40515-82-0

Basic information

• Product Name: Quinoline, 2-phenoxy-
• CAS NO: 40515-82-0
• Molecular Formula: C15H11NO
• Molecular Weight: 221.258
• Mol File: 40515-82-0.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Quinoline, 2-phenoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinoline, 2-phenoxy-(40515-82-0)
• EPA Substance Registry System: Quinoline, 2-phenoxy-(40515-82-0)

Safety Data

• Hazardous Substances Data: 40515-82-0(Hazardous Substances Data)

Upstream product

• 612-62-4 2-Chloroquinoline 
• 139-02-6 sodium phenoxide 
• 36439-44-8 tetramethylammonium phenoxide 
• 108-95-2 phenol 
• 73568-25-9 2-chloro-3-quinoline carboxaldehyde 
• 59-31-4 2-hydroxyquinoline 
• 1613-37-2 Quinoline N-oxide 
• 59-31-4 2-quinolone 
• 93-10-7 quinoline-2-carboxylic acid 
• 115-86-6 phosphoric acid triphenyl ester 

Downstream Products

• 612-96-4 2-Phenylquinoline 
• 67176-94-7 1-phenyl-1,2-dihydro-2-quinolone 
• 59-31-4 2-quinolone 
• 108-95-2 phenol 
• 1415226-45-7 1-amino-3-(2-phenoxyquinolin-3-yl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile 

Relevant articles and documents

Substituent Effects of 2-Pyridones on Selective O-Arylation with Diaryliodonium Salts: Synthesis of 2-Aryloxypyridines under Transition-Metal-Free Conditions

An efficient transition-metal-free strategy to synthesize 2-aryloxypyridine derivatives has been developed by a selective O-arylation of 2-pyridones with diaryliodonium salts. The reaction was compatible with a series of functional groups for 2-pyridones and diaryliodonium salts such as halides, nitro, cyano, and ester groups. The substituents at the C6-position of 2-pyridones favored O-arylation products because of steric hindrance. The reaction was easily performed on a gram-scale and 6-chloro-2-pyridone was a good precursor to access various unsubstituted 2-aryloxypyridines by dehalogenation. A P2Y 1 lead compound analogue could be prepared in good yield over two steps.

Decarbonylative Diaryl Ether Synthesis by Pd and Ni Catalysis

Because diaryl ethers are present as an important motif in pharmaceuticals and natural products, extensive studies for the development of novel methods have been conducted. A conventional method for the construction of the diaryl ether moiety is the intermolecular cross-coupling reaction of aryl halides and phenols with a copper or palladium catalyst. We developed a catalytic decarbonylative etherification of aromatic esters using a palladium or nickel catalyst with our enabling diphosphine ligand to give the corresponding diaryl ethers. The present reaction can be conducted on gram scale in excellent yield. This reaction not only functions in an intramolecular setting but also allows for a cross-etherification using other phenols.

A counteranion triggered arylation strategy using diaryliodonium fluorides

A mild and transition metal-free counteranion triggered arylation strategy has been developed using diaryliodonium fluorides. The fluoride counteranion within the hypervalent iodonium species displays unusual reactivity that activates a phenolic O-H bond leading to electrophilic O-arylation. A wide range of phenols and diaryliodonium salts are compatible with this transformation under remarkably mild conditions. Furthermore, we pre-empt the wider implications of this strategy by demonstrating the compatibility of the arylation tactic with latent carbon nucleophiles.