4038-97-5 Usage
General Description
7-Methoxy-4-(piperazin-1-yl)quinoline is a chemical compound with the molecular formula C16H19N3O. It is a quinoline derivative with a piperazine moiety attached to the fourth position. 7-METHOXY-4-(PIPERAZIN-1-YL)QUINOLINE has been studied for its potential pharmacological effects, including its activity as a serotonin receptor antagonist and its potential use in drug development for conditions such as anxiety, depression, and schizophrenia. Its molecular structure suggests that it may have affinity for certain neurotransmitter receptors in the brain, making it an interesting compound for further research in the field of medicinal chemistry and neuroscience.
Check Digit Verification of cas no
The CAS Registry Mumber 4038-97-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,0,3 and 8 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 4038-97:
(6*4)+(5*0)+(4*3)+(3*8)+(2*9)+(1*7)=85
85 % 10 = 5
So 4038-97-5 is a valid CAS Registry Number.
InChI:InChI=1/C14H17N3O/c1-18-11-2-3-12-13(10-11)16-5-4-14(12)17-8-6-15-7-9-17/h2-5,10,15H,6-9H2,1H3
4038-97-5Relevant articles and documents
Engineering another class of anti-tubercular lead: Hit to lead optimization of an intriguing class of gyrase ATPase inhibitors
Jeankumar, Variam Ullas,Reshma, Rudraraju Srilakshmi,Vats, Rahul,Janupally, Renuka,Saxena, Shalini,Yogeeswari, Perumal,Sriram, Dharmarajan
, p. 216 - 231 (2016/07/07)
A structure based medium throughput virtual screening campaign of BITS-Pilani in house chemical library to identify novel binders of Mycobacterium tuberculosis gyrase ATPase domain led to the discovery of a quinoline scaffold. Further medicinal chemistry explorations on the right hand core of the early hit, engendered a potent lead demonstrating superior efficacy both in the enzyme and whole cell screening assay. The binding affinity shown at the enzyme level was further corroborated by biophysical characterization techniques. Early pharmacokinetic evaluation of the optimized analogue was encouraging and provides interesting potential for further optimization.
