39886-80-1Relevant articles and documents
New scalable and eco-friendly synthesis of gingerols
Vijendra Kumar,Srinivas,Bettadaiah
, p. 2993 - 2995 (2012/07/31)
Synthesis of 6-gingerol and its congeners 7- and 9-gingerols has been achieved from eugenol by a new scalable and eco-friendly protocol. The key steps are functionalization of eugenol to the nitro compound and its reaction under optimized condition with terminal alkenes to afford intermediate isoxazolines. The latter on catalytic hydrogenation in presence of Raney nickel afford corresponding gingerols in good yields.
CHIRAL LEWIS ACIDS FOR ENANTIOSELECTIVE C-C BOND FORMATION
Reetz, M. T.,Kunisch, F.,Heitmann, P.
, p. 4721 - 4724 (2007/10/02)
The optically active Lewis acid 6 has been prepared and used in the enantioselective addition of enolsilanes and Me3SiCN to aldehydes.
Asymmetric Synthesis of a β-Ketol Moiety via 3,5-Disubstitute Isoxazoles: Application to (+)-(S)--Gingerol
Giovanni, Baraldi Pier,Fabio, Moroder,Piero, Pollini Gian,Daniele, Simoni,Achille, Barco,Simonetta, Benetti
, p. 2983 - 2988 (2007/10/02)
A new synthesis of (+/-)--gingerol (13), (+)-(S)--gingerol, and (+)-methyl--gingerol (12c) using 3,5-disubstituted isoxazoles as masked β-ketols, is described.Reductive fission of the labile N-O bond of the isoxazoles (8a) and (8b) gave the enami