402-26-6

Basic information

• Product Name: 3-TRIFLUOROMETHYLPHENYL MAGNESIUM BROMIDE
• CAS NO: 402-26-6
• Molecular Formula: C7H4BrF3Mg
• Molecular Weight: 249.313
• Mol File: 402-26-6.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 3-TRIFLUOROMETHYLPHENYL MAGNESIUM BROMIDE (CAS DataBase Reference)
• NIST Chemistry Reference: 3-TRIFLUOROMETHYLPHENYL MAGNESIUM BROMIDE (402-26-6)
• EPA Substance Registry System: 3-TRIFLUOROMETHYLPHENYL MAGNESIUM BROMIDE (402-26-6)

Safety Data

• Safety Statements: Solutions in org solvs (e.g., ether, benzene) may explode above 40°C. When heated to decomposition it emits toxic fumes of Fsup xmlns="">−/sup> and Brsup xmlns="">−/sup>. See also a target="_blank" href="lom/card_sa.tes?href=content/sax0004/sdp03880.xml&view=print">BROMIDES/a>, a target="_blank" href="lom/card_sa.tes?href=content/sax0016/sdp15863.xml&view=print">MAGNESIUM COMPOUNDS/a>, and a target="_blank" href="lom/card_sa.tes?href=content/sax0013/sdp12465.xml&view=print">FLUORIDES/a>.
• HazardClass: 3
• Hazardous Substances Data: 402-26-6(Hazardous Substances Data)

Upstream product

• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 7439-95-4 magnesium 

Downstream Products

• 455-01-6 2-[3-(trifluoromethyl)phenyl]ethanol 
• 395-09-5 2-[1-(3-trifluoromethyl-phenyl)-vinyl]-thiophene 
• 742-91-6 diphenyl(3-(trifluoromethyl)phenyl)methanol 
• 402-33-5 dichloromethylsilane 
• 565-10-6 me(ph-3-CF₃)2SiCl 
• 585-35-3 1-deuterio-3-trifluoromethyl-benzene 
• 779-70-4 dichloro-(3-trifluoromethyl-phenyl)-vinyl-silane 
• 401-36-5 4-diethylamino-1-(3-trifluoromethyl-phenyl)-butan-1-one 
• 349-75-7 3-(trifluoromethyl)benzyl alcohol 
• 454-92-2 3-(trifluoromethyl)benzoic acid 
• 565-11-7 (ph-3-CF₃)2SiCl₂ 
• 427-34-9 tri-(3-trifluoromethylphenyl)-fluorosilane 
• 379-45-3 (ph-3-CF₃)SiCl 
• 402-34-6 (ph-3-CF₃)SiCl₃ 

Relevant articles and documents

Iron-Catalyzed Cross-Coupling of Alkynyl and Styrenyl Chlorides with Alkyl Grignard Reagents in Batch and Flow

Transition-metal-catalyzed cross-coupling chemistry can be regarded as one of the most powerful protocols to construct carbon–carbon bonds. While the field is still dominated by palladium catalysis, there is an increasing interest to develop protocols that utilize cheaper and more sustainable metal sources. Herein, we report a selective, practical, and fast iron-based cross-coupling reaction that enables the formation of Csp?Csp3 and Csp2?Csp3 bonds. In a telescoped flow process, the reaction can be combined with the Grignard reagent synthesis. Moreover, flow allows the use of a supporting ligand to be avoided without eroding the reaction selectivity.

PYRIMIDONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE

The present invention relates to a compound having the general formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease, in particular influenza.

SULFONIUM SALT AND PHOTO-ACID GENERATOR

Provided is a novel sulfonium salt that has high solubility in a solvent and has high light sensitivity to, especially, light having a wavelength not longer than deep-UV (254 nm) and a novel photo-acid generator comprising the sulfonium salt. The invention relates to a sulfonium salt represented by the following general formula (1) and a novel photo-acid generator comprising the sulfonium salt. wherein R1 represents an electron withdrawing group; R2 and R3 each independently represent an alkyl group having 1 to 5 carbon atoms, an alkoxy group, an acyl group, a halogenated alkyl group, a halogen atom, a hydroxyl group, a cyano group, or a nitro group; p and q each independently represent an integer of 0 to 5; and X? represents a monovalent counter anion.