420130-76-3

Basic information

• Product Name: (2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-THIOUREA
• Synonyms: IFLAB-BB F1906-0003;(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-THIOUREA;N-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)THIOUREA;(2,3-dihydro-1,4-benzodioxin-6-yl)thiourea
• CAS NO: 420130-76-3
• Molecular Formula: C9H10N2O2S
• Molecular Weight: 210.25
• Mol File: 420130-76-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-THIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: (2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-THIOUREA(420130-76-3)
• EPA Substance Registry System: (2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-THIOUREA(420130-76-3)

Safety Data

• Hazardous Substances Data: 420130-76-3(Hazardous Substances Data)

Usage

Uses

Used in Chemical Research:
(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-THIOUREA is used as a research compound for studying its properties and potential applications in various fields. Its unique structure may offer insights into the development of new materials or processes.
Used in Pharmaceutical Development:
Although not widely studied, (2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-THIOUREA could be used as a starting point for the development of pharmaceuticals, given the diverse applications of thioureas in this industry. Further research is needed to explore its potential benefits and risks.
Used in Environmental Studies:
(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-THIOUREA may be used in environmental studies to understand its impact on ecosystems and to develop methods for mitigating any harmful effects it may have.
Note: The specific applications listed above are speculative, as the provided materials do not detail the uses of (2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-THIOUREA. (2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-THIOUREA's potential applications would require further research and development to determine its suitability for various industries.

Upstream product

• 713113-96-3 N-(2,3-dihydrobenzo[b][1,4]dioxin-6-ylcarbamothioyl)benzamide 
• 22013-33-8 6-amino-3,4-benzodioxane 

Downstream Products

• 1623781-01-0 4-(4-chlorophenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)thiazol-2-amine hydrobromide 

Relevant articles and documents

Multi-dimensional target profiling of N,4-diaryl-1,3-thiazole-2-amines as potent inhibitors of eicosanoid metabolism

Eicosanoids like leukotrienes and prostaglandins play a considerable role in inflammation. Produced within the arachidonic acid (AA) cascade, these lipid mediators are involved in the pathogenesis of pain as well as acute and chronic inflammatory diseases like rheumatoid arthritis and asthma. With regard to the lipid cross-talk within the AA pathway, a promising approach for an effective anti-inflammatory therapy is the development of inhibitors targeting more than one enzyme of this cascade. Within this study, thirty N-4-diaryl-1,3-thiazole-2- amine based compounds with different substitution patterns were synthesized and tested in various cell-based assays to investigate their activity and selectivity profile concerning five key enzymes involved in eicosanoid metabolism (5-, 12-, 15-lipoxygenase (LO), cyclooxygenase-1 and -2 (COX-1/-2)). With compound 7, 2-(4-phenyl)thiazol-2-ylamino)phenol (ST-1355), a multi-target ligand targeting all tested enzymes is presented, whereas compound 9, 2-(4-(4-chlorophenyl)thiazol-2-ylamino)phenol (ST-1705), represents a potent and selective 5-LO and COX-2 inhibitor with an IC50 value of 0.9 ± 0.2 μM (5-LO) and a residual activity of 9.1 ± 1.1% at 10 μM (COX-2 product formation). The promising characteristics and the additional non-cytotoxic profile of both compounds reveal new lead structures for the treatment of eicosanoid-mediated diseases.

Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors

Sphingosine kinases (SphK1, SphK2) are main regulators of sphingosine-1-phosphate (S1P), which is a pleiotropic lipid mediator involved in numerous physiological and pathophysiological functions. SphKs are targets for novel anti-cancer and anti-inflammatory agents that can promote cell apoptosis and modulate autoimmune diseases. Herein, we describe the design, synthesis and evaluation of an aminothiazole class of SphK inhibitors. Potent inhibitors have been discovered through a series of modifications using the known SKI-II scaffold to define structure-activity relationships. We identified N-(4-methylthiazol-2-yl)-(2,4′-bithiazol)-2′-amine (24, ST-1803; IC50values: 7.3 μM (SphK1), 6.5 μM (SphK2)) as a promising candidate for further in vivo investigations and structural development.