398470-86-5

Basic information

• Product Name: 3-(3,4-dihydroisoquinolin-2(1H)-yl)-N-(4-ethoxyphenyl)propanamide
• CAS NO: 398470-86-5
• Molecular Weight: 324.423
• Mol File: 398470-86-5.mol

Chemical Properties

• CAS DataBase Reference: 3-(3,4-dihydroisoquinolin-2(1H)-yl)-N-(4-ethoxyphenyl)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,4-dihydroisoquinolin-2(1H)-yl)-N-(4-ethoxyphenyl)propanamide(398470-86-5)
• EPA Substance Registry System: 3-(3,4-dihydroisoquinolin-2(1H)-yl)-N-(4-ethoxyphenyl)propanamide(398470-86-5)

Safety Data

• Hazardous Substances Data: 398470-86-5(Hazardous Substances Data)

Upstream product

• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 19314-15-9 3-chloro-propionic acid p-phenetidide 

Relevant articles and documents

Synthesis, evaluation and molecular modelling studies of some novel 3-(3,4-dihydroisoquinolin-2(1H)-yl)-N-(substitutedphenyl)propanamides as HIV-1 non-nucleoside reverse transcriptase inhibitors

A novel series of fifteen 3-(3,4-dihydroisoquinolin-2(1H)-yl)-N- (substituted phenyl) propanamides 3(a-o) were synthesized by reacting the corresponding 3-chloro-N-(aryl) propanamides 2(a-o) with 1,2,3,4- tetrahydroisoquinoline 1 in acetonitrile. The compounds have been characterized on the basis of elemental analysis and spectral data. All the compounds were evaluated for their HIV-1 RT inhibitory activity. Among the synthesized compounds, 3-(3,4-dihydroisoquinolin-2(1H)-yl)-N-o-tolyl propanamide 3d and 3-(3,4-dihydroisoquinolin-2(1H)-yl)-N-(2,4,6-tribromophenyl)propanamide 3f were identified as significant inhibitors of HIV-1 reverse transcriptase with 56% and 43% residual RT activity respectively at the final concentration of 40 μM when compared with the standard drug Efavirenz. Docking studies with HIV-1 RT (PDB ID 1rt2) were also performed in order to investigate the binding pattern of these compounds. Indian Academy of Sciences.