4153-45-1

Basic information

• Product Name: (4-CHLORO-PHENYL)-THIOPHEN-2-YL-METHANONE
• Synonyms: ART-CHEM-BB B020314;AKOS B020314;AKOS 94087;(4-CHLORO-PHENYL)-THIOPHEN-2-YL-METHANONE
• CAS NO: 4153-45-1
• Molecular Formula: C₁₁H₇ClOS
• Molecular Weight: 222.69
• Mol File: 4153-45-1.mol
• Article Data: 22

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4-CHLORO-PHENYL)-THIOPHEN-2-YL-METHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: (4-CHLORO-PHENYL)-THIOPHEN-2-YL-METHANONE(4153-45-1)
• EPA Substance Registry System: (4-CHLORO-PHENYL)-THIOPHEN-2-YL-METHANONE(4153-45-1)

Safety Data

• Hazardous Substances Data: 4153-45-1(Hazardous Substances Data)

Usage

General Description

(4-CHLORO-PHENYL)-THIOPHEN-2-YL-METHANONE is a chemical compound with the molecular formula C12H8Cl2OS. It is a yellow solid with a molecular weight of 277.16. (4-CHLORO-PHENYL)-THIOPHEN-2-YL-METHANONE is used in pharmaceutical and chemical research as a building block for various organic synthesis processes. It is a derivative of thiophene, containing a chlorine-substituted phenyl group. The compound's structure and properties make it suitable for use in the development of new drugs and materials with potential applications in various industries.

Upstream product

• 188290-36-0 thiophene 
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• 1003-09-4 2-bromothiophene 
• 104-88-1 4-chlorobenzaldehyde 
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• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 74-11-3 para-chlorobenzoic acid 
• 5271-67-0 2-Thiophenecarbonyl chloride 

Downstream Products

• 949934-44-5 (4-chlorophenyl)[4-(pyrrolidin-1-ylmethyl)phenyl](thien-2-yl)methanol 
• 135887-30-8 C₂₂H₁₆Cl₂OS₂ 
• 40310-35-8 (4-chlorophenyl)-(thiophen-2-yl)methanol 
• 25706-30-3 2-(4-Aminobenzoyl)thiophene 

Relevant articles and documents

Phosphine-Free, Heterogeneous Palladium-Catalyzed Atom-Efficient Carbonylative Cross-Coupling of Triarylbismuths with Aryl Iodides: Synthesis of Biaryl Ketones

A novel and highly efficient heterogeneous palladium-catalyzed carbonylative cross-coupling of aryl iodides with triarylbismuths has been developed that proceeds smoothly at atmospheric CO pressure and provides a general and powerful tool for the preparation of various valuable biaryl ketones with high atom economy, good to excellent yield, and recyclability of the catalyst. The reaction is the first example of Pd-catalyzed carbonylative cross-coupling for the construction of biaryl ketones using triarylbismuths as substrates.

Palladacycle-Catalyzed Carbonylative Suzuki-Miyaura Coupling with High Turnover Number and Turnover Frequency

This work reports the carbonylative Suzuki-Miyaura coupling of aryl iodides catalyzed by palladacycles. More importantly, the palladacycles have been used to generate high turnover numbers (TON's) and turnover frequencies (TOF's). A range of aryl iodides can be coupled with arylboronic acids, generating TON's in the range of 106 to 107 and TOF's in the range of 105 to 106 h-1. Comparison of the palladacycles with a conventional palladium source shows their superiority in generating high TON's and TOF's.

The transition-metal-catalyst-free oxidative homocoupling of organomanganese reagents prepared by the insertion of magnesium into organic halides in the presence of MnCl2·2LiCl

Organomanganese reagents were prepared by the insertion of magnesium into aryl halides in the presence of MnCl2·2LiCl. These organomanganese reagents smoothly undergo 1,2-addition, acylation, and Pd-catalyzed cross-coupling with various electrophiles. Especially, the oxidative homocoupling of organomanganese reagents was completed in one pot without an additional transition-metal catalyst.