4160-82-1

Basic information

• Product Name: 3,3-DIMETHYLGLUTARIC ANHYDRIDE
• Synonyms: 3,3-DiMethylglutaric anhydride, 99% 25GR;3,3-DiMethylglutaric anhydride, 99% 5GR;2H-Pyran-2,6(3H)-dione, dihydro-4,4-diMethyl-;3,3'-DIMETHYL GLUTARIC ANHYDRIDE;3,3-DIMETHYLGLUTARIC ANHYDRIDE;BETA-BETA-DIMETHYLGLUTARIC ANHYDRIDE;3,3-Dimethyladipic anhydride;4,4-Dimethyldihydro-2H-pyran-2,6(3H)-dione
• CAS NO: 4160-82-1
• Molecular Formula: C₇H₁₀O₃
• Molecular Weight: 142.15
• EINECS: 223-998-1
• Product Categories: Anhydride Monomers;Monomers;Polymer Science
• Mol File: 4160-82-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 124-126 °C(lit.)
• Boiling Point: 181 °C25 mm Hg(lit.)
• Flash Point: 181°C/25mm
• Appearance: White to off-white/Crystalline Powder
• Density: 1.1643 (rough estimate)
• Vapor Pressure: 0.00119mmHg at 25°C
• Refractive Index: 1.4730 (estimate)
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 3,3-DIMETHYLGLUTARIC ANHYDRIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3-DIMETHYLGLUTARIC ANHYDRIDE(4160-82-1)
• EPA Substance Registry System: 3,3-DIMETHYLGLUTARIC ANHYDRIDE(4160-82-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-36
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 4160-82-1(Hazardous Substances Data)

Usage

Chemical Properties

white to off-white crystalline powder

Uses

3,3-Dimethylglutaric Anhydride acts as a reagent for the synthesis of piscidinol A derivatives and their ability to inhibit HIV-1 protease.

InChI:InChI=1/C7H10O3/c1-7(2)3-5(8)10-6(9)4-7/h3-4H2,1-2H3

Upstream product

• 1070-83-3 tert-Butylacetic acid 
• 13939-06-5 molybdenum hexacarbonyl 
• 61193-04-2 3-(R,S),5-(R,S)-3,5-dicyano-4,4-dimethyl-2,6-dioxopiperidine 
• 1125-11-7 methyldimedone 
• 71-43-2 benzene 
• 67-64-1 acetone 
• 4165-89-3 3,3-Dimethyl-glutarsaeure-mono--ester 
• 4839-46-7 3,3-Dimethylglutaric acid 

Downstream Products

• 74612-20-7 13,13-dimethyl-1,2-didehydrocrotalanine 
• 128684-34-4 4-((R)-1-Methoxycarbonyl-2-phenyl-ethylcarbamoyl)-3,3-dimethyl-butyric acid 
• 79550-96-2 3,3-Dimethyl-pentanedioic acid mono-{1-[4-((E)-7-ethoxy-3,7-dimethyl-oct-2-enyloxy)-phenyl]-propyl} ester 
• 31526-44-0 4-p-Anisoyl-3.3-dimethylbuttersaeure 
• 82296-60-4 4-Dimethylcarbamoyl-3,3-dimethyl-butyric acid (1R,7aR)-7-hydroxymethyl-2,3,5,7a-tetrahydro-1H-pyrrolizin-1-yl ester 
• 82296-59-1 4-Dimethylcarbamoyl-3,3-dimethyl-butyric acid (7R,7aR)-7-hydroxy-5,6,7,7a-tetrahydro-3H-pyrrolizin-1-ylmethyl ester 
• 136122-46-8 β,β-dimethyl-6-chloro-3-((4-chlorophenyl)methyl)-3H-imidazo(4,5-b)pyridine-2-butanoic acid 
• 25115-67-7 N,3,3-trimethylglutarimide 
• 85271-74-5 1-Ethyl 5,5-dimethyl-3-oxo-2-(triphenylphosphonio)-heptanedioate 
• 4839-46-7 3,3-Dimethylglutaric acid 
• 871115-82-1 1,3,4,6-tetra-O-benzyl-2-deoxy-2-(3,3-dimethylglutarimido)-β-D-glucopyranoside 
• 1932-87-2 dibenzyl 3,3-dimethylpentanedioate 
• 128684-21-9 (R)-2-(4-{(S)-5-Amino-5-[(R)-2-(1H-indol-3-yl)-1-((S)-2-methyl-butylcarbamoyl)-ethylcarbamoyl]-pentylcarbamoyl}-3,3-dimethyl-butyrylamino)-3-phenyl-propionic acid; hydrochloride 
• 128684-42-4 (R)-2-(4-{(S)-5-tert-Butoxycarbonylamino-5-[(R)-2-(1H-indol-3-yl)-1-((S)-2-methyl-butylcarbamoyl)-ethylcarbamoyl]-pentylcarbamoyl}-3,3-dimethyl-butyrylamino)-3-phenyl-propionic acid methyl ester 

Relevant articles and documents

A Scalable, Combined-Batch, and Continuous-Flow Synthesis of a Bio-Inspired UV-B Absorber

A new, chromatography-free synthesis for the preparation of an experimental UV-B absorber is reported. A key step of the process is a one-pot partial reduction of a symmetrical imide with a sequential dehydration step. The synthesis uses several continuous-flow steps to increase sample throughput and was used to prepare sufficient material to support further testing activities in >99 % purity.

Synthesis of Cyclic Anhydrides via Ligand-Enabled C–H Carbonylation of Simple Aliphatic Acids

The development of C(sp3)–H functionalizations of free carboxylic acids has provided a wide range of versatile C?C and C?Y (Y=heteroatom) bond-forming reactions. Additionally, C–H functionalizations have lent themselves to the one-step preparation of a number of valuable synthetic motifs that are often difficult to prepare through conventional methods. Herein, we report a β- or γ-C(sp3)–H carbonylation of free carboxylic acids using Mo(CO)6 as a convenient solid CO source and enabled by a bidentate ligand, leading to convenient syntheses of cyclic anhydrides. Among these, the succinic anhydride products are versatile stepping stones for the mono-selective introduction of various functional groups at the β position of the parent acids by decarboxylative functionalizations, thus providing a divergent strategy to synthesize a myriad of carboxylic acids inaccessible by previous β-C–H activation reactions. The enantioselective carbonylation of free cyclopropanecarboxylic acids has also been achieved using a chiral bidentate thioether ligand.

UV ABSORBING COMPOUNDS, COMPOSITIONS COMPRISING SAME AND USES THEREOF

There is provided a range of novel compounds which have been demonstrated to have useful UV absorbing properties. These compounds will find use in a range of applications such as active components in sunscreen formulations, paints, plastics, fabrics, glass and UV protective coatings.