400899-07-2

Basic information

• Product Name: Cyclohexanecarboxylic acid, 4-[[(1,1-dimethylethoxy)carbonyl]methylamino]-, methyl ester, trans-
• CAS NO: 400899-07-2
• Molecular Formula: C14H25NO4
• Molecular Weight: 271.357
• Mol File: 400899-07-2.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Cyclohexanecarboxylic acid, 4-[[(1,1-dimethylethoxy)carbonyl]methylamino]-, methyl ester, trans-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanecarboxylic acid, 4-[[(1,1-dimethylethoxy)carbonyl]methylamino]-, methyl ester, trans-(400899-07-2)
• EPA Substance Registry System: Cyclohexanecarboxylic acid, 4-[[(1,1-dimethylethoxy)carbonyl]methylamino]-, methyl ester, trans-(400899-07-2)

Safety Data

• Hazardous Substances Data: 400899-07-2(Hazardous Substances Data)

Upstream product

• 62456-15-9 methyl trans-4-amino-cyclohexanecarboxylate 
• 61367-07-5 trans-4-aminocyclohexylcarboxylic acid methyl ester hydrochloride 
• 74-88-4 methyl iodide 
• 53292-90-3 trans-4-(tert-butoxycarbonylamino)cyclohexanoic acid 
• 146307-51-9 methyl (1R,4R)-4-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 150594-68-6 methyl (1r,4r)-4-(methylamino)cyclohexane-1-carboxylate 
• 400899-08-3 tert-butyl ((1r,4r)-4-(hydroxymethyl)cyclohexyl)(methyl)carbamate 
• 53292-90-3 trans-4-(tert-butoxycarbonylamino)cyclohexanoic acid 
• 400899-17-4 methanesulfonic acid 5-[4-(tert-butoxycarbonyl-methyl-amino)-cyclohexyl]-pentyl ester 
• 400899-16-3 [4-(5-hydroxy-pentyl)-cyclohexyl]-methyl-carbamic acid tert-butyl ester 
• 400899-10-7 3-[4-(tert-butoxycarbonyl-methyl-amino)-cyclohexyl]-propionic acid ethyl ester 
• 400899-11-8 [4-(3-hydroxy-propyl)-cyclohexyl]-methyl-carbamic acid tert-butyl ester 
• 400899-12-9 methyl-[4-(3-oxo-propyl)-cyclohexyl]-carbamic acid tert-butyl ester 
• 400898-94-4 trans-(4-formylcyclohexyl)methylcarbamic acid tert-butyl ester 

Relevant articles and documents

Oxidosqualene cyclase (OSC) inhibitors for the treatment of dyslipidemia

Novel inhibitors of oxidosqualene cyclase (OSC) for the treatment of dyslipidemia are reported. Starting point for the chemistry program was a set of compounds derived from a fungicide project which, in addition to high affinity for OSC from Candida albicans, also showed high affinity for the human enzyme (hOSC). Here the evaluation process of different scaffolds is outlined for two representative series, the phenyl substituted benzo[d]isothiazoles and the aminocyclohexanes. The most promising compounds derived from the latter series were further profiled in vivo and showed promising properties with respect to modulation of lipid parameters. Schweizerische Chemische Gesellschaft.

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

BIFUNCTIONAL DEGRADERS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND THERAPEUTIC USE THEREOF

The present disclosure provides bifunctional compounds as IRAK4 degraders via ubiquitin proteasome pathway, and method for treating diseases modulated by IRAK4.