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42268-88-2

42268-88-2

Identification

Synonyms:1,3-dimethyl 5-(bromomethyl)benzene-1,3-dicarboxylate

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

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  • Manufacture/Brand:Crysdot
  • Product Description:Dimethyl5-(bromomethyl)isophthalate 97%
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  • Product Description:Dimethyl5-(bromomethyl)isophthalate 97%
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  • Manufacture/Brand:Ambeed
  • Product Description:Dimethyl5-(bromomethyl)isophthalate 97%
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  • Manufacture/Brand:Ambeed
  • Product Description:Dimethyl5-(bromomethyl)isophthalate 97%
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  • Manufacture/Brand:Ambeed
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  • Manufacture/Brand:Alichem
  • Product Description:1,3-Dimethyl5-(bromomethyl)benzene-1,3-dicarboxylate
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  • Manufacture/Brand:Alichem
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Relevant articles and documentsAll total 14 Articles be found

COMPOUND, POLYMER, PATTERN FORMING MATERIAL, AND MANUFACTURING METHOD OF SEMICONDUCTOR DEVICE

-

, (2021/03/13)

A pattern forming material is configured to use for forming an organic film on a film to be processed, patterning the organic film, and then forming a composite film by infiltrating a metallic compound into the patterned organic film. The pattern forming material contains a polymer including a monomer unit represented by a general formula (3) described below, where R21 is H or CH3, each R22 is a hydrocarbon group of C2-14 where α carbon is primary carbon, secondary carbon or tertiary carbon, Q is a single bond or a hydrocarbon group of C1-20 carbon atoms which may include an oxygen atom, a nitrogen atom, or a sulfur atom between carbon-carbon atoms of or at a bond terminal, and a halogen atom may be substituted for the hydrogen atom.

Second-Sphere Interaction Promoted Turn-On Fluorescence for Selective Sensing of Organic Amines in a TbIII-based Macrocyclic Framework

Huang, Xianqiang,Liu, Qingzhi,Liu, Shixi,Ma, Shengqian,Nafady, Ayman,Niu, Zheng,Ren, Junyu,Tsai, Chen-Yen,Ye, Yingxiang

supporting information, p. 23705 - 23712 (2021/09/22)

Guided by a second-sphere interaction strategy, we fabricated a Tb(III)-based metal—organic framework (MMCF-4) for turn-on sensing of methyl amine with ultra-low detection limit and high turn-on efficiency. MMCF-4 features lanthanide nodes shielded in a nonacoordinate geometry along with secondary coordination spheres that are densely populated with H-bond interacting sites. Nonradiative routes were inhibited by binding-induced rigidification of the ligand on the second coordination sphere, resulting in luminescence amplification. Such remote interacting mechanism involved in the turn-on sensing event was confirmed by single-crystal X-ray diffraction and molecular dynamic simulation studies. The design of both primary and secondary coordination spheres of Tb(III) enabled the first turn-on sensing of organic amines in aqueous conditions. Our work suggests a promising strategy for high-performance turn-on sensing for Ln-MOFs and luminous materials driven by other metal chromophores.

Efficient Gene Delivery Based on Guanidyl-Nucleic Acid Molecular Interactions

Wang, Dongli,Song, Jie,Wang, Jing,Zhang, Zhiyi,Shen, Qing,Wang, Jun,Guo, Haiyan,Wang, Ruifeng,Xie, Cao,Lu, Weiyue,Liu, Min

, (2020/09/21)

Low transfection efficacy of non-viral gene vectors restricts their applications. In this paper, N1,N3-dicarbamimidoyl-5-methylisophthalamide (BGG) is designed as a functional group, in which two guanidyls are located at the meta positions of an aryl ring. BGG is conjugated with PAMAM G5 (G5-BGG) and G5-BGG/DNA complex is dispersed into a polyvinyl alcohol (PVA) hydrogel for local injection. Molecular docking, NMR, IR and Isothermal titration calorimetry (ITC) experiments demonstrate that G5-BGG has multiple molecular interactions with nucleic acids, which yield high binding affinity toward nucleic acids. Interestingly, the in vitro transfection efficiency and serum stability of G5-BGG are significantly improved when the BGG modification ratio is just one. The integrated G5-BGG/DNA complex is released from a PVA hydrogel sustainably, crosses the cell membrane and escapes from endosome/lysosome. After local injection only once, these features of the G5-BGG/DNA-loaded PVA hydrogel are found to improve antitumor efficiency in vivo, and antitumor efficiency is significantly better than PEI 25K. The results confirm that BGG is a potential group for developing non-viral gene vectors with high transfection efficacy.

Microporous Cyclen-Based Octacarboxylate Hydrogen-Bonded Organic Framework Exhibiting Selective Gas Adsorption

Stackhouse, Chavis,Ren, Junyu,Shan, Chuan,Nafady, Ayman,Al-Enizi, Abdullah M.,Ubaidullah, Mohd,Niu, Zheng,Ma, Shengqian

, p. 6377 - 6380 (2019/10/11)

A microporous hydrogen-bonded organic framework (HOF) was successfully prepared by a cyclen-based octacarboxylate ligand H8tacnip-Zn. The obtained three-dimensional structure presents a periodic double-layer unit that stacks to form a one-dimensional channel that buttresses discrete cavities (~5.6 × 5.6 ?2). From the single crystal structure, the macrocycle-bound metal ion was proven to greatly enhance the rigidity of the cyclen-based ligand while adjusting the direction of the carboxyl groups. The indelible porosity of degassed HOF was elucidated by CO2 sorption and selective gas adsorption. This work provides facile access to construct more porous HOFs based on a cyclen unit.

Manganese cluster-based MOF as efficient polysulfide-trapping platform for high-performance lithium-sulfur batteries

Liu, Xiao-Fei,Guo, Xiao-Qing,Wang, Rui,Liu, Qing-Chao,Li, Zhong-Jun,Zang, Shuang-Quan,Mak, Thomas C. W.

supporting information, p. 2838 - 2844 (2019/02/12)

Lithium-sulfur (Li-S) batteries have attracted wide attention due to their outstanding properties of high theoretical specific capacity and energy density. However, drawbacks such as the polysulfide shuttle effect have hampered their further practical application. Metal-organic frameworks (MOFs) have stimulated increasing interest in energy storage and conversion. In MOFs, the metal ions can be activated to provide open metal Lewis acid sites to restrain polysulfides. Aiming at sensible solutions, a novel manganese cluster-based MOF equipped with cubic cages, which are walled with abundant open-metal sites (OMSs) obtained from 9-manganese nodes, is used as the cathode host of Li-S batteries. The activated MOF not only provided physical capture and chemical adsorption against polysulfide shuttle but also allowed efficient impregnation of sulfur to facilitate mass transport. Benefiting from these synergetic effects, the composite cathode delivers enhanced electrochemical performance. The battery showed a remaining capacity of about 990 mA h g-1 after 200 cycles at 0.2C and an approximately repeatable rate performance. Significant contribution of the exposed functional metal sites was demonstrated by XPS and SEM of the electrode materials.

Process route upstream and downstream products

Process route

5-Methylisophthalsaeure-dimethylester
17649-58-0

5-Methylisophthalsaeure-dimethylester

1,3-dimethyl 5-(bromomethyl)benzene-1,3-dicarboxylate
42268-88-2

1,3-dimethyl 5-(bromomethyl)benzene-1,3-dicarboxylate

Conditions
Conditions Yield
With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; Inert atmosphere; Schlenk technique; Reflux;
75%
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In dichloromethane; Heating; Irradiation;
69%
With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 12h; Reflux;
65.48%
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In dichloromethane; for 5h; Heating; Irradiation;
64%
With N-Bromosuccinimide; dibenzoyl peroxide; In acetonitrile; at 90 ℃; for 6h;
64%
With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 24h; Reflux;
62%
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 6h; Reflux;
47%
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 6h; Reflux;
47%
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; Reflux;
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; Reflux;
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; at 80 ℃; for 12.75h;
5.80 g
With N-Bromosuccinimide; In tetrachloromethane; Reflux;
dimethyl 5-hydroxymethylbenzene-1,3-dicarboxylate
109862-53-5

dimethyl 5-hydroxymethylbenzene-1,3-dicarboxylate

1,3-dimethyl 5-(bromomethyl)benzene-1,3-dicarboxylate
42268-88-2

1,3-dimethyl 5-(bromomethyl)benzene-1,3-dicarboxylate

Conditions
Conditions Yield
With carbon tetrabromide; triphenylphosphine; In dichloromethane; for 3h; Inert atmosphere;
86.9%
With N-Bromosuccinimide; triphenylphosphine; In dichloromethane; at 0 ℃; for 1h;
5-methylisophthalic aicd
499-49-0

5-methylisophthalic aicd

1,3-dimethyl 5-(bromomethyl)benzene-1,3-dicarboxylate
42268-88-2

1,3-dimethyl 5-(bromomethyl)benzene-1,3-dicarboxylate

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: sulfuric acid / 12 h / 20 °C / Reflux
2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 24 h / Reflux
With N-Bromosuccinimide; sulfuric acid; dibenzoyl peroxide; In tetrachloromethane;
Multi-step reaction with 2 steps
1: sulfuric acid / 80 °C
2: N-Bromosuccinimide; dibenzoyl peroxide / acetonitrile / 6 h / 90 °C
With N-Bromosuccinimide; sulfuric acid; dibenzoyl peroxide; In acetonitrile;
Multi-step reaction with 2 steps
1: toluene-4-sulfonic acid / 12 h / 20 °C / Inert atmosphere; Schlenk technique; Reflux
2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / Inert atmosphere; Schlenk technique; Reflux
With N-Bromosuccinimide; toluene-4-sulfonic acid; dibenzoyl peroxide; In tetrachloromethane;
Multi-step reaction with 2 steps
1: sulfuric acid / 10 h / 80 °C
2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / Reflux
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; In tetrachloromethane;
Multi-step reaction with 2 steps
1: sulfuric acid / Reflux
2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / Reflux
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; In tetrachloromethane;
Multi-step reaction with 2 steps
1: sulfuric acid / Reflux
2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 6 h / Reflux
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; In tetrachloromethane;
Multi-step reaction with 2 steps
1: sulfuric acid / 12 h / 80 °C
2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 12.75 h / 80 °C
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; In tetrachloromethane;
Multi-step reaction with 2 steps
1: sulfuric acid / 8 h / 80 °C
2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 12 h / Reflux
With N-Bromosuccinimide; sulfuric acid; dibenzoyl peroxide; In tetrachloromethane;
Multi-step reaction with 3 steps
1: thionyl chloride / Reflux
2: triethylamine / tetrahydrofuran
3: N-Bromosuccinimide / tetrachloromethane / Reflux
With N-Bromosuccinimide; thionyl chloride; triethylamine; In tetrahydrofuran; tetrachloromethane;
5-methylisophthaloyl dichloride
13438-29-4

5-methylisophthaloyl dichloride

1,3-dimethyl 5-(bromomethyl)benzene-1,3-dicarboxylate
42268-88-2

1,3-dimethyl 5-(bromomethyl)benzene-1,3-dicarboxylate

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: triethylamine / tetrahydrofuran
2: N-Bromosuccinimide / tetrachloromethane / Reflux
With N-Bromosuccinimide; triethylamine; In tetrahydrofuran; tetrachloromethane;
3,5-dicarbomethoxypyrazole
4077-76-3

3,5-dicarbomethoxypyrazole

1,3-dimethyl 5-(bromomethyl)benzene-1,3-dicarboxylate
42268-88-2

1,3-dimethyl 5-(bromomethyl)benzene-1,3-dicarboxylate

1-(3,5-dicarboxy-benzyl)-1H-pyrazole-3,5-dicarboxylic acid

1-(3,5-dicarboxy-benzyl)-1H-pyrazole-3,5-dicarboxylic acid

Conditions
Conditions Yield
3,5-dicarbomethoxypyrazole; With potassium hydroxide; In N,N-dimethyl-formamide; at 80 ℃; for 0.5h;
1,3-dimethyl 5-(bromomethyl)benzene-1,3-dicarboxylate; In N,N-dimethyl-formamide; at 80 ℃; for 2h;
In water; N,N-dimethyl-formamide; for 3h; Reflux;
85%
1H-imidazole
288-32-4

1H-imidazole

1,3-dimethyl 5-(bromomethyl)benzene-1,3-dicarboxylate
42268-88-2

1,3-dimethyl 5-(bromomethyl)benzene-1,3-dicarboxylate

5-[(imidazol-1-yl)methyl]benzene-1,3-dicarboxylic acid
1393930-96-5

5-[(imidazol-1-yl)methyl]benzene-1,3-dicarboxylic acid

Conditions
Conditions Yield
1H-imidazole; 1,3-dimethyl 5-(bromomethyl)benzene-1,3-dicarboxylate; In methanol; at 20 - 80 ℃; for 24h;
With water; potassium hydroxide; for 10h; Reflux;
88%
4,4'-bipyridine
553-26-4

4,4'-bipyridine

1,3-dimethyl 5-(bromomethyl)benzene-1,3-dicarboxylate
42268-88-2

1,3-dimethyl 5-(bromomethyl)benzene-1,3-dicarboxylate

1,1′-bis(3,5-dicarboxybenzyl)-4,4′-bipyridinium dichloride

1,1′-bis(3,5-dicarboxybenzyl)-4,4′-bipyridinium dichloride

Conditions
Conditions Yield
4,4'-bipyridine; 1,3-dimethyl 5-(bromomethyl)benzene-1,3-dicarboxylate; In acetonitrile; at 10 ℃; for 24h;
With hydrogenchloride; In water; at 100 ℃; for 12h;
86%
ethyl 4-[(E)-2-(4-hydroxyphenyl)diazen-1-yl]benzoate
4418-89-7

ethyl 4-[(E)-2-(4-hydroxyphenyl)diazen-1-yl]benzoate

1,3-dimethyl 5-(bromomethyl)benzene-1,3-dicarboxylate
42268-88-2

1,3-dimethyl 5-(bromomethyl)benzene-1,3-dicarboxylate

dimethyl 5-((4-(4(ethoxycarbonyl)phenylazo)phenoxy)methyl)isophthalate

dimethyl 5-((4-(4(ethoxycarbonyl)phenylazo)phenoxy)methyl)isophthalate

Conditions
Conditions Yield
With potassium carbonate; In N,N-dimethyl-formamide; at 85 ℃; for 10h;
95%
1,3-dimethyl 5-(bromomethyl)benzene-1,3-dicarboxylate
42268-88-2

1,3-dimethyl 5-(bromomethyl)benzene-1,3-dicarboxylate

dimethyl amine
124-40-3

dimethyl amine

dimethyl 5-(N,N-dimethyl)aminoisophthalate
1301599-45-0

dimethyl 5-(N,N-dimethyl)aminoisophthalate

Conditions
Conditions Yield
In tetrahydrofuran; at 20 ℃; for 0.5h;
97%
L-glutamic dimethyl ester hydrochloride
23150-65-4

L-glutamic dimethyl ester hydrochloride

1,3-dimethyl 5-(bromomethyl)benzene-1,3-dicarboxylate
42268-88-2

1,3-dimethyl 5-(bromomethyl)benzene-1,3-dicarboxylate

(S)-5-((2-carboxy-5-oxopyrrolidin-1-yl)methyl)isophthalic acid

(S)-5-((2-carboxy-5-oxopyrrolidin-1-yl)methyl)isophthalic acid

Conditions
Conditions Yield
L-glutamic dimethyl ester hydrochloride; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
1,3-dimethyl 5-(bromomethyl)benzene-1,3-dicarboxylate; In N,N-dimethyl-formamide; at 55 ℃; for 48h;
43%

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