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406233-31-6

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406233-31-6 Usage

Chemical Properties

4-Fluoro-3-nitrobenzenesulfonamide is Pale Yellow Solid

Uses

Different sources of media describe the Uses of 406233-31-6 differently. You can refer to the following data:
1. Reagent used to synthesize substituted arylsulfonamide derivatives
2. 4-Fluoro-3-nitrobenzenesulfonamide used to synthesize substituted arylsulfonamide derivatives

Check Digit Verification of cas no

The CAS Registry Mumber 406233-31-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,6,2,3 and 3 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 406233-31:
(8*4)+(7*0)+(6*6)+(5*2)+(4*3)+(3*3)+(2*3)+(1*1)=106
106 % 10 = 6
So 406233-31-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H5FN2O4S/c7-5-2-1-4(14(8,12)13)3-6(5)9(10)11/h1-3H,(H2,8,12,13)

406233-31-6 Well-known Company Product Price

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  • Alfa Aesar

  • (H54516)  4-Fluoro-3-nitrobenzenesulfonamide, 97%   

  • 406233-31-6

  • 250mg

  • 980.0CNY

  • Detail
  • Alfa Aesar

  • (H54516)  4-Fluoro-3-nitrobenzenesulfonamide, 97%   

  • 406233-31-6

  • 1g

  • 2940.0CNY

  • Detail

406233-31-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Fluoro-3-nitrobenzenesulfonamide

1.2 Other means of identification

Product number -
Other names 4-fluoro-3-nitrobenzenesulfonamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:406233-31-6 SDS

406233-31-6Relevant articles and documents

Design, synthesis, and bioactivity evaluation of novel Bcl-2/HDAC dual-target inhibitors for the treatment of multiple myeloma

Zhou, Ruolan,Fang, Shaoyu,Zhang, Minmin,Zhang, Qingsen,Hu, Jian,Wang, Mingping,Wang, Chongqing,Zhu, Ju,Shen, Aijun,Chen, Xin,Zheng, Canhui

, p. 349 - 352 (2019/01/04)

Multiple myeloma (MM) is the second most common haematological malignancy. Almost all patients with MM eventually relapse, and most recommended treatment protocols for the patients with relapsed refractory MM comprise a combination of drugs with different mechanisms of action. Therefore novel drugs are in urgent need in clinic. Bcl-2 inhibitors and HDAC inhibitors were proved their anti-MM effect in clinic or under clinical trials, and they were further discovered to have synergistic interactions. In this study, a series of Bcl-2/HDAC dual-target inhibitors were designed and synthesized. Among them, compounds 7e–7g showed good inhibitory activities against HDAC6 and high binding affinities to Bcl-2 protein simultaneously. They also displayed good growth inhibitory activities against human MM cell line RPMI-8226, which proved their potential value for the treatment of multiple myeloma.

Amplified synthesis method of 3-nitro-4-halogeno-benzenesulfonamide

-

, (2017/08/29)

An amplified synthesis method of 3-nitro-4-halogeno-benzenesulfonamide is disclosed. According to the method, 4-halogeno-benzenesulfonyl chloride which is used as a raw material undergoes nitration to prepare 3-nitro-4-halogeno-benzenesulfonyl chloride; and after aminolysis, 3-nitro-4-halogeno-benzenesulfonamide is prepared. By the synthesis method provided by the invention, the synthesis route by the adoption of chlorosulfonic acid is changed, and production safety is remarkably raised. The reaction condition is milder and is easy for production control. Thus, mass production of the compound is easier to implement and realize.

Design, synthesis, and activity evaluation of selective inhibitors of anti-apoptotic Bcl-2 proteins: The effects on the selectivity of the P1 pockets in the active sites

Wang, Mingping,Tian, Wei,Wang, Chongqing,Lu, Shihai,Yang, Chao,Wang, Juan,Song, Yunlong,Zhou, Youjun,Zhu, Ju,Li, Zhiyu,Zheng, Canhui

, p. 5207 - 5211 (2016/11/09)

The anti-apoptotic Bcl-2 proteins are attractive targets for anti-cancer drug development, and the discovery of their selective inhibitors has become a research focus. In this Letter, obvious differences in the P1 pocket of the active site between Bcl-2, Bcl-xL, and Mcl-1 proteins were proposed by the structural comparison of these proteins. As a result, the groups in their inhibitors binding to the P1 pockets may have significant effect on the selectivity for these proteins. Based on this hypothesis, five types of derivatives of the lead compound B-1 were designed, and several highly selective inhibitors of Bcl-xL(E-1) or Mcl-1 proteins (G) were found. The selective inhibitors of Mcl-1 protein found in this Letter provide new structural types for the development of novel antitumor agents.

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