4193-59-3

Basic information

• Product Name: 4-chloro-2,6-di(piperidin-1-yl)pyrimidine
• Synonyms: pyrimidine, 4-chloro-2,6-di-1-piperidinyl-
• CAS NO: 4193-59-3
• Molecular Formula: C₁₄H₂₁ClN₄
• Molecular Weight: 280.7963
• Mol File: 4193-59-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 467.3°C at 760 mmHg
• Flash Point: 236.4°C
• Density: 1.208g/cm³
• Vapor Pressure: 6.6E-09mmHg at 25°C
• Refractive Index: 1.576
• CAS DataBase Reference: 4-chloro-2,6-di(piperidin-1-yl)pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-2,6-di(piperidin-1-yl)pyrimidine(4193-59-3)
• EPA Substance Registry System: 4-chloro-2,6-di(piperidin-1-yl)pyrimidine(4193-59-3)

Safety Data

• Hazardous Substances Data: 4193-59-3(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 3764-01-0 2,4,6-trichloropyrimidine 

Relevant articles and documents

Facile aromatic nucleophilic substitution (SNAr) reactions in ionic liquids: An electrophile-nucleophile dual activation by [Omim]Br for the reaction

A facile aromatic nucleophilic substitution (SNAr) reaction in recyclable [Omim]Br under relatively mild conditions has been described. An electrophile-nucleophile dual activation by [Omim]Br is also discovered based on control experiments, 1H NMR and IR spectroscopies. This chemistry provides an efficient and metal-free approach for the generation of Caryl-X (XS, N, O) bonds, many of which are significant synthetic intermediates or drugs, making this methodology attractive to both synthetic and medicinal chemistry.

Compounds

Compounds of formula I: [in-line-formulae]A-B-C??(I)[/in-line-formulae] and isomers, salts, solvates, chemically protected forms, and prodrugs thereof wherein: B is selected from the group consisting of: ?where RN is H or Me; or B is a divalent C5 heterocyclic residue containing one or two ring heteroatoms; A is: RA3 and RA5 are independently selected from halo, ORO and RAC, where RO is H or Me, and RAC is H or C1-4 alkyl; XA is selected from N and CRA4, where RA4 is selected from H, ORO, CH2OH, CO2H, NHSO2Me and NHCOMe; RA2 and RA6 are independently selected from H, halo and ORO; or RA3 and RA4 together with the carbon atoms to which they are attached, or RA2 and RA3 together with the carbon atoms to which they are attached, may form a C5-6 heterocylic or heteroaromatic ring, containing at least one nitrogen ring atom; where if X is not N, 1, 2, or 3 of RA2 to RA6 are not H; C is: ?where X is selected from N and CH, Y is selected from N and CH, and Z is selected from N and CRC6; RC3 is selected from H, halo and an optionally substituted N-containing C5-7 heterocyclic group; RC5 is a group selected from: ?which group may be selected by one or two C1-4 alkyl groups or a carboxy group; RC6 is H; or, when X and Y are N, RC5 and RC6 (when Z is CRC6) together with the carbon atoms to which they are attached may form a fused C6 aromatic ring selected from the group consisting of: