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41051-15-4

41051-15-4

Identification

Synonyms:4-Methoxy-3-oxo-butyricacid methyl ester;4-Methoxy-3-oxobutanoic acid methyl ester;4-Methoxyacetoacetic acid methyl ester;Methyl 4-methoxy-3-oxobutanoate;Methyl4-methoxy-3-oxobutyrate;Methyl g-methoxyacetoacetate;g-Methoxyacetoacetic acid methylester;

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Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi

  • Signal Word:Warning

  • Hazard Statement:H315 Causes skin irritationH319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:Methyl 4-Methoxyacetoacetate
  • Packaging:50g
  • Price:$ 215
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TRC
  • Product Description:Methyl 4-Methoxyacetoacetate
  • Packaging:10g
  • Price:$ 165
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Methyl 4-Methoxyacetoacetate >97.0%(GC)
  • Packaging:25g
  • Price:$ 132
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Methyl 4-Methoxyacetoacetate >97.0%(GC)
  • Packaging:5g
  • Price:$ 47
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:Methyl 4-methoxyacetoacetate 96%
  • Packaging:25 g
  • Price:$ 35
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:Methyl 4-methoxyacetoacetate 96%
  • Packaging:5 g
  • Price:$ 20
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:Methyl 4-methoxyacetoacetate 96%
  • Packaging:100 g
  • Price:$ 125
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Methyl 4-methoxyacetoacetate 97%
  • Packaging:25g
  • Price:$ 193
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Methyl 4-methoxyacetoacetate 97%
  • Packaging:5g
  • Price:$ 78.3
  • Delivery:In stock
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  • Manufacture/Brand:Medical Isotopes, Inc.
  • Product Description:Methyl 4-Methoxyacetoacetate
  • Packaging:50 g
  • Price:$ 695
  • Delivery:In stock
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Relevant articles and documentsAll total 20 Articles be found

-

Brehm,Levenson

, p. 5389 (1954)

-

Preparation method of 4-alkoxyacetoacetate compound

-

Paragraph 0044; 0047; 0048; 0051; 0052; 0055; 0056; 0059, (2020/04/22)

The invention discloses a preparation method of a 4-alkoxyacetoacetate compound, and the method comprises the following steps: reacting a compound I with a first alkali in a first solvent to obtain anintermediate II; reacting the intermediate II obtained in the step (1) with a second alkali in a second solvent to obtain an intermediate III; reacting the intermediate III obtained in the step (2) in an aqueous solution of acid to obtain a product IV, namely the 4-alkoxyacetoacetate compound, wherein X is chlorine, bromine or iodine; wherein R is a C1-C4 alkyl group and a derivative thereof. Thepreparation method provided by the invention has the advantages of simple steps, mild conditions, environmental friendliness, cheap and easily available raw materials, stable supply and low cost, andcreates favorable conditions for reducing the raw material cost of dolutegravir.

NEW ANALOGS AS ANDROGEN RECEPTOR AND GLUCOCORTICOID RECEPTOR MODULATORS

-

Paragraph 0288; 0289; 0291; 0292, (2019/05/16)

The present invention relates to novel dihydropyridine derivatives of formula (I): as modulators of nuclear receptors selected from androgen receptor and glucocorticoid receptor, to processes for their preparation, to pharmaceutical compositions comprising said compounds and to the use of said for manufacturing a medicament for the treatment of pathological conditions or diseases that can improve by modulation of androgen receptor and/or glucocorticoid receptor, selected from cancer, metastasizing cancers, benign prostate hyperplasia, polycystic ovary syndrome (PCOS), hair loss, hirsutism, acne, hypogonadism, muscle wasting diseases, cachexia, Cushing's syndrome, anti-psychotic drug induced weight gain, obesity, post-traumatic stress disorder and alcoholism.

Process route upstream and downstream products

Process route

methanol
67-56-1

methanol

Methyl 4-chloroacetoacetate
32807-28-6,935731-94-5

Methyl 4-chloroacetoacetate

4-methoxyacetoacetic acid methylester
41051-15-4

4-methoxyacetoacetic acid methylester

Conditions
Conditions Yield
methanol; With sodium hydride; In tetrahydrofuran; at 20 ℃;
Methyl 4-chloroacetoacetate; In tetrahydrofuran; at 20 ℃;
93%
With potassium methanolate; sodium hydride; In tetrahydrofuran; mineral oil; at 15 - 25 ℃; for 9h; Concentration; Inert atmosphere;
74 g
With potassium methanolate; sodium hydride; In tetrahydrofuran; mineral oil; at 20 - 25 ℃; for 9h; Reagent/catalyst; Temperature; Inert atmosphere;
89 g
Methyl 4-chloroacetoacetate
32807-28-6,935731-94-5

Methyl 4-chloroacetoacetate

4-methoxyacetoacetic acid methylester
41051-15-4

4-methoxyacetoacetic acid methylester

Conditions
Conditions Yield
With hydrogenchloride; sodium methylate; In water; acetonitrile;
91.7%
With hydrogenchloride; In tetrahydrofuran; methanol; nitrogen; toluene;
107.7 g (74%)
With hydrogenchloride; sodium methylate; acetic acid; In acetonitrile;
methyl 2,4-dimethoxyacetoacetate
130895-62-4

methyl 2,4-dimethoxyacetoacetate

4-methoxyacetoacetic acid methylester
41051-15-4

4-methoxyacetoacetic acid methylester

Conditions
Conditions Yield
With formic acid; In water; at 100 ℃; for 10h; Reagent/catalyst;
72%
{[Cp*Ru(CO)2]2(μ-H)}+OTf-

{[Cp*Ru(CO)2]2(μ-H)}+OTf-

methyl 3-hydroxy-4-methoxybutanoate
382141-76-6

methyl 3-hydroxy-4-methoxybutanoate

4-methoxy-3-oxobutanoic acid
68665-45-2

4-methoxy-3-oxobutanoic acid

4-methoxyacetoacetic acid methylester
41051-15-4

4-methoxyacetoacetic acid methylester

Conditions
Conditions Yield
With hydrogen; In 1,2-dichloro-benzene;
90%
[Cp*Ru(CO)2]2(μ-H)}+OTf-in dichlorobenzene

[Cp*Ru(CO)2]2(μ-H)}+OTf-in dichlorobenzene

methyl 3-hydroxy-4-methoxybutanoate
382141-76-6

methyl 3-hydroxy-4-methoxybutanoate

4-methoxy-3-oxobutanoic acid
68665-45-2

4-methoxy-3-oxobutanoic acid

4-methoxyacetoacetic acid methylester
41051-15-4

4-methoxyacetoacetic acid methylester

Conditions
Conditions Yield
With hydrogen;
90%
Methyl 4-chloroacetoacetate
32807-28-6,935731-94-5

Methyl 4-chloroacetoacetate

sodium methylate
124-41-4

sodium methylate

4-methoxyacetoacetic acid methylester
41051-15-4

4-methoxyacetoacetic acid methylester

Conditions
Conditions Yield
In tetrahydrofuran; methanol; at 50 ℃;
sodium methylate; In tert-butyl methyl ether; acetonitrile; at 25 - 30 ℃; Inert atmosphere;
Methyl 4-chloroacetoacetate; In tert-butyl methyl ether; acetonitrile; at 25 - 55 ℃;
84 g
1-thiopropane
107-03-9

1-thiopropane

ethyl acetoacetate
141-97-9

ethyl acetoacetate

4-methoxyacetoacetic acid methylester
41051-15-4

4-methoxyacetoacetic acid methylester

Conditions
Conditions Yield
With sodium hydroxide; bromine; sodium; In ethanol; water;
C<sub>6</sub>H<sub>9</sub>O<sub>4</sub><sup>(1-)</sup>*Na<sup>(1+)</sup>

C6H9O4(1-)*Na(1+)

4-methoxyacetoacetic acid methylester
41051-15-4

4-methoxyacetoacetic acid methylester

Conditions
Conditions Yield
With acetic acid; for 0.5h;
110 g
monomethyl monopotassium malonate
38330-80-2

monomethyl monopotassium malonate

1-(1H-imidazol-1-yl)-2-methoxyethanone
31059-08-2

1-(1H-imidazol-1-yl)-2-methoxyethanone

4-methoxyacetoacetic acid methylester
41051-15-4

4-methoxyacetoacetic acid methylester

Conditions
Conditions Yield
monomethyl monopotassium malonate; With magnesium chloride; In tetrahydrofuran; at 65 ℃; for 5h; Inert atmosphere;
1-(1H-imidazol-1-yl)-2-methoxyethanone; In tetrahydrofuran; at 30 ℃; for 24h; Inert atmosphere;
methyl methoxyacetate
6290-49-9

methyl methoxyacetate

bromoacetic acid methyl ester
96-32-2

bromoacetic acid methyl ester

4-methoxyacetoacetic acid methylester
41051-15-4

4-methoxyacetoacetic acid methylester

Conditions
Conditions Yield
With zinc; benzene;

Global suppliers and manufacturers

Global( 129) Suppliers
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  • Simagchem Corporation
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  • Chemwill Asia Co., Ltd.
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  • Shaanxi BLOOM TECH Co.,Ltd
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  • Contact Tel:+86-29-86470566
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  • Shanghai Upbio Tech Co.,Ltd
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  • Contact Tel:+86-21-52196435
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  • Main Products:89
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  • Afine Chemicals Limited
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-571-85134551
  • Emails:info@afinechem.com
  • Main Products:96
  • Country:China (Mainland)
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