42203-03-2

Basic information

• Product Name: 1-(2-Pyridinyl)-1-hexanone
• Synonyms: 1-(2-Pyridinyl)-1-hexanone;1-(2-Pyridyl)hexan-1-one;Pentyl 2-pyridyl ketone
• CAS NO: 42203-03-2
• Molecular Formula: C11H15NO
• Molecular Weight: 177.25
• Mol File: 42203-03-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 267℃
• Flash Point: 122℃
• Appearance: /
• Density: 0.983
• Vapor Pressure: 0.0086mmHg at 25°C
• Refractive Index: 1.498
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(2-Pyridinyl)-1-hexanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Pyridinyl)-1-hexanone(42203-03-2)
• EPA Substance Registry System: 1-(2-Pyridinyl)-1-hexanone(42203-03-2)

Safety Data

• Hazardous Substances Data: 42203-03-2(Hazardous Substances Data)

Usage

General Description

1-(2-Pyridinyl)-1-hexanone is a chemical compound with the molecular formula C11H15NO. It is also known by its other names such as P2P, alpha-picolinyl methyl ketone, and alpha-acetylphenylacetonitrile. 1-(2-Pyridinyl)-1-hexanone is often used as a precursor in the synthesis of various pharmaceuticals and illicit drugs such as methamphetamine and MDMA. It is a colorless liquid with a faint, pleasant odor, and its main applications include use as a reagent in organic synthesis and as a flavoring agent in the food industry. However, it is important to note that 1-(2-Pyridinyl)-1-hexanone is a controlled substance in many countries due to its potential for misuse in the production of illegal drugs.

InChI:InChI=1/C11H15NO/c1-2-3-4-8-11(13)10-7-5-6-9-12-10/h5-7,9H,2-4,8H2,1H3

Upstream product

• 2524-52-9 ethyl-2-picolinate 
• 23708-48-7 pentamethylenebis(magnesium bromide) 
• 100-70-9 2-Cyanopyridine 
• 693-25-4 n-pentylmagnesium bromide 
• 110-53-2 1-Bromopentane 
• 1121-60-4 pyridine-2-carbaldehyde 
• 109-67-1 1-penten 

Relevant articles and documents

Rhodium Catalyzed Asymmetric Hydrogenation of 2-Pyridine Ketones

Catalyzed by [Rh(COD)Binapine]BF4, the asymmetric hydrogenation of 2-pyridine ketones has been achieved with excellent enantioselectivities (enantiomeric excesses up to 99%) under mild conditions. This method is suitable for various kinds of 2-pyridine ketones and their derivatives. A number of enantiomerically pure chiral 2-pyridine-aryl/alkyl alcohols were prepared through hydrogenation, which can be used directly in organic synthesis.

Aerobic oxidation of secondary benzylic alcohols and direct oxidative amidation of aryl aldehydes promoted by sodium hydride

We reported herein new reactivities and possible mechanistic implications of a simplest oxidant (NaH/air) uncovered on a broad range of useful transformations, including aerobic alcohol oxidations, allylic alcohol isomerizations and oxidations, cyclopropyl alcohol fragmentations, and direct aryl aldehyde oxidative amidations. These readily implementable transition-metal-free processes feature exceptional material accessibility, operational simplicity, and environmental compatibility, and add new dimensions to its synthetic utilities that are fairly robust yet had not previously been fully realized and systematically explored.