405-05-0 Usage
Uses
Different sources of media describe the Uses of 405-05-0 differently. You can refer to the following data:
1. 3-Fluoro-4-hydroxybenzaldehyde can be used to synthesize 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic Acid, which is an impurity and intermediate in the preparation of Roflumilast.
2. 3-Fluoro-4-hydroxybenzaldehyde can be used to synthesize 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic Acid (C988720), which is an impurity and intermediate in the preparation of Roflumilast (R639700).
Chemical Properties
White crystalline powder
Check Digit Verification of cas no
The CAS Registry Mumber 405-05-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,0 and 5 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 405-05:
(5*4)+(4*0)+(3*5)+(2*0)+(1*5)=40
40 % 10 = 0
So 405-05-0 is a valid CAS Registry Number.
405-05-0Relevant articles and documents
Inhibition of Acyl-CoA: Cholesterol acyltransferase (ACAT), overexpression of cholesterol transporter gene, and protection of amyloid β (Aβ) oligomers-induced neuronal cell death by tricyclic pyrone molecules
Pokhrel, Laxman,Maezawa, Izumi,Nguyen, Thi D. T.,Chang, Kyeong-Ok,Jin, Lee-Way,Hua, Duy H.
, p. 8969 - 8973 (2013/01/15)
A major effort in Alzheimers disease therapeutic development has targeted Aβ and downstream events. We have synthesized a small library of tricyclic pyrone compounds. Their protective action in MC65 cells and inhibition of ACAT along with the upregulation of cholesterol transporter gene were investigated. Five active compounds exhibited potencies in the nanomolar ranges. The multiple effects of the compounds on Aβ and cellular cholesterol pathways could be potential mechanisms underlying the protective effects in vivo.
