41253-21-8Relevant articles and documents
Preparation of the pure sodium salt of 1H-1,2,4-triazole
Kazhemekaite,Yuodvirshis,Vektarene
, p. 252 - 253 (1998)
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AZOLE DERIVATIVE, METHOD FOR PRODUCING AZOLE DERIVATIVE, AND INTERMEDIATE COMPOUND
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Page/Page column, (2014/05/07)
In order to provide a novel azole derivative, an azole derivative of the present invention is an azole derivative represented by a general formula (V'). (where R6 and R7 independently represent a hydrogen atom, a C1-C4 alkyl group, a phenyl group, or a benzyl group; X represents a halogen atom, a C1-C4 alkyl group, a haloalkyl group, an alkoxy group or a haloalkoxy group, a phenyl group, a cyano group, or a nitro group; m represents an integer of 0 to 5; and A represents a nitrogen atom or a methyne group.)
PROCESS FOR THE PREPARATION OF ANTICANCER DRUGS
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Page/Page column 16-17, (2008/06/13)
A process for preparing Anastrozole is provided. In the process the steps of a. combining 3,5-bis (2-cyanoisopropyl)toluene, a solvent selected from the group consisting of acetonitrile, dichloromethane and chlorobenzene, a brominating reagent selected from a group consisting of N-bromosuccinimide and l,3-dibromo-5,5-dimethylhydantoin, and 2,2'- azobis(2-methylpropionitrile); b. heating; c. combining with 1,2,4-triazole, a solvent selected from a group consisting of N-methylpyrrolidine, dimethylformamide, mixtures of NMP and DMF, dimethylsulfoxide, mixtures of DMSO and toluene, acetone, ACN, and tetrahydrofuran, a base selected from a group consisting of NaOH, KOH, K2CO3, and Na2CO3, and l,3-benzendiacetonitrile-5- (bromomethyl)-α, α, ?, ?- tetramethyl, at a temperature below -20°C are performed.
IMPROVED PROCESS FOR THE PREPARATION OF HIGH PURITY ANASTROZOLE
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Page/Page column 8; 9-10, (2008/06/13)
Present invention discloses an improved process for the preparation of high purity anastrozole of formula-I (2,2'-[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]di(2-methylpropio-nitrile) consisting of: (i) halogenation of 5, α, α, α', α'-pentamethyl-1,3-benzenediacetonitrile; (ii) reaction with sodium/potassium triazole; (iii) purification of crude anastrozole (containing more than 1% of triazole isomeric impurity) through salt formation; and (iv) isolation of pure anastrozole from its salts. It is observed that the removal of triazole isomeric impurity is possible only through a salt formation.