40567-18-8

Basic information

• Product Name: 1-(2,4,6-Trichlorophenyl)-3-(3-aminobenzamido)-5-pyrazolone
• Synonyms: 3-amino-n-[4,5-dihydro-5-oxo-1-(2,4,6-trichlorophenyl)-1h-pyrazol-3-benzamid;1-(2,4,6-trichlorophenyl)-3-(3-aminobenzamido)-5-pyrazolone;1-(2,4,6-Trichlorophenyl)-3-(3-aminobenzoyl)amino-2-pyrazolin-5-one;3-AMINO-N-[5-OXO-1-(2,4,6-TRICHLOROPHENYL)-1H-PYRAZOLIN-3-YL]BENZAMIDE;3-Amino-N-[4,5-dihydro-5-oxo-1-(2,4,6-trichlorophenyl)-1H-pyrazol-3-yl]-benzamide;1-(2,4,6-Trichlorophenyl)-3-(M-Aminobenzamido)-5-Pyrazolone;3-amino-N-[4,5-dihydro-5-oxo-1-(2,4,6-trichlorophenyl)-1H-pyrazol-3-yl]-Benzamide 3-amino-n-[4,5-dihydro-5-oxo-1-(2,4,6-trichlorophenyl)-1h-pyrazol-3-benzamid;1-(2,4,6-Trichlorophenyl)-3-(3-aminobenzoylamino)-5(4H)-pyrazolone
• CAS NO: 40567-18-8
• Molecular Formula: C₁₆H₁₁Cl₃N₄O₂
• Molecular Weight: 397.64
• EINECS: 254-979-6
• Mol File: 40567-18-8.mol

Chemical Properties

• Appearance: /
• Density: 1.62 g/cm³
• Refractive Index: 1.735
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(2,4,6-Trichlorophenyl)-3-(3-aminobenzamido)-5-pyrazolone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,4,6-Trichlorophenyl)-3-(3-aminobenzamido)-5-pyrazolone(40567-18-8)
• EPA Substance Registry System: 1-(2,4,6-Trichlorophenyl)-3-(3-aminobenzamido)-5-pyrazolone(40567-18-8)

Safety Data

• Hazardous Substances Data: 40567-18-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(2,4,6-Trichlorophenyl)-3-(3-aminobenzamido)-5-pyrazolone is used as an intermediate in the manufacturing of various medications for its anti-inflammatory and analgesic properties.
Used in Nonsteroidal Anti-Inflammatory Drug (NSAID) Development:
TAP is utilized as a key component in the development of NSAIDs, contributing to their efficacy in reducing inflammation and pain.
Used in Analgesic Formulation:
As an analgesic agent, TAP is incorporated into formulations to alleviate pain and discomfort.
Used in Anti-Cancer Research:
TAP is studied for its potential anti-cancer activities, indicating its possible use in the development of cancer treatments.
Used in Anti-Fungal Applications:
1-(2,4,6-Trichlorophenyl)-3-(3-aminobenzamido)-5-pyrazolone's potential anti-fungal properties suggest its use in the creation of anti-fungal medications to combat fungal infections.

InChI:InChI=1/C16H11Cl3N4O2/c17-9-5-11(18)15(12(19)6-9)23-14(24)7-13(22-23)21-16(25)8-2-1-3-10(20)4-8/h1-7,22H,20H2,(H,21,25)

Upstream product

• 121-90-4 m-nitrobenzoic acid chloride 
• 27241-31-2 3-amino-1-(2',4',6'-trichlorophenyl)-4,5-dihydropyrazol-5(1H)-one 
• 63134-25-8 3-(3''-nitrobenzoylamino)-1-(2',4',6'-trichlorophenyl)-4,5-dihydropyrazol-5(1H)-one 

Downstream Products

• 31188-91-7 3-[3-(2'',4''-di-tert-pentyl)phenoxyacetamido]benzoylamino-1-(2',4',6'-trichlorophenyl)-4,5-dihydropyrazol-5(1H)-one 

Relevant articles and documents

Synthesis of 3-(3″-aminobenzoylamido)-1-(2′,4′,6′- trichlorophenyl)pyrazol-5-one, an intermediate in the synthesis of the purple component of color photographic materials

Catalytic reduction of 3-(3″-nitrobenzoylamido)-1-(2′,4′, 6′-trichlorophenyl)pyrazol-5-one with hydrogen and hydrazine hydrate to 3-(3″-aminobenzoylamido)-1-(2′,4′,6′-trichlorophenyl) pyrazol-5-one, the key intermediate in the synthesis of the purple component of color photographic and motion-picture materials, was studied.

Catalytic liquid-phase reduction of aromatic nitro compounds containing highly reactive functional groups

Improved procedures have been proposed for fast and selective hydrogenation of aromatic nitro compounds with the goal of obtaining practically important amines.