4167-02-6Relevant articles and documents
Novel cationic polyene glycol phospholipids as DNA transfer reagents - Lack of a structure-activity relationship due to uncontrolled self-assembling processes
Opstad, Christer L.,Zeeshan, Muhammad,Zaidi, Asma,Sliwka, Hans-Richard,Partali, Vassilia,Nicholson, David G.,Surve, Chinmay,Izower, Mitchell A.,Bilchuk, Natalia,Lou, Howard H.,Leopold, Philip. L.,Larsen, Helge,Liberska, Alexandra,Khalique, Nada Abdul,Raju, Liji,Flinterman, Marcella,Jubeli, Emile,Pungente, Michael D.
, p. 117 - 136 (2014)
Cationic glycol phospholipids were synthesized introducing chromophoric, rigid polyenoic C20:5 and C30:9 chains next to saturated flexible alkyl chains of variable lengths C6-20:0. Surface properties and liposome formation
Synthesis and properties of a plasmalogen quinone
Leidner,Simpson O'N.,Liu,Horvath,Howell,Dolina
, p. 189 - 192 (1990)
A novel phospholipid quinone bearing hexadecyl ether chains has been synthesized and employed in the preparation of redox-active, quinone-functionalized liposomes.
The 2-acetylthioethyl ester group: A versatile protective group for P-OH-groups
Markwart, Jens C.,Wurm, Frederik R.
, p. 7426 - 7430 (2018)
Phosphodiesters are bridging elements in nucleic acids. In nature and synthesis, their negative charge protects them from hydrolysis and controls their solubility profile. RNA is a promising material for gene technology but cellular uptake is low due to negative charges. Synthetic oligonucleotides were delivered into cells by a prodrug approach relying on the enzymatic release of the polyphosphodiester oligonucleotides. In synthetic chemistry, a protective group for the P–OH functionality is often necessary, e.g. due to solubility or chemical incompatibility. Several methods for P–OH protection were proposed, but often with low selectivity or harsh conditions. Here, we present the 2-acetylthioethyl group as a versatile protective group for low molecular weight or polymeric phosphodiesters, which can be cleaved under acidic conditions in water or by hydrazine in THF to release the P–OH-functionality, but olefins remain intact. This straightforward use allows designing various synthetic polyphosphodiesters, e.g. for flame-retardant or dispersants.
Compounds for determining the activity of phospholipase A2
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Page/Page column 6-7, (2010/11/29)
Compounds for determining the activity of phospholipase A2, are described herein, and include embodiments having formula (1) wherein L1 is derived from an ether (R1—OR2)m, wherein R1 and R2 are independently selected and are derived from a hydrocarbon having 1 to 12 carbon atoms, with m being an integer from 1 to 4, or from a hydrocarbon R having 1 to 20 carbon atoms; F is unsubstituted or substituted pyrene as a flouraphore; Q is a quencher, and L2 is C(O)-L1 or C(O)-L1-NH, wherein L1 is as defined above. These compounds may be used to determine the activity of phospholipase A2, in particular PAF-AH.
