3989-48-8

Basic information

• Product Name: 1-(methylsulfonyl)piperidine
• Synonyms: 1-(Methylsulfonyl)piperidine; piperidine, 1-(methylsulfonyl)-
• CAS NO: 3989-48-8
• Molecular Formula: C₆H₁₃NO₂S
• Molecular Weight: 163.2379
• Mol File: 3989-48-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 256.4°C at 760 mmHg
• Flash Point: 108.8°C
• Density: 1.2g/cm³
• Vapor Pressure: 0.0155mmHg at 25°C
• Refractive Index: 1.507
• CAS DataBase Reference: 1-(methylsulfonyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(methylsulfonyl)piperidine(3989-48-8)
• EPA Substance Registry System: 1-(methylsulfonyl)piperidine(3989-48-8)

Safety Data

• Hazardous Substances Data: 3989-48-8(Hazardous Substances Data)

Usage

General Description

1-(methylsulfonyl)piperidine is a chemical compound with the molecular formula C6H13NO2S. It is a piperidine derivative that contains a methylsulfonyl group attached to the piperidine ring. 1-(methylsulfonyl)piperidine is used in organic synthesis as a building block for the production of various pharmaceuticals, agrochemicals, and synthetic intermediates. It has also been studied for its potential pharmacological effects, particularly in the field of medicinal chemistry. Additionally, 1-(methylsulfonyl)piperidine is known for its use as a reagent in chemical reactions, such as in the construction of complex organic molecules and in the preparation of certain functional groups.

Upstream product

• 110-89-4 piperidine 
• 124-63-0 methanesulfonyl chloride 
• 20277-69-4 sodium methansulfinate 

Downstream Products

• 1041376-75-3 1-phenyl-2-(piperidin-1-ylsulfonyl)ethan-1-one 
• 6091-44-7 piperidine hydrochloride 
• 4972-29-6 benzenesulphinyl chloride 

Relevant articles and documents

A straightforward synthesis of 5-sulfonamidomethyl substituted 4,7-dihydroazolo[1,5-a]pyrimidines

4,7-Dihydroazolo[1,5-a]pyrimidin-5-ylmethanesulfonamides are side-products of the three-component Biginelli-like reaction of aminoazoles, aldehydes and N,N-dialkyl-2-ketomethanesulfonamides. Herein, we report a straightforward synthesis of 5-sulfonamidomethyl substituted 4,7-dihydroazolo[1,5-a]pyrimidines by a two-component condensation of aminoazoles and N,N-dialkyl(cinnamoyl)methanesulfonamides in DMF at reflux. The starting N,N-dialkyl-2-ketomethanesulfonamides can be obtained by either lithiation of N,N-dialkylmethanesulfonamides and reaction with aldehydes followed by oxidation of the resulting alcohols or by Claisen condensation of N,N-dialkylmethanesulfonamides with the corresponding esters. The chemical structures of all synthesized compounds are supported by 1H and 13C NMR-spectroscopy, mass spectrometry and elemental analysis.

Highly enantioselective transfer hydrogenation of racemic α-substituted β-keto sulfonamides: Via dynamic kinetic resolution

Highly enantioselective transfer hydrogenation of β-keto sulfonamides was developed via dynamic kinetic resolution using a chiral Ru(ii) catalyst with an azeotropic solution of HCO2H/Et3N as a hydrogen donor, affording α-substituted β-hydroxyl sulfonamides in good yields with excellent diastereo- and enantioselectivities. This method is featured with mild conditions, easy operation, and a broad substrate scope, which make it possible to find wide applications in the synthesis of natural products and biologically active compounds containing the α-substituted β-hydroxyl sulfonamide core.

DBN hexafluorophosphate salts as convenient sulfonylating and phosphonylating agents

Air-stable N-sulfonyl and N-phosphonyl DBN hexafluorophosphate salts have been synthesised under mild conditions as sulfonylating and phosphonylating agents. These salts are highly efficient in the sulfonylation and phosphonylation of a range of N- and O-nucleophiles to generate sulfonamides, sulfonate esters, phosphoramidates and phosphonate esters in good yields.