40750-59-2

Basic information

• Product Name: 3,4-DICHLORO-N-METHYLANILINE
• Synonyms: BUTTPARK 62\04-19;3,4-DICHLORO-N-METHYLANILINE;N1-METHYL-3,4-DICHLOROANILINE;N-Methyl-3,4-dichloroaniline;N1-Methyl-3,4-dichloroaniline, 95+%;n-(3,4-dichlorophenyl)-n-methylamine;3,4-Dichloro-N-methylaniline ,97%;3,4-dichloro-N-(2-isopropyl-5-methylcyclohexyl)aniline
• CAS NO: 40750-59-2
• Molecular Formula: C₇H₇Cl₂N
• Molecular Weight: 176.04
• EINECS: -0
• Product Categories: Amines;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het;C7;Nitrogen Compounds
• Mol File: 40750-59-2.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 150-152 °C15 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.3794 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00241mmHg at 25°C
• Refractive Index: n20/D 1.6015(lit.)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 3.36±0.25(Predicted)
• BRN: 2962410
• CAS DataBase Reference: 3,4-DICHLORO-N-METHYLANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DICHLORO-N-METHYLANILINE(40750-59-2)
• EPA Substance Registry System: 3,4-DICHLORO-N-METHYLANILINE(40750-59-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: 2810
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 40750-59-2(Hazardous Substances Data)

Usage

General Description

3,4-Dichloro-N-methylaniline, also known as dichloroaniline, is a chemical compound with the molecular formula C7H7Cl2N. It is a pale yellow solid that is often used as an intermediate in the production of various dyes and pigments. This aromatic amine is also used in the manufacturing of pharmaceuticals and as a pesticide. However, exposure to this chemical can be toxic and harmful to human health, leading to irritation of the skin, eyes, and respiratory system. It is important to handle and store 3,4-Dichloro-N-methylaniline with caution and to follow proper safety measures when working with this chemical.

InChI:InChI=1/C7H7Cl2N/c1-10-5-2-3-6(8)7(9)4-5/h2-4,10H,1H3

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 95-76-1 m,p-dichloroaniline 
• 67-56-1 methanol 
• 58566-66-8 3,4-dichloro-N,N-dimethylaniline 
• 50-00-0 formaldehyd 
• 25217-40-7 (3,4-dichlorophenyl)carbamic acid tert-butyl ester 
• 74-88-4 methyl iodide 
• 5470-15-5 N-(3,4-dichlorophenyl)formamide 
• 88010-39-3 2-(N-Methyl-3,4-dichloranilino)-2-phenylacetonitril 
• 88010-41-7 2-(N-Methyl-3,4-dichloranilino)-2-methyl-2-phenylacetonitril 

Downstream Products

• 13680-69-8 N-methyl-N-(3,4-dichlorophenyl)carbamoyl chloride 
• 95-76-1 m,p-dichloroaniline 

Relevant articles and documents

Method for realizing N-alkylation by using alcohols as carbon source under photocatalysis

The invention discloses a method for realizing N-alkylation by using alcohols as a carbon source under photocatalysis, and belongs to the technical field of catalytic synthesis. Alcohol, a substrate raw material and a catalyst are placed in a reaction device, ultraviolet and/or visible light irradiation is carried out in an inert atmosphere, after the irradiation is finished, solid-liquid separation is carried out to remove the catalyst, and an N-alkylation product can be obtained through extraction, distillation and purification, wherein the substrate raw material comprises any one of an amine compound, an aromatic nitro compound or an aromatic nitrile compound, the alcohol comprises any one or more of soluble primary alcohols, and the catalyst is metal oxide/titanium dioxide or metal sulfide/titanium dioxide. The method is simple and easy to operate, can be used for efficient photocatalysis one-pot multi-step hydrogenation N-alkylation reaction, and is mild in reaction condition, high in chemical selectivity of N-alkylamine, good in catalyst stability and easy to recycle.

Highly Efficient Binuclear Copper-catalyzed Oxidation of N,N-Dimethylanilines with O2

A binuclear copper-salicylate complex, [Cu(Sal)2(NCMe)]2 (Sal=salicylate), was found to be an active catalyst for the oxidation of N,N-dimethylanilines by O2, affording the corresponding N-methyl-N-phenylformamides as major products. The reactions were carried out with a O2 balloon and the S/C (substrate/catalyst ratio) of the model reaction could be up to 1×105, providing a practical and highly efficient catalytic protocol for accessing N-methyl-N-phenylformamides.

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme glycolate oxidase (GO). Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.