4205-23-6Relevant articles and documents
Structure of cycloquivinoside a from the aerial part of Astragalus chivensis
Naubeev,Uteniyazov,Isaev,Kachala,Shashkov
, p. 810 - 812 (2012)
The new cycloartane glycoside cycloquivinoside A, 24S-25-methoxycycloartan- 3β,6α,16β,24,25-pentaol 3-O-β-D-glucopyranoside, was isolated from the aerial part of Astragalus chivensis Bunge (Leguminosae). The structure was established based on chemical transformations and 2D spectra (TOCSY, ROESY, HMBC, HSQC, COSY).
Steroidal saponins from Smilax excelsa rhizomes
Ivanova, Antoaneta,Mikhova, Bozhanka,Klaiber, Iris,Dinchev, Dragomir,Kostova, Ivanka
, p. 916 - 924 (2009)
From the n-butanol soluble fraction of the methanol extract of the rhizomes of Smilax excelsa, three new furostanol saponins 3-O-[4-O-acetyl-α-L- rhamnopyranosyl-(1 → 2)-{α-L-rhamnopyranosyl-(1 → 4)}-β-D-glucopyranosyl]-26-O-[β-D-glucopyranosyl]-22α-hydro
Isolation of antioxidant phenolics from Schinopsis brasiliensis based on a preliminary LC-MS profiling
Santos, Clisiane Carla de Souza,Masullo, Milena,Cerulli, Antonietta,Mari, Angela,Estevam, Charles Dos Santos,Pizza, Cosimo,Piacente, Sonia
, p. 45 - 51 (2017)
The phenolic content of the ethanol extract of the stem bark of the Brazilian plant Schinopsis brasiliensis Engl. (Anacardiaceae) has been evaluated together with the antioxidant activity. The good antioxidant activity exhibited in the Trolox Equivalent A
Molecular basis of the 14-3-3 protein-dependent activation of yeast neutral trehalase Nth1
Alblova, Miroslava,Smidova, Aneta,Docekal, Vojtech,Vesely, Jan,Herman, Petr,Obsilova, Veronika,Obsil, Tomas
, p. E9811 - E9820 (2017)
The 14-3-3 proteins, a family of highly conserved scaffolding proteins ubiquitously expressed in all eukaryotic cells, interact with and regulate the function of several hundreds of partner proteins. Yeast neutral trehalases (Nth), enzymes responsible for the hydrolysis of trehalose to glucose, compared with trehalases from other organisms, possess distinct structure and regulation involving phosphorylation at multiple sites followed by binding to the 14-3-3 protein. Here we report the crystal structures of yeast Nth1 and its complex with Bmh1 (yeast 14-3-3 isoform), which, together with mutational and fluorescence studies, indicate that the binding of Nth1 by 14-3-3 triggers Nth1’s activity by enabling the proper 3D configuration of Nth1’s catalytic and calcium-binding domains relative to each other, thus stabilizing the flexible part of the active site required for catalysis. The presented structure of the Bmh1:Nth1 complex highlights the ability of 14-3-3 to modulate the structure of a multidomain binding partner and to function as an allosteric effector. Furthermore, comparison of the Bmh1:Nth1 complex structure with those of 14-3-3:serotonin N-acetyltransferase and 14-3-3:heat shock protein beta-6 complexes revealed similarities in the 3D structures of bound partner proteins, suggesting the highly conserved nature of 14-3-3 affects the structures of many client proteins.
Properties and reactions of 1.2;5.6-di-O-isopropylidene-alpha-ribo-hexafurinos-3-ulose. Synthesis of D-gulose from D-glucose
Meyer zu Reckendorf
, p. 1071 - 1075 (1969)
-
Kochetkov et al.
, p. 109,115 (1977)
An α-glucoside of 1,4-dideoxy-1,4-imino-d-lyxitol with an eleven carbon side chain
Kato, Atsushi,Hollinshead, Jackie,Yamashita, Yukiko,Nakagawa, Shinpei,Koike, Yuriko,Adachi, Isao,Yu, Chu-Yi,Fleet, George W.J.,Nash, Robert J.
, p. 230 - 233 (2010)
The distribution of pyrrolidine-type iminosugars with a long-side chain appears to be restricted to the relatively unrelated plant families Moraceae, Campanulaceae, and Hyacinthaceae. In a search for glycosidase inhibitors in these plant families, we isolated the 1,4-dideoxy-1,4-imino-d-lyxitol (DIL) glucoside bearing the 1,2,11-trihydroxyundec-4-ene side chain at the C-1α position from the roots of Adenophora triphylla. This iminosugar was a powerful and selective inhibitor of coffee bean α-galactosidase, with an IC 50 value of 8 μM.
Orthogonal Active-Site Labels for Mixed-Linkage endo-β-Glucanases
Jain, Namrata,Tamura, Kazune,Déjean, Guillaume,Van Petegem, Filip,Brumer, Harry
, p. 1968 - 1984 (2021/05/26)
Small molecule irreversible inhibitors are valuable tools for determining catalytically important active-site residues and revealing key details of the specificity, structure, and function of glycoside hydrolases (GHs). β-glucans that contain backbone β(1,3) linkages are widespread in nature, e.g., mixed-linkage β(1,3)/β(1,4)-glucans in the cell walls of higher plants and β(1,3)glucans in yeasts and algae. Commensurate with this ubiquity, a large diversity of mixed-linkage endoglucanases (MLGases, EC 3.2.1.73) and endo-β(1,3)-glucanases (laminarinases, EC 3.2.1.39 and EC 3.2.1.6) have evolved to specifically hydrolyze these polysaccharides, respectively, in environmental niches including the human gut. To facilitate biochemical and structural analysis of these GHs, with a focus on MLGases, we present here the facile chemo-enzymatic synthesis of a library of active-site-directed enzyme inhibitors based on mixed-linkage oligosaccharide scaffolds and N-bromoacetylglycosylamine or 2-fluoro-2-deoxyglycoside warheads. The effectiveness and irreversibility of these inhibitors were tested with exemplar MLGases and an endo-β(1,3)-glucanase. Notably, determination of inhibitor-bound crystal structures of a human-gut microbial MLGase from Glycoside Hydrolase Family 16 revealed.
Method for preparing lactic acid through catalytically converting carbohydrate
-
Paragraph 0029-0040, (2020/11/01)
The invention relates to a method for preparing lactic acid through catalytically converting carbohydrate, and in particular, relates to a process for preparing lactic acid by catalytically convertingcarbohydrate under hydrothermal conditions. The method disclosed by the invention is characterized by specifically comprising the following steps: 1) adding carbohydrate and a catalyst into a closedhigh-pressure reaction kettle, and then adding pure water for mixing; 2) introducing nitrogen into the high-pressure reaction kettle to discharge air, introducing nitrogen of 2 MPa, stirring and heating to 160-300 DEG C, and carrying out reaction for 10-120 minutes; 3) putting the high-pressure reaction kettle in an ice-water bath, and cooling to room temperature; and 4) filtering the solution through a microporous filtering membrane to obtain the target product. The method can realize high conversion rate of carbohydrate and high yield of lactic acid, and has the advantages of less catalyst consumption, good circularity, small corrosion to reaction equipment and the like.
Cyprotuoside C and cyprotuoside D, two new cycloartane glycosides from the rhizomes of Cyperus rotundus
Lin, San-Qing,Zhou, Zhong-Liu,Li, Chun-Yan
, p. 96 - 100 (2018/01/05)
Cyprotuoside C (1) and cyprotuoside D (2), two new cycloartane glycosides were isolated from the ethanol extract of the rhizomes of Cyperus rotundus. Their structures were identified as 24R-9,10-seco-cycloartan- 1(10),9(11)-dien-3β,7β,24,25-tetraol 3-O-β-
