Welcome to LookChem.com Sign In|Join Free

Cas Database

4214-79-3

4214-79-3

Identification

  • Product Name:2(1H)-Pyridinone,5-chloro-

  • CAS Number: 4214-79-3

  • EINECS:224-146-1

  • Molecular Weight:129.546

  • Molecular Formula: C5H4ClNO

  • HS Code:29337900

  • Mol File:4214-79-3.mol

Synonyms:2(1H)-Pyridone,5-chloro- (8CI);2-Pyridinol, 5-chloro- (7CI);2-Hydroxy-5-chloropyridine;5-Chloro-1,2-dihydropyridin-2-one;5-Chloro-1H-2-pyridinone;5-Chloro-2(1H)-pyridinone;5-Chloro-2(1H)-pyridone;5-Chloro-2-hydroxypyridine;5-Chloro-2-pyridinol;5-Chloro-2-pyridone;

Post Buying Request Now
Entrust LookChem procurement to find high-quality suppliers faster

Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi

  • Signal Word:Warning

  • Hazard Statement:H315 Causes skin irritationH319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:5-Chloropyridin-2(1H)-one
  • Packaging:5g
  • Price:$ 60
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TCI Chemical
  • Product Description:5-Chloro-2-hydroxypyridine >98.0%(GC)(T)
  • Packaging:25g
  • Price:$ 67
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TCI Chemical
  • Product Description:5-Chloro-2-hydroxypyridine >98.0%(GC)(T)
  • Packaging:5g
  • Price:$ 21
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:5-CHLORO-2(1H)-PYRIDINONE AldrichCPR
  • Packaging:1ea
  • Price:$ 115
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:5-Chloro-2-hydroxypyridine 97%
  • Packaging:10g
  • Price:$ 42.9
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Matrix Scientific
  • Product Description:5-Chloro-2-hydroxypyridine 98%
  • Packaging:50g
  • Price:$ 40
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Matrix Scientific
  • Product Description:5-Chloro-2-hydroxypyridine 98%
  • Packaging:25g
  • Price:$ 24
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Matrix Scientific
  • Product Description:5-Chloro-2-hydroxypyridine 98%
  • Packaging:1g
  • Price:$ 10
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Frontier Specialty Chemicals
  • Product Description:5-Chloro-2-hydroxypyridine 98%
  • Packaging:1g
  • Price:$ 13
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Crysdot
  • Product Description:5-Chloropyridin-2(1H)-one 98%
  • Packaging:25g
  • Price:$ 70
  • Delivery:In stock
  • Buy Now

Relevant articles and documentsAll total 7 Articles be found

5-alkyl-N-substituted aryl pyridone derivative, preparation method thereof and application of derivative

-

Paragraph 0109; 0112-0114, (2019/10/04)

The invention provides a compound as shown in a formula I, or pharmacologically acceptable salt of the compound, or a prodrug of the compound, or a hydrate or solvate of the compound or a crystal form of the compound. The invention further provides a preparation method and an application of the compound. The structurally novel 5-methyl-2(1H) pyridone derivative as shown in the formula I has an obvious inhibiting effect on fibroblast proliferation and fibroblast secretory fiber binding protein (Fn), and the inhibiting effect is more significant than that of a positive drug pirfenidone (PF). The compound has an excellent application prospect in preparation of drugs for treating or preventing diseases such as fibrosis diseases and tumors.

Chemoselective Demethylation of Methoxypyridine

Makino, Kosho,Hasegawa, Yumi,Inoue, Takahide,Araki, Koji,Tabata, Hidetsugu,Oshitari, Tetsuta,Ito, Kiyomi,Natsugari, Hideaki,Takahashi, Hideyo

, p. 951 - 954 (2019/05/10)

A chemoselective demethylation method for various methoxypyridine derivatives has been developed. Treatment of 4-methoxypyridine with L-selectride in THF for 2 h at reflux temperature afforded 4-hydroxypyridine in good yield; no reaction to anisole occurred. The utility of our method was demonstrated by the efficient synthesis of the metabolic substances of the antiulcer agent omeprazole. Chemoselective demethylation at the site of 3,5-dimethyl-4-methoxypyridine in the presence of 4-methoxybenzimidazole was achieved.

Synthesis and structure-activity relationship of 5-substituent-2(1H)- pyridone derivatives as anti-fibrosis agents

Chen, Jun,Lu, Miao-Miao,Liu, Bin,Chen, Zhuo,Li, Qian-Bin,Tao, Li-Jian,Hu, Gao-Yun

scheme or table, p. 2300 - 2302 (2012/04/18)

Pyridone compounds, such as pirfenidone (PFD) and fluorofenidone (AKF-PD), are multi-target anti-fibrotic agents. Using PFD and AKF-PD as the leading compounds, two series of novel (5-substituent)-2(1H)-pyridone compounds were synthesized with the purpose of maintaining multi-targeting property and overcoming the drawbacks of fast metabolism. These derivatives demonstrated good proliferation inhibiting activity against NIH3T3 cells by MTT assay with AKF-PD as the positive control. Compound 5b exhibited a high potent of anti-fibrosis with a IC50 of 0.08 mmol/L about 34 times of AKF-PD. The SAR of pyridone derivatives as anti-fibrosis agents was also discussed.

Convenient chlorination of some special aromatic compounds using N-chlorosuccinimide

Gan, Zongjie,Hu, Bin,Song, Qiao,Xu, Yungen

experimental part, p. 1074 - 1078 (2012/05/04)

Some chlorinated aromatic compounds, including indole, benzofuran, carbazole, pyridine and aniline derivatives, are difficult to obtain through convenient chlorination. We herein report their efficient synthesis through chlorination with N-chlorosuccinimide (NCS). Optimization of the reaction conditions, including the temperature and the choice of solvent, was also investigated. This approach, which is characterized by a facile procedure, comparatively high yields and environmentally friendly features, provides a straightforward and inexpensive route to several chlorinated aromatic compounds. Georg Thieme Verlag Stuttgart · New York.

SPECTROSCOPIC INVESTIGATIONS OF PHASE TRANSITION IN 5-CHLORO-2-PYRIDONE

Raghoottama, P. S.,Soundararajan, S.,Ramakrishna, J.

, p. 371 - 384 (2007/10/02)

Spectroscopic investigation of 5-chloro-2-pyridone has been carried out in the temperature range 77-300 K.At room temperature the 35Cl NQR spectrum shows a single line at 35.618 MHz, but at 250.7 K two lines appear at 35.850 MHZ and 35.840 MHz respectively indicating the presence of a phase transition.IR, far-IR, laser Raman and dielectric measurements have been carried out to investigate the phase transition further.Low temperature IR studies show splitting of ν(C-Cl), β(N-H) and ν(C=O) bands at Tc.Dielectric measurements show a small, but finite, change in the value of the dielectric constant around Tc.Raman spectra at different temperatures support the existence of a new phase, as shown by the appearance of a new band at 81 cm-1, the frequency of which changes slowly as Tc is approached and which disappears at Tc.The temperature dependence of the NQR frequencies has been analysed using Bayer Kushida and Brown equations to evaluate the torsional frequencies.

Process route upstream and downstream products

Process route

5-chloro-2-methoxypyridine
13473-01-3

5-chloro-2-methoxypyridine

5-chloro-2-pyridinol
4214-79-3

5-chloro-2-pyridinol

Conditions
Conditions Yield
With L-Selectride; In tetrahydrofuran; for 3.5h; chemoselective reaction; Reflux; Inert atmosphere;
73%
5-chloro-2-pyridylamine
1072-98-6

5-chloro-2-pyridylamine

5-chloro-2-pyridinol
4214-79-3

5-chloro-2-pyridinol

Conditions
Conditions Yield
With potassium nitrite; sulfuric acid;
With sulfuric acid; water; sodium nitrite; at 10 ℃; for 0.666667h; Green chemistry;
2-hydroxypyridin
142-08-5

2-hydroxypyridin

5-chloro-2-pyridinol
4214-79-3

5-chloro-2-pyridinol

Conditions
Conditions Yield
With N-chloro-succinimide; In acetonitrile; at 25 - 75 ℃; for 1h;
90%
2,5 dichloropyridine
16110-09-1

2,5 dichloropyridine

5-chloro-2-pyridinol
4214-79-3

5-chloro-2-pyridinol

Conditions
Conditions Yield
With hydrogenchloride; at 150 ℃; Unter Druck;
5-chloro-2-pyridinol
4214-79-3

5-chloro-2-pyridinol

Conditions
Conditions Yield
With chloroform; chlorine;
2-aminopyridine
504-29-0

2-aminopyridine

5-chloro-2-pyridinol
4214-79-3

5-chloro-2-pyridinol

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: alcohol; chlorine
2: potassium nitrite; diluted sulfuric acid
With potassium nitrite; ethanol; sulfuric acid; chlorine;
5-chloro-1,2-dihydropyridin-2-one
4214-79-3

5-chloro-1,2-dihydropyridin-2-one

Conditions
Conditions Yield
With sodium hypochlorite; In dichloromethane; Ambient temperature; 1.) 30 s 2.) 24 h;
59%
5-chloro-2-pyridylamine
1072-98-6

5-chloro-2-pyridylamine

5-chloro-1,2-dihydropyridin-2-one
4214-79-3

5-chloro-1,2-dihydropyridin-2-one

Conditions
Conditions Yield
With hydrogenchloride; sodium nitrite;
80%
With sulfuric acid; sodium nitrite; In water;
Multi-step reaction with 2 steps
1: sulfuric acid; sodium nitrite; water / 0.67 h / 10 °C / Green chemistry
2: water / 0.25 h / Reflux; Green chemistry
With sulfuric acid; water; sodium nitrite;
5-chloro-2-pyridinol
4214-79-3

5-chloro-2-pyridinol

5-chloro-1,2-dihydropyridin-2-one
4214-79-3

5-chloro-1,2-dihydropyridin-2-one

Conditions
Conditions Yield
With water; for 0.25h; Reflux; Green chemistry;
0.7 g
5-chloro-1-(4,6-diphenyl-2-pyridylcarbonyl)-2-pyridone
89478-74-0

5-chloro-1-(4,6-diphenyl-2-pyridylcarbonyl)-2-pyridone

5-chloro-1,2-dihydropyridin-2-one
4214-79-3

5-chloro-1,2-dihydropyridin-2-one

4,6-diphenyl-2-(t-butylcarbamoyl)pyridine
89478-85-3

4,6-diphenyl-2-(t-butylcarbamoyl)pyridine

Conditions
Conditions Yield
With tert-butylamine; In chloroform; for 6h; Heating;
70%

Global suppliers and manufacturers

Global( 79) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • Simagchem Corporation
  • Business Type:Manufacturers
  • Contact Tel:+86-592-2680277
  • Emails:sale@simagchem.com
  • Main Products:110
  • Country:China (Mainland)
  • Amadis Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-571-89925085
  • Emails:sales@amadischem.com
  • Main Products:29
  • Country:China (Mainland)
  • Chemwill Asia Co., Ltd.
  • Business Type:Manufacturers
  • Contact Tel:021-51086038
  • Emails:chemwill_asia@126.com
  • Main Products:130
  • Country:China (Mainland)
  • Shaanxi BLOOM TECH Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-29-86470566
  • Emails:sales@bloomtechz.com
  • Main Products:80
  • Country:China (Mainland)
  • Shanghai Upbio Tech Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-21-52196435
  • Emails:upbiocn@hotmail.com
  • Main Products:88
  • Country:China (Mainland)
  • Career Henan Chemical Co
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-371-86658258
  • Emails:purchase@coreychem.com
  • Main Products:137
  • Country:China (Mainland)
close

Please post your buying leads,so that our qualified suppliers will soon contact you!

*Required Fields

CAS No.:
* Product Name:
* Your email:

Your email will be used to sign-in to LookChem.com
* Requirements:
* Valid for:
 
Post Buying Request Now
close
Remarks: The blank with*must be completed