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Cas Database

40283-46-3

40283-46-3

Identification

  • Product Name:5-Thiazolecarboxylicacid, 2-amino-

  • CAS Number: 40283-46-3

  • EINECS:

  • Molecular Weight:144.154

  • Molecular Formula: C4H4N2O2S

  • HS Code:

  • Mol File:40283-46-3.mol

Synonyms:2-Amino-5-thiazolecarboxylicacid;NSC 239729;

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Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi

  • Signal Word:Warning

  • Hazard Statement:H317 May cause an allergic skin reaction

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:2-Aminothiazole-5-carboxylicAcid
  • Packaging:100mg
  • Price:$ 60
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:2-Aminothiazole-5-carboxylic acid 98%
  • Packaging:1g
  • Price:$ 25
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:2-Aminothiazole-5-carboxylic acid 98%
  • Packaging:5g
  • Price:$ 50
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:2-Aminothiazole-5-carboxylic acid 98%
  • Packaging:25g
  • Price:$ 98
  • Delivery:In stock
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  • Manufacture/Brand:Labseeker
  • Product Description:2-Amino-1,3-thiazole-5-carboxylicAcid 95
  • Packaging:1kg
  • Price:$ 1170
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:2-Aminothiazole-5-carboxylicacid 95%
  • Packaging:25g
  • Price:$ 85
  • Delivery:In stock
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  • Manufacture/Brand:Chemenu
  • Product Description:2-aminothiazole-5-carboxylicacid 95%
  • Packaging:500g
  • Price:$ 456
  • Delivery:In stock
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  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:2-Aminothiazole-5-carboxylic acid
  • Packaging:25 g
  • Price:$ 187.5
  • Delivery:In stock
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  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:2-Aminothiazole-5-carboxylic acid
  • Packaging:50 g
  • Price:$ 300
  • Delivery:In stock
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  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:2-Aminothiazole-5-carboxylic acid
  • Packaging:100 g
  • Price:$ 480
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Relevant articles and documentsAll total 2 Articles be found

Discovery of the first inhibitors of bacterial enzyme D-aspartate ligase from Enterococcus faecium (Aslfm)

?kedelj, Veronika,Perdih, Andrej,Brvar, Matja?,Krofli?, Ana,Dubbée, Vincent,Savage, Victoria,O'Neill, Alex J.,Solmajer, Tom,Be?ter-Roga?, Marija,Blanot, Didier,Hugonnet, Jean-Emmanuel,Magnet, Sophie,Arthur, Michel,Mainardi, Jean-Luc,Stojan, Jure,Zega, Anamarija

, p. 208 - 220 (2013)

The D-aspartate ligase of Enterococcus faecium (Aslfm) is an attractive target for the development of narrow-spectrum antibacterial agents that are active against multidrug-resistant E. faecium. Although there is currently little available information regarding the structural characteristics of Aslfm, we exploited the knowledge that this enzyme belongs to the ATP-grasp superfamily to target its ATP binding site. In the first design stage, we synthesized and screened a small library of known ATP-competitive inhibitors of ATP-grasp enzymes. A series of amino-oxazoles derived from bacterial biotin carboxylase inhibitors showed low micromolar activity. The most potent inhibitor compound 12, inhibits Aslfm with a Ki value of 2.9 μM. In the second design stage, a validated ligand-based pharmacophore modeling approach was used, taking the newly available inhibition data of an initial series of compounds into account. Experimental evaluation of the virtual screening hits identified two novel structural types of Aslfm inhibitors with 7-amino-9H-purine (18) and 7-amino-1H-pyrazolo[3,4-d]pyrimidine (30 and 34) scaffolds, and also with Ki values in the low micromolar range. Investigation the inhibitors modes of action confirmed that these compounds are competitive with respect to the ATP molecule. The binding of inhibitors to the target enzyme was also studied using isothermal titration calorimetry (ITC). Compounds 6, 12, 18, 30 and 34 represent the first inhibitors of Aslfm reported to date, and are an important step forward in combating infections due to E. faecium.

Studies on Decarboxylation Reactions. Part 7. Kinetic Study of the Decarboxylation of 2-Amino- and 2-Phenylamino-thiazole-5-carboxylic Acids

Noto, Renato,Ciofalo, Maurizio,Buccheri, Francesco,Werber, Guiseppe,Spinelli, Domenico

, p. 349 - 352 (2007/10/02)

The rate constants of the decarboxylation reaction of 2-amino- and 2-phenylamino-thiazole-5-carboxylic acid (3a-b), and, for comparison, of 5-phenylamino-1,3,4-thiadiazole-2-carboxylic acid (2b) have been measured in water over a range of proton activities.The results obtained suggest: (i) compound 2b decarboxylates, in the whole range of proton activity studied, through a unimolecular decarboxyprotonation mechanism characteristic of 1,3,4-oxa- and 1,3,4-thiadiazole derivatives; (ii) in contrast, 3a-b decarboxylate via either a unimolecular decarboxyprotonation or a bimolecular protiodecarboxylation mechanism as a function of proton activity.

Process route upstream and downstream products

Process route

2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

2-aminothiazole-5-carboxylic acid
40283-46-3

2-aminothiazole-5-carboxylic acid

Conditions
Conditions Yield
With sodium hydroxide; In tetrahydrofuran; water; Reflux;
86%
With sodium hydroxide;
With barium dihydroxide;
With potassium hydroxide; In methanol;
methyl 2-aminothiazole-5-carboxylate
6633-61-0

methyl 2-aminothiazole-5-carboxylate

2-aminothiazole-5-carboxylic acid
40283-46-3

2-aminothiazole-5-carboxylic acid

Conditions
Conditions Yield
With sodium hydroxide; Ambient temperature;
74%
2-acetylamino-thiazole-5-carbonitrile
99903-61-4

2-acetylamino-thiazole-5-carbonitrile

2-aminothiazole-5-carboxylic acid
40283-46-3

2-aminothiazole-5-carboxylic acid

Conditions
Conditions Yield
With hydrogenchloride;
2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

2-aminothiazole-5-carboxylic acid
40283-46-3

2-aminothiazole-5-carboxylic acid

Conditions
Conditions Yield
With sodium hydroxide; In tetrahydrofuran; water; Reflux;
86%
With sodium hydroxide;
With barium dihydroxide;
With potassium hydroxide; In methanol;
methyl 2-aminothiazole-5-carboxylate
6633-61-0

methyl 2-aminothiazole-5-carboxylate

2-aminothiazole-5-carboxylic acid
40283-46-3

2-aminothiazole-5-carboxylic acid

Conditions
Conditions Yield
With sodium hydroxide; Ambient temperature;
74%
2-acetylamino-thiazole-5-carbonitrile
99903-61-4

2-acetylamino-thiazole-5-carbonitrile

2-aminothiazole-5-carboxylic acid
40283-46-3

2-aminothiazole-5-carboxylic acid

Conditions
Conditions Yield
With hydrogenchloride;

Global suppliers and manufacturers

Global( 85) Suppliers
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  • Chemwill Asia Co., Ltd.
  • Business Type:Manufacturers
  • Contact Tel:021-51086038
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  • Main Products:30
  • Country:China (Mainland)
  • Amadis Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-571-89925085
  • Emails:sales@amadischem.com
  • Main Products:29
  • Country:China (Mainland)
  • Shanghai Upbio Tech Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-21-52196435
  • Emails:upbiocn@hotmail.com
  • Main Products:88
  • Country:China (Mainland)
  • Career Henan Chemical Co
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-371-86658258
  • Emails:purchase@coreychem.com
  • Main Products:137
  • Country:China (Mainland)
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