrocera jarvisi (Tryon)

Passiflora maliformis is an introduced plant in Australia but its flowers are known to attract the native Jarvis’s fruit fly, Bactrocera jarvisi (Tryon). The present study identifies and quantifies likely attractant(s) of male B. jarvisi in P. maliformis

Synthesis of raspberry and ginger ketones by nickel boride-catalyzed hydrogenation of 4-arylbut-3-en-2-ones

Raspberry and ginger ketones have been synthesized in good yield by the hydrogenation of the corresponding unsaturated precursors 4-(4′- hydroxyphenyl)but-3-en-2-one and 4-(4′-hydroxy-3′-methoxyphenyl)but- 3-en-2-one, respectively, using a freshly prepared suspension of nickel boride in methanol as catalyst.

Asymmetric synthesis of enantiomerically pure zingerols by lipase-catalyzed transesterification and efficient synthesis of their analogues

The achiral zingerone 1, readily available from ginger, can be easily transformed into chiral derivatives. Zingerol 2, a reduced product of zingerone 1 is expected to be an important new medicinal lead compound. We have achieved a concise synthesis of optically active zingerol (R)-2 and (S)-2 by the lipase-catalyzed stereoselective transesterification of racemic 2. Under the optimized conditions, a lipase from Alcaligenes sp. (Meito QLM) and vinyl acetate in i-Pr2O or hexane at 35 C within 1 h gave the alcohol (S)-2 and the acetate (R)-9 with high enantioselectivity without producing acetylated by-products. Since optically active (S)-2 and (R)-9 were obtained through lipase-catalyzed transesterification, other enantiomerically pure novel compounds could all be synthesized.