40273-47-0

Basic information

• Product Name: 3-FLUOROISONICOTINALDEHYDE
• Synonyms: 3-FLUORO-4-FORMYLPYRIDINE;3-FLUOROPYRIDINE-4-CARBOXALDEHYDE;3-FLUOROISONICOTINALDEHYDE;4-Pyridinecarboxaldehyde,3-fluoro-(9CI);3-Fluoro-4-pyridinecarboxaldehyde;3-FLUORO-PYRIDINE-4-CARBALDEHYDE;3-FLUOROISONICOTINAL;3-Fluoro-4-pyridinecarbaldehyde
• CAS NO: 40273-47-0
• Molecular Formula: C₆H₄FNO
• Molecular Weight: 125.1
• EINECS: 1533716-785-6
• Product Categories: PYRIDINE;blocks;FluoroCompounds;Pyridines;pharmacetical;Building Blocks;Fluorinated;C6;Heterocyclic Building Blocks;NULL
• Mol File: 40273-47-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 70 °C25 mm Hg(lit.)
• Flash Point: 153 °F
• Appearance: /
• Density: 1.2550 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.531mmHg at 25°C
• Refractive Index: n20/D 1.5170(lit.)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 0.84±0.18(Predicted)
• CAS DataBase Reference: 3-FLUOROISONICOTINALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUOROISONICOTINALDEHYDE(40273-47-0)
• EPA Substance Registry System: 3-FLUOROISONICOTINALDEHYDE(40273-47-0)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38-43
• Safety Statements: 26-36/37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 40273-47-0(Hazardous Substances Data)

Usage

Chemical Properties

yellow liquid

InChI:InChI=1/C6H4FNO/c7-6-3-8-2-1-5(6)4-9/h1-4H

Upstream product

• 372-47-4 3-Fluoropyridine 
• 68-12-2 N,N-dimethyl-formamide 
• 107-31-3 Methyl formate 
• 177600-62-3 C₁₃H₁₀FN 
• 3430-27-1 3-amino-4-methylpyridine 
• 399-88-2 3-fluoro-4-methylpyridine 
• 695-34-1 2-Amino-4-methylpyridine 
• 109-94-4 formic acid ethyl ester 

Downstream Products

• 870243-58-6 methyl thieno[2,3-c]pyridine-2-carboxylate 
• 1259287-72-3 methyl 4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxylate 
• 1259287-87-0 C₁₄H₁₉NO₃S 
• 1259286-35-5 6-(cyclohexylcarbonyl)-N-hydroxy-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxamide 
• 721926-88-1 methyl 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxylate 
• 1426389-09-4 4-(2-(4-(3-fluoropyridin-4-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)thiazol-4-yl)benzonitrile 
• 478148-99-1 ethyl thieno[2,3-c]pyridine-2-carboxylate 
• 165947-51-3 6-(tert-butoxycarbonyl)-4,5,6,7-tetrahydrothieno [2,3-c]pyridine-2-carboxylic acid 

Relevant articles and documents

Synthesis of some fluorine-containing pyridinealdoximes of potential use for the treatment of organophosphorus nerve-agent poisoning

Fluoroheterocyclic aldoximes were screened as therapeutic agents for the treatment of anticholinesterase poisoning. 2-Fluoropyridine-3- and -6-aldoxime, and 3-fluoropyridine-2- and -4-aldoxime, were synthesised. Attempts to obtain 3,5,6-trifluoropyridine-2,4-bis(aldoxime) and -2-aldoxime, however, proved unsuccessful. Pentafluorobenzaldoxime was prepared by oximation of pentafluorobenzaldehyde. Acid dissociation constants (pKa) and second-order rate constants (kox-) of the fluorinated pyridinealdoximes towards sarin were measured. 2,3,5,6-Tetrafluoropyridine-4- aldoxime had the best profile: its kox- approached that of the therapeutic oxime P2S (310 vs. 120 l mol-1 min-1), but its higher pKa (9.1 vs. 7.8) fell short of the target figure of 8 required for reactivation of inhibited acetylcholinesterase in vivo. N-alkylation of the fluorinated pyridine-aldoximes may reduce their pK a nearer to 8 and enhance their therapeutic potential. Crown Copyright

PROCESS FOR MAKING SUBSTITUTED PIPERIDINES

The present invention provides a process for the preparation of substituted piperidines which comprises an asymmetric hydrogenation of vinyl fluoride in the presence of a metal precursor complexed with a chiral mono- or biphosphine ligand.

SUBSTITUTED VINYL PYRIDINE DERIVATIVE AND DRUGS CONTAINING THE SAME

The present invention relates to a substituted vinylpyridine derivative represented by the following formula (1): (wherein R1 represents a hydrogen atom, an alkyl group, etc., R2 represents an alkyl group; one of R3 and R4, which are different from each o