41374-14-5Relevant articles and documents
Synthesis of pharmaceutically important heteroaromatics from methyl phenyl sulfone
Yokoyama,Tsuji,Imamoto
, p. 2954 - 2956 (1984)
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Imidazolylalkylthioalkylamino-ethylene derivatives
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, (2008/06/13)
Compounds of the formula STR1 wherein R1 is a straight or branched chain alkynyl group containing from 3 to 9 carbon atoms, inclusive; R2 is hydrogen, (lower)alkyl, halogen or hydroxymethyl; m is 1 or 2, and n is 2 or 3, provided that the sum of m and n is 3 or 4; X and Y each are independently hydrogen, nitro, cyano, --SO2 Ar or --COR3, provided that X and Y are not both hydrogen; R3 is (lower)alkyl, Ar, (lower)alkoxy, amino or (lower)-alkylamino; and Ar is an optionally substituted phenyl group; and nontoxic pharmaceutically acceptable acid addition salts thereof, are potent anti-ulcer agents. Processes for their preparation and novel intermediates are also disclosed.
IMIDAZOLE ALKYLAMINOETHYLENE COMPOUNDS
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, (2008/06/13)
The compounds are ethylene derivatives which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A compound of this invention is 1-nitro-2-methylamino-2-2-((4-methyl-5-imidazolyl)methylthio)-ethylamino!ethylene.