40851-66-9Relevant articles and documents
The comparison of protecting methods to the amino group in 2-Aminomethylphenylacetic acid
Zhao, Yougui,Wang, Ronggeng,Liu, Mei
, p. 1637 - 1640 (2014/05/06)
2-Aminomethylphenylacetic acid is an important intermediate of ceforanide, and this article compared two different protecting agents for protecting the amino group in 2-aminomethylphenylacetic acid by BOC (Di-tert butyl dicarbonate) or acetacetic ester, a
Sulfonylamino phenylacetamide derivatives and methods of their use
-
Page 16, (2008/06/13)
Sulfonylamino phenylacetamide derivatives of the general formula are disclosed. Pharmaceutical compositions containing the compounds and methods for their use are also disclosed. In certain embodiments, the compounds of the invention that, preferably: (1) bind with high affinity to κ opioid receptors; (2) display good opioid receptor selectivity of κ versus μ and κ versus δ; and (3) do not substantially inhibit cytochrome P450 enzymatic activity, in particular CYP2D6, CYP2C9 and CYP3A4.