420134-17-4

Basic information

• Product Name: Thiazole, 4-ethyl-4,5-dihydro-2-(1-methylethyl)-, (4R)- (9CI)
• Synonyms: Thiazole, 4-ethyl-4,5-dihydro-2-(1-methylethyl)-, (4R)- (9CI)
• CAS NO: 420134-17-4
• Molecular Formula: C₈H₁₅NS
• Molecular Weight: 157.2764
• Product Categories: ISOPROPYL
• Mol File: 420134-17-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Thiazole, 4-ethyl-4,5-dihydro-2-(1-methylethyl)-, (4R)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Thiazole, 4-ethyl-4,5-dihydro-2-(1-methylethyl)-, (4R)- (9CI)(420134-17-4)
• EPA Substance Registry System: Thiazole, 4-ethyl-4,5-dihydro-2-(1-methylethyl)-, (4R)- (9CI)(420134-17-4)

Safety Data

• Hazardous Substances Data: 420134-17-4(Hazardous Substances Data)

Upstream product

• 420133-78-4 (R)-N-[1-(hydroxymethyl)propyl]-2-methylpropanethioamide 

Downstream Products

• 1241937-47-2 C₁₄H₁₉NS₂ 

Relevant articles and documents

Synthesis and properties of thiazoline based ionic liquids derived from the chiral pool

A novel class of chiral ionic liquids derived from amino alcohols is prepared in multi-gram scale. Their potential in chiral recognition is shown in a preliminary example with racemic Mosher's acid salt.

(N,N) vs. (N,S) chelation of palladium in asymmetric allylic substitution using bis(thiazoline) ligands: A theoretical and experimental study

New thiazoline-containing ligands including non-symmetric bis(thiazolines) and oxazoline-thiazolines were synthesized and then compared to C2-symmetric bis(thiazolines) in the palladium-catalyzed allylic substitution. The experimental results obtained in this study support the hypothesis of a competition between the (N,N) and the (N,S) palladium chelation, when sterically hindered bis(thiazolines) are used as ligands. A quantum chemical study performed on the Pd-complexes derived from three selected ligands, two C2-symmetric bis(thiazolines) and one oxazoline-thiazoline, also supports this hypothesis.

Synthesis of new chiral thiazoline-containing ligands

New chiral ligands, including bi- and tridentate thiazoline derivatives, analogues of known oxazolines, have been synthesized by a general and convenient procedure, starting from dithioesters and commercial enantiopure 2-aminoalcohols. A preliminary test shows the ability of such ligands to act as asymmetric catalysts in Pd-catalyzed allylic substitution reaction.