41371-53-3 Usage
Uses
Used in Pharmaceutical Industry:
2-IMIDAZOLIDONE-4-CARBOXYLIC ACID is used as an intermediate for the synthesis of human BACE-1 inhibitors with a cyclic urea structure. These inhibitors are essential in the development of drugs targeting neurodegenerative diseases such as Alzheimer's.
2-IMIDAZOLIDONE-4-CARBOXYLIC ACID is also used as a reactant for the synthesis of thiophene-3-carboxamides, which are known as kinase inhibitors. Kinase inhibitors play a significant role in the treatment of various cancers by regulating cellular processes and signaling pathways.
Additionally, 2-IMIDAZOLIDONE-4-CARBOXYLIC ACID is used as an additive for crystal nucleation and growth. This application is vital in the development of new materials and the improvement of existing ones, as it helps to control the size, shape, and properties of the crystals formed during the synthesis process.
Check Digit Verification of cas no
The CAS Registry Mumber 41371-53-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,1,3,7 and 1 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 41371-53:
(7*4)+(6*1)+(5*3)+(4*7)+(3*1)+(2*5)+(1*3)=93
93 % 10 = 3
So 41371-53-3 is a valid CAS Registry Number.
InChI:InChI=1/C4H6N2O3/c7-3(8)2-1-5-4(9)6-2/h2H,1H2,(H,7,8)(H2,5,6,9)/t2-/m0/s1
41371-53-3Relevant articles and documents
Synthesis, SAR, and X-ray structure of human BACE-1 inhibitors with cyclic urea derivatives
Park, Heuisul,Min, Kyeongsik,Kwak, Hyo-Shin,Koo, Ki Dong,Lim, Dongchul,Seo, Sang-Won,Choi, Jae-Ung,Platt, Bettina,Choi, Deog-Young
, p. 2900 - 2904 (2008/12/22)
We describe synthesis and evaluation of a series of cyclic urea derivatives with hydroxylethylamine isostere. Modification of P3, P1, and P2′ and combination of SAR display a >100-fold increase in potency with good cellular activity (IC50 = 0.1
