39856-50-3

Basic information

• Product Name: 5-Bromo-2-nitropyridine
• Synonyms: 5-BROMO-2-NITROPYRIDINE;3-BROMO-6-NITROPYRIDINE;AKOS BBS-00001330;2-NITRO-5-BROMOPYRIDINE;2-NITRO-5-BROMO PYRIDINE(5-BROMO-2-NITROPYRIDINE);5-BROMO-2-NITROPYRIDINE, 98+%;3-Bromo-6-nitropyridine (5-Bromo-2-nitropyridine);5-Bromo-2-notropyridine
• CAS NO: 39856-50-3
• Molecular Formula: C₅H₃BrN₂O₂
• Molecular Weight: 202.99
• EINECS: 1592732-453-0
• Product Categories: blocks;Bromides;Pyridines;Pyridine;Pyridines, Pyrimidines, Purines and Pteredines;Pyridines derivates;Organohalides;Bromopyridines;Halopyridines;C5Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Heterocycle-Pyridine series
• Mol File: 39856-50-3.mol
• Article Data: 10

Chemical Properties

• Melting Point: 148-150 °C(lit.)
• Boiling Point: 292.3 °C at 760 mmHg
• Flash Point: 130.6 °C
• Appearance: /
• Density: 1.833 g/cm³
• Vapor Pressure: 0.00323mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: -4.95±0.22(Predicted)
• BRN: 120878
• CAS DataBase Reference: 5-Bromo-2-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-2-nitropyridine(39856-50-3)
• EPA Substance Registry System: 5-Bromo-2-nitropyridine(39856-50-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: III
• Hazardous Substances Data: 39856-50-3(Hazardous Substances Data)

Usage

Chemical Properties

Colorless solid

Uses

5-Bromo-2-nitropyridine is employed as a reagent in the synthesis of novel benzinidazoles, potent inhibitors of TIE-2 and VEGFR-2 Tyrosine (T899975) kinase receptors.

InChI:InChI=1/C5H3BrN2O2/c6-4-1-2-5(7-3-4)8(9)10/h1-3H

Upstream product

• 1072-97-5 5-bromo-2-pyridylamine 
• 30766-11-1 5-bromoisonicotinic acid 
• 504-29-0 2-aminopyridine 
• 626-55-1 3-Bromopyridine 
• 2402-97-3 3-bromopyridine N-oxide 

Downstream Products

• 13472-85-0 2-methoxy-5-bromopyridine 
• 55849-30-4 5-bromo-2-ethoxypyridine 
• 870521-31-6 5-bromo-2-isopropoxy-pyridine 
• 861025-69-6 2-nitro-5-(4-nitro-phenylsulfanyl)-pyridine 
• 77012-86-3 5-(4-chloro-phenylsulfanyl)-2-nitro-pyridine 
• 1072-97-5 5-bromo-2-pyridylamine 
• 14916-65-5 6-nitropyridin-3-ylamine 
• 492-97-7 2,2'-Bithiophene 
• 125889-39-6 5-vinyl-2-nitropyridine 
• 97608-11-2 2-nitro-5-phenylpyridine 
• 15009-91-3 2-nitropyridine 
• 13466-38-1 5-bromopyridin-2-ol 
• 766-11-0 5-bromo-2-fluoropyridine 
• 779345-38-9 2-nitro-5-phenoxypyridine 

Relevant articles and documents

Green preparation method of anti-cancer drug palbociclib intermediate

The invention belongs to the technical field of chemicals, and particularly relates to a green preparation method of an anti-cancer drug palbociclib intermediate. Zirconium nitrate and ammonium metatungstate are used as raw materials, a Zr/W composite oxide is prepared by adopting a homogeneous precipitation method, and an acidified tungsten/zirconium bimetallic oxide is prepared by sulfuric acid impregnation and is used for catalyzing hydrogen peroxide to oxidize 2-amino-5-bromopyridine to prepare 2-nitro-5-bromopyridine. The catalytic oxidation process is green and pollution-free, and waste acid cannot be generated; and the oxidation process is relatively mild, basically no 3, 5-dibromo-2-aminopyridine byproduct is generated in the oxidation process, and the purity and yield of the crude product are relatively high.

A Palumbo Xilin synthesis of intermediates method (by machine translation)

The present invention provides a Palumbo Xilin synthesis of intermediates method, and in particular relates to technical field of drug synthesis, the invention of the Palumbo vial is means intermediate 4 - (6 - aminopyridin - 3 - yl) piperazine - 1 - carboxylic acid tert-butyl, in order to 2 - amino - 5 - bromo pyridine as the starting material, through oxidation, coupling, reduction to obtain the target product of the process route, to the influence of factors experimental study of the system, compared with the conventional preparation process, the invention process route in the production cost, the operation of the technique, the product yield and purity and environmental protection there are obviously increased and improved. (by machine translation)

Preparation method of 2-nitro-5-bromopyridine

The invention relates to a preparation method of 2-nitro-5-bromopyridine. The 2-nitro-5-bromopyridine is adopted as a starting raw material, glacial acetic acid is adopted as a solvent, peracetic acid is adopted as an auxiliary material, and distillation, washing, alkali washing, filtering, drying and recrystallization are performed to obtain a target product. According to the method, the synthesis yield is high, the equipment corrosion is small, the safety is high, acetic acid can be recycled, the cost is saved, and little environmental pollution is caused.