41966-25-0

Basic information

• Product Name: 2,2-bis(hydroxymethyl)butanal
• Synonyms: 2,2-Bis(hydroxymethyl)butanal; butanal, 2,2-bis(hydroxymethyl)-
• CAS NO: 41966-25-0
• Molecular Formula: C₆H₁₂O₃
• Molecular Weight: 132.1577
• Mol File: 41966-25-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 284.131°C at 760 mmHg
• Flash Point: 139.877°C
• Density: 1.102g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.463
• CAS DataBase Reference: 2,2-bis(hydroxymethyl)butanal(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-bis(hydroxymethyl)butanal(41966-25-0)
• EPA Substance Registry System: 2,2-bis(hydroxymethyl)butanal(41966-25-0)

Safety Data

• Hazardous Substances Data: 41966-25-0(Hazardous Substances Data)

Usage

General Description

2,2-bis(hydroxymethyl)butanal, also known as Mannich base, is a chemical compound with the molecular formula C7H14O3. It is a pale yellow liquid with a mild, sweet odor and is used as a crosslinking agent in the production of polyurethane resins. 2,2-bis(hydroxymethyl)butanal is formed by the condensation of formaldehyde with two molecules of acetaldehyde, followed by the addition of ammonia or an amine. 2,2-bis(hydroxymethyl)butanal is also used as an intermediate in the synthesis of pharmaceuticals and pesticides and as a crosslinking agent in the production of resins and adhesives. It is important to handle this chemical with care and follow safety guidelines and regulations due to its potential hazards and health risks.

Upstream product

• 50-00-0 formaldehyd 
• 123-72-8 butyraldehyde 
• 38433-81-7 2-ethyl-3-hydroxypropanal 

Downstream Products

• 77-99-6 1,1,1-tri(hydroxymethyl)propane 
• 141-53-7 sodium formate 
• 67-56-1 methanol 
• 58828-90-3 trimethylamine-formic acid complex 
• 10097-02-6 2,2-bis(hydroxymethyl)butanoic acid 

Relevant articles and documents

Comparison of activity and selectivity of weakly basic anion-exchange catalysts for the aldolization of butyraldehyde with formaldehyde

Aldols are important intermediates in the production of polyols, which are raw material for lubricants, surface coatings, and synthetic resins. The activities and selectivities of gel-type and macroporous anion-exchange resin catalysts in the aldolization of butyraldehyde with formaldehyde in an aqueous environment were investigated at 60 °C. The experiments were carried out batchwise in a stirred glass reactor, and the reaction products were analyzed with high performance liquid chromatography. Two main products were observed, 2-ethyl-3-hydroxy-2-hydroxy-methylpropanal (trimethylolpropane aldol) and 2-ethyl-propenal (ethylacrolein). The product ratio was strongly dependent on the catalyst. The selectivity with respect to trimethylolpropane aldol varied within the range 2.7-7.3 for the catalysts investigated. Systematic kinetic experiments were carried out at 50-70 °C with the gel-type resin catalyst displaying the highest aldol selectivity. A kinetic model based on molecular mechanisms was able to describe the product distribution.

Process for producing alpha,alpha-bis (hydroxymethyl )alkanal

The present invention provides a process for producing an α,α-bis(hydroxymethyl)alkanal represented by Formula (II): (wherein R represents an alkyl group, a cycloalkyl group, or an aryl group) which comprises reacting an aldehyde represented by Formula (I): [in-line-formulae]R—CH2—CHO??(I) [/in-line-formulae] (wherein R has the same meaning as defined above) with formaldehyde in the presence of a basic catalyst and a phase-transfer catalyst.