40651-95-4

Basic information

• Product Name: 2-aMino-2-cyclohexylacetonitrile
• Synonyms: 2-aMino-2-cyclohexylacetonitrile
• CAS NO: 40651-95-4
• Molecular Formula: C₈H₁₄N₂
• Molecular Weight: 138.21016
• Mol File: 40651-95-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2-aMino-2-cyclohexylacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-aMino-2-cyclohexylacetonitrile(40651-95-4)
• EPA Substance Registry System: 2-aMino-2-cyclohexylacetonitrile(40651-95-4)

Safety Data

• Hazardous Substances Data: 40651-95-4(Hazardous Substances Data)

Usage

General Description

2-Amino-2-cyclohexylacetonitrile is a chemical compound with the molecular formula C8H14N2. It is a derivative of acetonitrile and contains a cyclohexyl group and an amino group. 2-aMino-2-cyclohexylacetonitrile is often used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. It is known for its potential applications in the pharmaceutical industry, particularly in the development of drugs and other medical treatments. Additionally, 2-Amino-2-cyclohexylacetonitrile has properties that make it suitable for use in chemical reactions and as a building block for more complex molecules. It is important to handle this chemical with care and in accordance with proper safety protocols due to its toxic and potentially hazardous nature.

Upstream product

• 2043-61-0 cyclohexanecarbaldehyde 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 143-33-9 sodium cyanide 
• 100007-62-3 2-cyclohexyl-2-hydroxyacetonitrile 

Downstream Products

• 1192372-37-4 5-(4-chlorophenyl)-2-cyclohexyl-3-(3-nitrophenyl)-1H-pyrrole 
• 1192372-36-3 2-cyclohexyl-3,5-diphenyl-1H-pyrrole 
• 1319727-26-8 di-tert-butyl 5-cyclohexyl-2-(4-nitrophenyl)-1H-pyrrole-3,4-dicarboxylate 
• 1319727-20-2 2-cyclohexyl-2-(4-nitrobenzylideneamino)acetonitrile 
• 1319727-25-7 di-tert-butyl 5-cyclohexyl-2-(2-naphthyl)-1H-pyrrole-3,4-dicarboxylate 
• 1319727-19-9 2-cyclohexyl-2-[(2-naphthylmethylene)amino]acetonitrile 
• 1370656-32-8 4-((E)-{[cyano(cyclohexyl)methyl]imino}methyl)benzonitrile 
• 1370656-31-7 C₂₅H₂₄N₄ 
• 1373353-63-9 4-(3-cyclohexyl-9H-β-carbolin-1-yl)benzonitrile 
• 1443442-29-2 2-cyclohexyl-2-(1H-pyrrol-1-yl)acetonitrile 
• 40652-42-4 N-Cyclohexylidenemethyl-formamide 
• 127042-98-2 L-(+)-cyclohexylglycine amide 
• 127042-98-2 D-(-)-cyclohexylglycine amide 
• 14328-51-9 (2S)-amino(cyclohexyl)ethanoic acid 

Relevant articles and documents

Facile Access to 1,4-Disubstituted Pyrrolo[1,2- a ]pyrazines from α-Aminoacetonitriles

An efficient and practical synthetic protocol for the synthesis of 1,4-disubstituted pyrrolo[1,2- a ]pyrazine derivatives is described that originates from α-substituted pyrroloacetonitriles which, in turn, are readily available from aryl and alkyl aldehydes. The α-pyrroloacetonitriles were subjected to a Friedel-Crafts acylation with methyl chlorooxoacetate followed by reduction of the nitrile group under Pd-catalyzed hydrogenation conditions and finally aromatization with DDQ leading to the desired pyrrolo[1,2- a ]pyrazine derivatives. This method was generalized and successfully applied to various aryl, heteroaryl, and alkyl substrates. The developed protocol provides direct and convenient access to 1,4-disubstituted ring systems in moderate to good overall yields (51-68percent) without the need for purification of the intermediates. Further functionalization via the stepwise halogenation (bromination, iodination) and nitration was also demonstrated. In addition, the potential of the ester functionality for elaboration was demonstrated by manipulating into heterocyclic ring systems, exemplified by conversion into benzoxazole derivatives.

Pyrroles and indolizidines from deprotonated α-(alkylideneamino) nitriles

Their ready availability from simple starting materials in only two synthetic steps and their versatility as building blocks for the construction of highly substituted amines and N-heterocycles renders α-(alkylideneamino) nitriles useful synthetic intermediates. Herein, short syntheses of tri- and tetrasubstituted pyrroles including the northern half of the HMG-CoA reductase inhibitor atorvastatin as well as an access to 3-substituted indolizidines will be described. Georg Thieme Verlag Stuttgart - New York.