41555-25-3Relevant articles and documents
Unexpected ring opening of pyrazolines with activated alkynes: synthesis of 1H-pyrazole-4,5-dicarboxylates and chromenopyrazolecarboxylates
Bhimapaka, China Raju,Kolla, Sai Teja,Rayala, Nageswara Rao,Sridhar, Balasubramanian
, p. 334 - 338 (2022/01/20)
1H-Pyrazole-4,5-dicarboxylates and chromenopyrazole carboxylates were prepared by reacting pyrazolines with activated alkynes under neat conditions without a catalyst. The products were formed via unexpected ring opening of pyrazolines with the elimination of styrene/ethylene. These types of transformations are unknown and the products formed were confirmed using their spectral/analytical data. In addition, the structures of compounds 5e and 5n were confirmed by single-crystal X-ray analysis. Control experiments were conducted to support the proposed reaction mechanism.
Preparation method of fully-substituted pyrazole derivative
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Paragraph 0020-0023; 0028, (2019/08/01)
The invention relates to the technical field of organic chemical synthesis, and achieves the purposes by providing a preparation method of a fully-substituted pyrazole derivative. The preparation method comprises the following steps: according to a reacti
Copper(ii) ionic liquid catalyzed cyclization-aromatization of hydrazones with dimethyl acetylenedicarboxylate: A green synthesis of fully substituted pyrazoles
Safaei, Shirin,Mohammadpoor-Baltork, Iraj,Khosropour, Ahmad Reza,Moghadam, Majid,Tangestaninejad, Shahram,Mirkhani, Valiollah
supporting information, p. 2037 - 2042 (2013/10/08)
The Lewis acid room temperature ionic liquid, [n-Bu4P][CuBr 3], was found to be an efficient and reusable catalyst for three component synthesis of fully substituted pyrazoles from the reaction of aldehydes, arylhydrazines and dimethyl acetylenedicarboxylate (DMAD). This catalytic system is simple and chemoselective with high yields.