399515-02-7

Basic information

• Product Name: Butanedioic acid, 2,3-bis[(4-methylbenzoyl)oxy]-, (2S,3S)-, compd. with 3-[(1S)-1-(dimethylamino)ethyl]phenyl ethylmethylcarbamate (1:1)
• CAS NO: 399515-02-7
• Molecular Formula: C20H18O8.C14H22N2O2
• Molecular Weight: 636.699
• Mol File: 399515-02-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Butanedioic acid, 2,3-bis[(4-methylbenzoyl)oxy]-, (2S,3S)-, compd. with 3-[(1S)-1-(dimethylamino)ethyl]phenyl ethylmethylcarbamate (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: Butanedioic acid, 2,3-bis[(4-methylbenzoyl)oxy]-, (2S,3S)-, compd. with 3-[(1S)-1-(dimethylamino)ethyl]phenyl ethylmethylcarbamate (1:1)(399515-02-7)
• EPA Substance Registry System: Butanedioic acid, 2,3-bis[(4-methylbenzoyl)oxy]-, (2S,3S)-, compd. with 3-[(1S)-1-(dimethylamino)ethyl]phenyl ethylmethylcarbamate (1:1)(399515-02-7)

Safety Data

• Hazardous Substances Data: 399515-02-7(Hazardous Substances Data)

Upstream product

• 32634-68-7 (2S,3S)-di-4-toluoyltartaric acid 
• 105601-20-5 rac-rivastigmine 

Downstream Products

• 123441-03-2 rivastigmin 

Relevant articles and documents

AN IMPROVED PROCESS FOR THE SEPARATION OF ENANTIOMERICALLY PURE COMPOUNDS

The present patent application relates to an improved process for the separation of enantiomerically pure compounds. Specifically it relates to separation of enantiomerically pure Rivastigmine, Duloxetine, Escitalopram and their intermediates in high yields.

AN EFFICIENT METHOD FOR PREPARATION OF (S)-3-[(1-DIMETHYL AMINO)ETHYL]-PHENYL-N-ETHYL-N-METHYL-CARBAMATE

The present invention relates to a method for preparation of substituted phenyl carbamate and pharmaceutically acceptable salts thereof, which are of current pharmaceutical interest. The substituted phenyl carbamate and pharmaceutically acceptable salts thereof are useful to raise cholinergic activity in the central nervous system and useful in treatment of diseases such as Alzheimer's disease, Down's syndrome, Huntingdon's chorea, Friedrich's ataxia etc. (S)-3-[(1-dimethyl amino)ethyl]- phenyl-N-ethyl-N-methyl-carbamate (I) is the active ingredient of the pharmaceutical composition referred in US 5,602,176. This compound is also used to induce selective inhibition of acetylcholinesterase activity in the brain.