41463-77-8

Basic information

• Product Name: Spiro[3.4]octan-2-one
• Synonyms: Spiro[3.4]octan-2-one;3,3-Tetramethylenecyclobutanone
• CAS NO: 41463-77-8
• Molecular Formula: C₈H₁₂O
• Molecular Weight: 124.18028
• Mol File: 41463-77-8.mol

Chemical Properties

• Boiling Point: 194℃
• Flash Point: 64℃
• Appearance: /
• Density: 1.02
• CAS DataBase Reference: Spiro[3.4]octan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: Spiro[3.4]octan-2-one(41463-77-8)
• EPA Substance Registry System: Spiro[3.4]octan-2-one(41463-77-8)

Safety Data

• Hazardous Substances Data: 41463-77-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Spiro[3.4]octan-2-one is used as a building block for the synthesis of complex organic molecules and pharmaceuticals. Its unique spirocyclic structure makes it a valuable component in the development of new drugs and medicinal compounds.
Used in Flavor and Fragrance Industry:
Spiro[3.4]octan-2-one is used as a flavoring agent in the food industry, providing a fruity, floral aroma. Its pleasant scent makes it a popular choice for enhancing the taste and aroma of various food products.
Used in Medicinal Applications:
Spiro[3.4]octan-2-one is studied for its potential medicinal properties, including its role as a neuroprotective and anti-inflammatory agent. Its ability to protect neurons and reduce inflammation may contribute to the development of new treatments for neurological disorders and inflammatory conditions.

Upstream product

• 1528-30-9 methylenecyclopentane 
• 329187-14-6 1,1-dichlorospiro[3.4]octan-2-one 

Downstream Products

• 1579298-09-1 2-(1-phenylvinyl)spiro[3.4]octan-2-ol 
• 1579298-30-8 (S)-3-(chloromethyl)-3-phenylspiro[4.4]nonan-2-one 
• 1189572-89-1 C₁₄H₂₀O₂ 
• 34177-18-9 spiro[4.4]nonan-2-one 

Relevant articles and documents

Nitrogen-containing ring derivative inhibitor as well as preparation method and application thereof

The invention relates to a nitrogen-containing ring derivative inhibitor as well as a preparation method and an application thereof. In particular, the present invention relates to a compound represented by general formula (I), a preparation method thereof, a pharmaceutical composition containing the compound, and uses of the compound as a P2X3 inhibitor in treatment of P2X3 receptor dysfunction diseases, especially in treatment of neurogenic diseases.

Helical primary structures of 1,3-spiroannelated five-membered rings: (±)-trispiro[4.1.1.4.2.2]heptadecane and (±)-tetraspiro[4.1.1.1.4.2.2.2]heneicosane

A combination of three spiroannelation methods forms the basis for a synthesis of the first two helical hydrocarbons of 1,3-spiroannelated five-membered rings.

Palladium-catalyzed diastereo- and enantioselective Wagner-Meerwein shift: Control of absolute stereochemistry in the C-C bond migration event

Inducing absolute stereochemistry in Wagner-Meerwein shifts was examined in a ring expansion protocol. Initiated by generation of a π-allylpalladium intermediate by hydropalladation of allenes, the ring expansion of allenylcyclobutanol substrates proceeded with excellent diastereo- and enantioselectivities. The results demonstrate that, during the C-C bond migration process, our chiral catalysts can control the stereochemistry of both the π-allylpalladium intermediate and the corresponding migration bond. Moreover, the stereochemical outcome of the reaction can be rationalized very well with the working model of the chiral catalyst. The method provides an efficient way to synthesize highly substituted cyclopentanones with an α-chiral O-tertiary center which has various synthetic applications.

SUBSTITUTED HETEROCYCLIC DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS

Compounds of the general Formula I, wherein X1, X2, X3, X4, X5, X6, X7, R1, R2, R4, R5, R6, R7, R8, R9, R10, Y1, n, m, p and q are defined as above, their preparation and their use as antimicrobial agents.

Pyrrolidine and thiazolidine compounds

Compounds of formula (I): wherein: X1 represents an atom or group selected from CR4aR4b, O, S(O)q1 and NR5, wherein R4a, R4b, q1 and R5 are as defined in the description, m1 represents zero or an integer from 1 to 4 inclusive, m2 represents an integer from 1 to 4 inclusive, n1 and n2, which may be identical or different, each represent an integer from 1 to 3 inclusive, R1 represents hydrogen or a group selected from carboxy, alkoxycarbonyl, optionally substituted carbamoyl and optionally substituted alkyl, R2 represents hydrogen or alkyl, Ak represents an optionally substituted alkylene chain, p represents zero, 1 or 2, R3 represents hydrogen or cyano, X2 and X3, which may be identical or different, each represent either S(O)q2, or CR6aR6b, wherein q2, R6a and R6b are as defined in the description, its optical isomers, where they exist, and its addition salts with a pharmaceutically acceptable acid. Medicinal products containing the same which are useful as DPP-IV inhibitors.

Syntheses of dispiro[2.1.4.1]decane and dispiro[2.0.3.3]decane

Efficient syntheses of the hitherto unknown hydrocarbons dispiro[2.1.4.1]decane and dispiro-[2.0.3.3]decane have been realized through reaction sequences involving spiro[3.4]octan-2-one and spiro[3.4]octan-5-one as key intermediates. (C) 2000 Elsevier Science Ltd.