40114-49-6

Basic information

• Product Name: 1-Benzyl-3-piperidone
• Synonyms: 1-(PHENYLMETHYL)-3-PIPERIDONE HCL H2O;1-BENZYLPIPERIDIN-3-ONE;1-BENZYL-3-PIPERIDINONE;1-BENZYL-3-PIPERIDONE;1-BENZYL-3-PIPERIDONE HCL H2O;1-BENZYL-3-PIPERIDONE HCL HYDRATE;1-BENZYL-3-PIPERIDONE HYDRATE HYDROCHLORIDE;1-BENZYL-3-PIPERIDONE HYDROCHLORIDE HYDRATE
• CAS NO: 40114-49-6
• Molecular Formula: C₁₂H₁₅NO
• Molecular Weight: 189.25
• EINECS: 256-646-0
• Product Categories: pharmacetical;Heterocycles series;Piperidine;Piperidines
• Mol File: 40114-49-6.mol
• Article Data: 16

Chemical Properties

• Melting Point: 170-176 °C
• Boiling Point: 295 °C
• Flash Point: 123 °C
• Appearance: /
• Density: 1.098
• Vapor Pressure: 0.00161mmHg at 25°C
• Storage Temp.: 2-8°C
• PKA: 6.10±0.20(Predicted)
• CAS DataBase Reference: 1-Benzyl-3-piperidone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl-3-piperidone(40114-49-6)
• EPA Substance Registry System: 1-Benzyl-3-piperidone(40114-49-6)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 36/37/38-22
• Safety Statements: 22-24/25
• WGK Germany: 3
• F: 10
• HazardClass: IRRITANT
• Hazardous Substances Data: 40114-49-6(Hazardous Substances Data)

Usage

General Description

1-Benzyl-3-piperidone, also known as BZP, is a chemical compound with a molecular formula of C14H17NO. It is a synthetic stimulant that acts as a designer drug and is known for its psychoactive effects. BZP is chemically similar to amphetamines and can cause a range of effects, including increased alertness, euphoria, and heightened energy levels. However, its use is associated with a number of potential risks and adverse effects, including hypertension, hyperthermia, and serotonin syndrome. BZP is often found in party pills and other recreational drugs, and its use is prohibited in many countries due to its potential for abuse and harm.

InChI:InChI=1/C12H15NO.ClH.H2O/c14-12-7-4-8-13(10-12)9-11-5-2-1-3-6-11;;/h1-3,5-6H,4,7-10H2;1H;1H2

Upstream product

• 14813-01-5 1-benzyl-3-hydroxypiperidine 
• 6859-99-0 3-hydroxypiperazine 
• 100-44-7 benzyl chloride 
• 445-01-2 5-bromo-2-chlorobenzotrifluoride 
• 109-00-2 3-HYDROXYPYRIDINE 
• 100-39-0 benzyl bromide 
• 62214-78-2 1-benzyl-3-hydroxypyridin-1-ium bromide 
• 50606-58-1 N-benzyl-3-piperidinone hydrochloride 
• 63876-32-4 4-[benzyl(ethoxycarbonylmethyl)amino]butyric acid ethyl ester 
• 105973-51-1 N-benzyl-3-hydroxypiperidine hydrochloride 
• 61995-16-2 1-Benzyl-3,3-dihydroxypiperidine hydrobromide 
• 39514-19-7 ethyl 1-benzyl-3-oxo-4-piperidinecarboxylate 

Downstream Products

• 58879-07-5 N-benzyl-3-hydroxy-3-phenylpiperidine 
• 857385-77-4 3-(4-ethoxy-phenyl)-1-benzyl-piperidin-3-ol 
• 127364-04-9 1-Benzyl-3,3-(ethylenedioxy)piperidine 
• 54596-15-5 1-benzyl-3-[2-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-phenyl]-piperidin-3-ol 
• 170161-34-9 1-benzyl-1,2,5,6-tetrahydropyridin-3-yl trifluoromethanesulfonate 
• 112197-76-9 1-benzyl-3-((trimethylsilyl)oxy)piperidine-3-carbonitrile 
• 155137-17-0 N-benzyl-3-methylenepiperidine 
• 61832-59-5 N-benzyl-3-(3',4'-dibenzyloxyphenyl)-3-hydroxy-piperidine 
• 150018-99-8 1-benzyl-3-hydroxypiperidine-3-carbonitrile 
• 58879-07-5 1-benzyl-3-phenyl-3-piperidinol 
• 97267-35-1 5-benzyl-1-oxa-5-aza-spiro[2.5]octane 
• 61995-20-8 N-(benzyloxycarbonyl)-3-piperidone 
• 178385-88-1 3-(1-benzyl-1,2,5,6-tetrahydropyridin-3-yl)-1H-indole 
• 181184-17-8 5,6-dimethoxy-3-(1-benzyl-1,2,5,6-tetrahydropyridin-3-yl)-1H-indole 

Relevant articles and documents

Preparation method N-substituted piperidine -3- ketone (by machine translation)

The invention provides N -substituted piperi- 3 3-ketone preparation method, which uses acrylonitrile (II) and nitromethane as raw materials to obtain 4 -substituted-N-alkoxycarbonylmethyl- 4 4-aminobutyronitrile (III), to obtain 4 - substituent - N N-alkoxycarbonylmethyl( (IV),substituted-piperi- 3 3-one N - by addition reaction and decarboxylation to yield (V),substituted-piperidin-3-one according. to the present invention by two-time substituent reaction, reaction, and decarboxylation to obtain, a compound obtained from, N -substituted-piperidin-3-one of, the invention. (I). The method is simple, process and, times of reaction and decarboxylation. (by machine translation)

A N - Boc - 3 - piperidone preparation method (by machine translation)

The invention discloses a N - Boc - 3 - piperidone preparation method, which belongs to the technical field of organic synthesis. N - benzyl - 3 - hydroxy pyridine quaternary ammonium salt in the presence of a Lewis acid with potassium borohydride reduction reaction to obtain N - benzyl - 3 - piperidone; then after catalytic hydrogenation conditions with palladium of di-T-n-butyl reaction to obtain N - Boc - 3 - piperidone. Compared with the prior synthetic method, the invention one-step reaction will be N - benzyl - 3 - hydroxy pyridine quaternary ammonium salt selective reduction to obtain N - benzyl - 3 - piperidone, the reaction is fast, convenient separation of products, less side reaction, the advantages of synthetic route is simple. (by machine translation)

Iridium-catalyzed selective hydrogenation of 3-hydroxypyridinium salts: A facile synthesis of piperidin-3-ones

The selective hydrogenation of 3-hydroxypyridinium salts has been achieved using a homogeneous iridium catalyst, providing a direct access to 2- and 4-substituted piperidin-3-one derivatives with high yields, which are important organic synthetic intermediates and the prevalent structural motifs in pharmaceutical agents. Mild reaction conditions, high chemoselectivity, and easy scalability make this reaction highly practical for the synthesis of piperidin-3-ones.