39964-89-1Relevant articles and documents
Total synthesis of tropoloisoquinolines: Imerubrine, isoimerubrine, and grandirubrine
Lee, Jae Chol,Cha, Jin Kun
, p. 3243 - 3246 (2007/10/03)
A unified, ready access to the tropoloisoquinoline alkaloids imerubrine (1), grandirubrine (2), and isoimerubrine (3) is delineated and features sequential application of the intramolecular Diels - Alder reaction of an acetylene-tethered oxazole and the [
A SIMPLIFIED ISOQUINOLINE SYNTHESIS
Boger, Dale L.,Brotherton, Christine E.,Kelley, Marshall D.
, p. 3977 - 3980 (2007/10/02)
A simple variation of the Pomeranz-Fritsch cyclization provides a short, efficient route to isoquinolines.Treatment of benzylic halides or mesylates 1 with the sodium anion of N-tosyl aminoacetaldehyde dimethyl acetal (2) followed by acid-catalyzed cyclization provides an effective, two-step preparation of isoquinolines 4.