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Cas Database

41994-51-8

41994-51-8

Identification

  • Product Name:3-Isoquinolinecarboxylicacid, 1,2,3,4-tetrahydro-, hydrochloride (1:1)

  • CAS Number: 41994-51-8

  • EINECS:

  • Molecular Weight:213.664

  • Molecular Formula: C10H11 N O2 . Cl H

  • HS Code:2933499090

  • Mol File:41994-51-8.mol

Synonyms:3-Isoquinolinecarboxylicacid, 1,2,3,4-tetrahydro-, hydrochloride (6CI,9CI); 1,2,3,4-Tetrahydro-3-isoquinolinecarboxylicacid hydrochloride; 3-Carboxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

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Safety information and MSDS view more

  • Pictogram(s):Xi

  • Hazard Codes:Xi

  • Signal Word:Warning

  • Hazard Statement:H315 Causes skin irritationH319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid hydrochloride 96%
  • Packaging:10g
  • Price:$ 214
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Matrix Scientific
  • Product Description:1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid hydrochloride 97%
  • Packaging:10g
  • Price:$ 378
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Matrix Scientific
  • Product Description:1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid hydrochloride 97%
  • Packaging:1g
  • Price:$ 120
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Chemenu
  • Product Description:1,2,3,4-Tetrahydroisoquinoline-3-carboxylicacidhydrochloride 95%
  • Packaging:25g
  • Price:$ 762
  • Delivery:In stock
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  • Manufacture/Brand:Chemenu
  • Product Description:1,2,3,4-Tetrahydroisoquinoline-3-carboxylicacidhydrochloride 95%
  • Packaging:10g
  • Price:$ 408
  • Delivery:In stock
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  • Manufacture/Brand:Atlantic Research Chemicals
  • Product Description:1,2,3,4-Tetrahydroisoquinoline-3-carboxylicacidhydrochloride 95%
  • Packaging:10gm:
  • Price:$ 159.06
  • Delivery:In stock
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  • Manufacture/Brand:Aronis compounds
  • Product Description:1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid hydrochloride
  • Packaging:100mg
  • Price:$ 80
  • Delivery:In stock
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  • Manufacture/Brand:Aronis compounds
  • Product Description:1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid hydrochloride
  • Packaging:50mg
  • Price:$ 50
  • Delivery:In stock
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  • Manufacture/Brand:Aronis compounds
  • Product Description:1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid hydrochloride
  • Packaging:5mg
  • Price:$ 15
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:1,2,3,4-TETRAHYDRO-3-ISOQUINOLINE CARBOXYLIC ACID HYDROCHLORIDE 95.00%
  • Packaging:10G
  • Price:$ 1284.91
  • Delivery:In stock
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Relevant articles and documentsAll total 2 Articles be found

Novel bifunctional alkylating agents, 5,10-dihydropyrrolo[1,2-b] isoquinoline derivatives, synthesis and biological activity

Chaniyara, Ravi,Kapuriya, Naval,Dong, Huajin,Lee, Pei-Chih,Suman, Sharda,Marvania, Bhavin,Chou, Ting-Chao,Lee, Te-Chang,Kakadiya, Rajesh,Shah, Anamik,Su, Tsann-Long

experimental part, p. 275 - 286 (2011/02/27)

A series of linear pyrrolo[1,2-b]isoquinoline derivatives was synthesized for antitumor evaluation. The preliminary antitumor studies reveal that both bis(hydroxymethyl) and their bis(alkylcarbamate) derivatives show significant antitumor activity in inhibiting various human tumor cell growth in vitro. 1,2-Bis(hydroxymethyl)-3-methyl-5,10-dihydropyrrolo[1,2-b]isoquinoline (20a) was selected for antitumor studies in animal models. The results show that this agent can induce complete tumor remission or significant suppression in nude mice bearing human breast (MX-1) xenograft and ovarian (SK-OV-3) xenografts, respectively. Alkaline agarose gel shifting assay showed that 20a is able to cross-link with DNA. Studies on the cell cycle inhibition revealed that this agent induces cell arrest at G2/M phase. The results warrant further antitumor investigation against other human tumor growth in animal models.

Retroviral protease inhibitors

-

, (2008/06/13)

The present invention provides novel HIV protease inhibitors, pharmaceutical formulations containing those compounds and methods of their use.

Process route upstream and downstream products

Process route

1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid ; hydrochloride
41994-51-8

1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid ; hydrochloride

Conditions
Conditions Yield
With hydrogenchloride; In water; for 4.5h; Reflux;
98%
1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid ; hydrochloride
41994-51-8

1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid ; hydrochloride

Conditions
Conditions Yield
1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid ; hydrochloride
41994-51-8

1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid ; hydrochloride

Conditions
Conditions Yield
With hydrogenchloride; In water; for 4.5h; Reflux;
98%
1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid ; hydrochloride
41994-51-8

1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid ; hydrochloride

Conditions
Conditions Yield

Global suppliers and manufacturers

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  • Amadis Chemical Co., Ltd.
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  • Bide Pharmatech Ltd
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  • ENAO Chemical Co, Limited
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  • Emails:sales@enaochem.com
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