Welcome to LookChem.com Sign In|Join Free

Cas Database

402-52-8

402-52-8

Identification

  • Product Name:Benzene,1-methoxy-4-(trifluoromethyl)-

  • CAS Number: 402-52-8

  • EINECS:

  • Molecular Weight:176.138

  • Molecular Formula: C8H7F3O

  • HS Code:2909309090

  • Mol File:402-52-8.mol

Synonyms:Anisole,p-(trifluoromethyl)- (7CI,8CI);4-Methoxy-1-(trifluoromethyl)benzene;4-Methoxybenzotrifluoride;Methylp-trifluoromethylphenyl ether;p-(Trifluoromethyl)anisole;p-Methoxy(trifluoromethyl)benzene;

Post Buying Request Now
Entrust LookChem procurement to find high-quality suppliers faster

Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi

  • Signal Word:Danger

  • Hazard Statement:H225 Highly flammable liquid and vapour

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:4-(Trifluoromethyl)anisole
  • Packaging:5g
  • Price:$ 220
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-(Trifluoromethyl)anisole 98%
  • Packaging:100 g
  • Price:$ 325
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-(Trifluoromethyl)anisole 98%
  • Packaging:25 g
  • Price:$ 125
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-(Trifluoromethyl)anisole 98%
  • Packaging:1 g
  • Price:$ 15
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-(Trifluoromethyl)anisole 98%
  • Packaging:5 g
  • Price:$ 45
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Crysdot
  • Product Description:1-Methoxy-4-(trifluoromethyl)benzene 95+%
  • Packaging:5g
  • Price:$ 50
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Crysdot
  • Product Description:1-Methoxy-4-(trifluoromethyl)benzene 95+%
  • Packaging:25g
  • Price:$ 140
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Crysdot
  • Product Description:1-Methoxy-4-(trifluoromethyl)benzene 95+%
  • Packaging:10g
  • Price:$ 75
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Chemenu
  • Product Description:1-Methoxy-4-(trifluoromethyl)benzene 95%
  • Packaging:25g
  • Price:$ 143
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Arctom
  • Product Description:4-Methoxybenzotrifluoride ≥98%
  • Packaging:500g
  • Price:$ 725
  • Delivery:In stock
  • Buy Now

Relevant articles and documentsAll total 95 Articles be found

NOVEL METHOD FOR PRODUCING PERFLUOROALKYLATING AGENTS USING MONOHYDROPERFLUOROALKANE AS STARTING MATERIAL, AND METHOD FOR PRODUCING AROMATIC PERFLUOROALKYL COMPOUND USING THE SAME

-

Paragraph 0138-0139; 0141-0143, (2021/04/09)

PROBLEM TO BE SOLVED: To provide a simple method for producing trifluoromethyltriol borate potassium from trifluoromethane. SOLUTION: There is provided a method for producing a compound represented by the formula [7], comprising: reacting a monohydroperfluoroalkane with a base and trialkyl borate in an organic solvent; and then reacting the reaction solution with triol. [In the formula, RF is an alkyl group such as a linear chain of C1-2, and a perfluoroalkyl group in which all H on C is substituted with F; R6 is H or a C1-2 linear alkyl group, or the like; M may be a metal or the like belonging to Group I, Group II, Group III, Group IV, Group V, Group VI, Group VII, Group VIII, Group IX, Group X, Group XI, Group XII, and Group XIII in the periodic table of elements, and they may be a single substance or a mixture of a plurality of substances and y corresponds to the oxidation number of the substance represented by M.] SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

NOVEL METHOD FOR PRODUCING PERFLUOROALKYLATING AGENTS USING MONOHYDROPERFLUOROALKANE AS STARTING MATERIAL, AND METHOD FOR PRODUCING AROMATIC PERFLUOROALKYL COMPOUND USING THE SAME

-

Paragraph 0138-0139; 0141-0143, (2021/04/09)

PROBLEM TO BE SOLVED: To provide a method for producing an aromatic perfluoroalkyl compound using silylated trifluoromethyl carbinol. SOLUTION: There is provided a method for producing an aromatic perfluoroalkyl compound represented by the general formula [10], in which a compound represented by the formula [9] and a compound represented by the formula [1] are reacted in an organic solvent in the presence of a copper catalyst, a nitrogen ligand and a metal fluoride. R7-X...[9], RF-R7...[10] [In the formula, R7 is an aryl group or the like which may have a substituent; X is F, Cl, Br or I; RF is an alkyl group such as a linear chain of C1-2, and a perfluoroalkyl group in which all H on C is substituted with F; R1 and R2 are each independently H or a C1-2 linear alkyl group, or the like; R1 and R2 may be integrated to form a ring; and R3, R4 and R5 are each independently H or a C1-2 linear alkyl group, or the like.] SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

NOVEL METHOD FOR PRODUCING PERFLUOROALKYLATING AGENTS USING MONOHYDROPERFLUOROALKANE AS STARTING MATERIAL, AND METHOD FOR PRODUCING AROMATIC PERFLUOROALKYL COMPOUNDS USING THE SAME

-

Paragraph 0138-0143, (2021/04/02)

To provide a simple method for producing silylated trifluoromethylcarbinol from trifluoromethane.SOLUTION: There is provided a method for producing a compound represented by the formula [1], in which the compound is obtained by reacting a monohydroperfluoroalkane, a carbonyl compound, and NaH in an organic solvent and then reacting the reaction solution with a silylating agent. [In the formula, RF is an alkyl group such as a linear chain of C1 to 2, and a perfluoroalkyl group in which all H on C is substituted with F; R1 and R2 are independently alkyl groups such as a linear chain of H or C1 to 2, or the like respectively; R1 and R2 may be integrated to form a ring; and R3, R4 and R5 are independently H or C1 to 2 linear alkyl groups, or the like respectively.]SELECTED DRAWING: None

Mechanistic Insight into Copper-Mediated Trifluoromethylation of Aryl Halides: The Role of CuI

Liu, He,Wu, Jian,Jin, Yuxuan,Leng, Xuebing,Shen, Qilong

, p. 14367 - 14378 (2021/09/13)

The synthesis, characterization, and reactivity of key intermediates [Cu(CF3)(X)]-Q+ (X = CF3 or I, Q = PPh4) in copper-mediated trifluoromethylation of aryl halides were studied. Qualitative and quantitative studies showed [Cu(CF3)2]-Q+ and [Cu(CF3)(I)]-Q+ were not highly reactive. Instead, a much more reactive species, ligandless [CuCF3] or DMF-ligated species [(DMF)CuCF3], was generated in the presence of excess CuI. On the basis of these results, a general mechanistic map for CuI-promoted trifluoromethylation of aryl halides was proposed. Furthermore, on the basis of this mechanistic understanding, a HOAc-promoted protocol for trifluoromethylation of aryl halides with [Ph4P]+[Cu(CF3)2]- was developed.

Solvated Nickel Complexes as Stoichiometric and Catalytic Perfluoroalkylation Agents**

Shreiber, Scott T.,Vicic, David A.

supporting information, p. 18162 - 18167 (2021/07/14)

The acetonitrile-solvated [(MeCN)Ni(C2F5)3]? was prepared in order to compare and contrast its reactivity with the known [(MeCN)Ni(CF3)3]? towards organic electrophiles. Both [(MeCN)Ni(CF3)3]? and [(MeCN)Ni(C2F5)3]? successfully react with aryl iodonium and diazonium salts as well as alkynyl iodonium salts to give fluoroalkylated organic products. Electrochemical analysis of [(MeCN)NiII(C2F5)3]? suggests that, upon electro-oxidation to [(MeCN)nNiIII(C2F5)3], reductive homolysis of a perfluoroethyl radical occurs, with the concomitant formation of [(MeCN)2NiII(C2F5)2]. Catalytic C?H trifluoromethylations of electron-rich arenes were successfully achieved using either [(MeCN)Ni(CF3)3]? or the related [Ni(CF3)4]2?. Stoichiometric reactions of the solvated nickel complexes reveal that “ligandless” nickel is exceptionally capable of serving as reservoir of CF3 groups under catalytically relevant conditions.

Process route upstream and downstream products

Process route

trifluoromethylcopper(I)
77152-08-0

trifluoromethylcopper(I)

4-methoxy-aniline
104-94-9

4-methoxy-aniline

4-chloromethoxybenzene
623-12-1

4-chloromethoxybenzene

para-methoxynitrobenzene
100-17-4

para-methoxynitrobenzene

methyl 4-(trifluoromethyl)phenyl ether
402-52-8

methyl 4-(trifluoromethyl)phenyl ether

Conditions
Conditions Yield
4-methoxy-aniline; With hydrogenchloride; tert.-butylnitrite; In 1,4-dioxane; acetonitrile; at 0 ℃; Inert atmosphere;
trifluoromethylcopper(I); In 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile; at 0 ℃; Overall yield = 30 %Spectr.; Inert atmosphere;
1-bromo-4-methoxy-benzene
104-92-7

1-bromo-4-methoxy-benzene

trifluoroacetic acid-methyl ester
431-47-0

trifluoroacetic acid-methyl ester

para-iodoanisole
696-62-8

para-iodoanisole

methyl 4-(trifluoromethyl)phenyl ether
402-52-8

methyl 4-(trifluoromethyl)phenyl ether

Conditions
Conditions Yield
With cesium fluoride; copper(l) iodide; In N,N-dimethyl-formamide; at 180 ℃; for 8h;
7 % Chromat.
trifluoroacetic acid-methyl ester
431-47-0

trifluoroacetic acid-methyl ester

para-iodoanisole
696-62-8

para-iodoanisole

4-chloromethoxybenzene
623-12-1

4-chloromethoxybenzene

methyl 4-(trifluoromethyl)phenyl ether
402-52-8

methyl 4-(trifluoromethyl)phenyl ether

Conditions
Conditions Yield
With cesium chloride; copper(l) iodide; In N,N-dimethyl-formamide; at 180 ℃; for 4h;
60 % Spectr.
12 % Chromat.
trifluoromethylcopper(I)
77152-08-0

trifluoromethylcopper(I)

4-methoxy-aniline
104-94-9

4-methoxy-aniline

4-chloromethoxybenzene
623-12-1

4-chloromethoxybenzene

methyl 4-(trifluoromethyl)phenyl ether
402-52-8

methyl 4-(trifluoromethyl)phenyl ether

Conditions
Conditions Yield
4-methoxy-aniline; With hydrogenchloride; tert.-butylnitrite; In 1,4-dioxane; acetonitrile; at 0 - 20 ℃; Inert atmosphere;
trifluoromethylcopper(I); In 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile; at 0 ℃; Overall yield = 55 %Spectr.; Inert atmosphere;
Bromotrifluoromethane
75-63-8

Bromotrifluoromethane

methoxybenzene
100-66-3

methoxybenzene

methyl 4-(trifluoromethyl)phenyl ether
402-52-8

methyl 4-(trifluoromethyl)phenyl ether

3-(trifluoromethyl)anisole
454-90-0

3-(trifluoromethyl)anisole

1-methoxy-2-(trifluoromethyl)benzene
395-48-2

1-methoxy-2-(trifluoromethyl)benzene

Conditions
Conditions Yield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium diacetate; caesium carbonate; catacxium A; In acetone; at 130 ℃; for 40h; Overall yield = 53 %Spectr.; regioselective reaction; Inert atmosphere; Autoclave;
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; di(1-adamantyl)-n-butylphosphine; palladium diacetate; In acetone; at 130 ℃; for 40h; under 2250.23 - 11251.1 Torr; Overall yield = 70 %; Autoclave; Inert atmosphere;
iodotrifluoromethane
2314-97-8,263005-66-9

iodotrifluoromethane

methoxybenzene
100-66-3

methoxybenzene

methyl 4-(trifluoromethyl)phenyl ether
402-52-8

methyl 4-(trifluoromethyl)phenyl ether

3-(trifluoromethyl)anisole
454-90-0

3-(trifluoromethyl)anisole

1-methoxy-2-(trifluoromethyl)benzene
395-48-2

1-methoxy-2-(trifluoromethyl)benzene

Conditions
Conditions Yield
With sulfuric acid; dihydrogen peroxide; iron(II) sulfate; In water; dimethyl sulfoxide; at 45 ℃; for 0.333333h;
(trifluoromethyl)trimethylsilane
81290-20-2

(trifluoromethyl)trimethylsilane

methoxybenzene
100-66-3

methoxybenzene

methyl 4-(trifluoromethyl)phenyl ether
402-52-8

methyl 4-(trifluoromethyl)phenyl ether

3-(trifluoromethyl)anisole
454-90-0

3-(trifluoromethyl)anisole

1-methoxy-2-(trifluoromethyl)benzene
395-48-2

1-methoxy-2-(trifluoromethyl)benzene

Conditions
Conditions Yield
With potassium fluoride; silver trifluoromethanesulfonate; In 1,2-dichloro-ethane; at 85 ℃; for 24h; Inert atmosphere; Darkness;
trifluoromethane sulfonyl chloride
421-83-0

trifluoromethane sulfonyl chloride

methoxybenzene
100-66-3

methoxybenzene

methyl 4-(trifluoromethyl)phenyl ether
402-52-8

methyl 4-(trifluoromethyl)phenyl ether

3-(trifluoromethyl)anisole
454-90-0

3-(trifluoromethyl)anisole

1-methoxy-2-(trifluoromethyl)benzene
395-48-2

1-methoxy-2-(trifluoromethyl)benzene

Conditions
Conditions Yield
dichlorotris(triphenylphosphine)ruthenium(II); at 120 ℃; for 18h; Yield given. Yields of byproduct given;
With dichlorotris(triphenylphosphine)ruthenium(II); In pentane; at 120 ℃; for 18h; Yield given. Yields of byproduct given;
With N,N,N,N-tetraethylammonium tetrafluoroborate; triethylamine; In acetonitrile; Overall yield = 67 percentSpectr.; Electrochemical reaction;
Langlois reagent
2926-29-6

Langlois reagent

methoxybenzene
100-66-3

methoxybenzene

methyl 4-(trifluoromethyl)phenyl ether
402-52-8

methyl 4-(trifluoromethyl)phenyl ether

3-(trifluoromethyl)anisole
454-90-0

3-(trifluoromethyl)anisole

1-methoxy-2-(trifluoromethyl)benzene
395-48-2

1-methoxy-2-(trifluoromethyl)benzene

Conditions
Conditions Yield
With oxygen; In water; acetonitrile; at 120 ℃; for 23h; under 760.051 Torr; Overall yield = 61 %Chromat.;
bis(trifluoroacetyl)peroxide
383-73-3

bis(trifluoroacetyl)peroxide

methoxybenzene
100-66-3

methoxybenzene

methyl 4-(trifluoromethyl)phenyl ether
402-52-8

methyl 4-(trifluoromethyl)phenyl ether

3-(trifluoromethyl)anisole
454-90-0

3-(trifluoromethyl)anisole

1-methoxy-2-(trifluoromethyl)benzene
395-48-2

1-methoxy-2-(trifluoromethyl)benzene

Conditions
Conditions Yield
In 1,1,2-Trichloro-1,2,2-trifluoroethane; at 70 ℃; Yields of byproduct given;
In 1,1,2-Trichloro-1,2,2-trifluoroethane; at 70 ℃; Yield given. Yields of byproduct given;

Global suppliers and manufacturers

Global( 59) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • Amadis Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-571-89925085
  • Emails:sales@amadischem.com
  • Main Products:29
  • Country:China (Mainland)
  • Shaanxi BLOOM TECH Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-29-86470566
  • Emails:sales@bloomtechz.com
  • Main Products:80
  • Country:China (Mainland)
  • Shanghai Upbio Tech Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-21-52196435
  • Emails:upbiocn@hotmail.com
  • Main Products:88
  • Country:China (Mainland)
  • SAGECHEM LIMITED
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-571-86818502
  • Emails:will@sagechem.com
  • Main Products:28
  • Country:China (Mainland)
  • Win-Win chemical Co.Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:0086-577-64498589
  • Emails:sales@win-winchemical.com
  • Main Products:55
  • Country:China (Mainland)
  • Kono Chem Co.,Ltd
  • Business Type:Other
  • Contact Tel:86-29-86107037-8015
  • Emails:info@konochemical.com
  • Main Products:83
  • Country:China (Mainland)
  • Hangzhou Dingyan Chem Co., Ltd
  • Business Type:Manufacturers
  • Contact Tel:86-571-86465881,86-571-87157530,86-571-88025800
  • Emails:sales@dingyanchem.com
  • Main Products:95
  • Country:China (Mainland)
  • GIHI CHEMICALS CO.,LIMITED
  • Business Type:Lab/Research institutions
  • Contact Tel:571-86217390
  • Emails:info@gihichem.com
  • Main Products:66
  • Country:China (Mainland)
close
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 402-52-8
Post Buying Request Now
close
Remarks: The blank with*must be completed